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Medications for Pulmonary Hypertension

Other names: PAH; Pulmonary Arterial Hypertension

What is Pulmonary Hypertension:  Pulmonary hypertension is usually caused by a narrowing of the small arteries of the lung, which makes it hard for blood to flow. Blood pressure increases. The right side of the heart must work harder to pump blood, and may become enlarged over time. Eventually, heart failure may develop.

Medications to treat Pulmonary Hypertension

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Revatio B N X 8 reviews
6.0

Generic name: sildenafil systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
sildenafil B N X 8 reviews
6.0

Generic name: sildenafil systemic

Brand name:  Revatio

Drug class: impotence agents, agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Letairis X N 9 reviews
8.0

Generic name: ambrisentan systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Adcirca B N X 5 reviews
5.0

Generic name: tadalafil systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Tracleer X N 3 reviews
7.0

Generic name: bosentan systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Remodulin B N 1 review
4.0

Generic name: treprostinil systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
isosorbide dinitrate Off Label C N Add review Rate

Generic name: isosorbide dinitrate systemic

Brand names:  Isordil, Isordil Titradose, Dilatrate-SR, IsoDitrate, Isochron

Drug class: antianginal agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

Off Label: Yes

 
Tyvaso B N 9 reviews
8.0

Generic name: treprostinil systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Flolan B N 2 reviews
8.0

Generic name: epoprostenol systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Isordil Off Label C N Add review Rate

Generic name: isosorbide dinitrate systemic

Drug class: antianginal agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
Ventavis C N Add review
8.0

Generic name: iloprost systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
ambrisentan X N 10 reviews
8.0

Generic name: ambrisentan systemic

Brand name:  Letairis

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
bosentan X N 3 reviews
7.0

Generic name: bosentan systemic

Brand name:  Tracleer

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
tadalafil B N X 5 reviews
6.0

Generic name: tadalafil systemic

Brand name:  Adcirca

Drug class: impotence agents, agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
Veletri B N Add review Rate

Generic name: epoprostenol systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Opsumit X N 2 reviews
10

Generic name: macitentan systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Adempas X N Add review Rate

Generic name: riociguat systemic

Drug class: vasodilators

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph

 
Orenitram B N Add review Rate

Generic name: treprostinil systemic

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
treprostinil B N 10 reviews
7.0

Generic name: treprostinil systemic

Brand names:  Remodulin, Tyvaso, Orenitram

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
epoprostenol B N 2 reviews
8.0

Generic name: epoprostenol systemic

Brand names:  Flolan, Veletri

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Isordil Titradose Off Label C N Add review Rate

Generic name: isosorbide dinitrate systemic

Drug class: antianginal agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
macitentan X N 2 reviews
10

Generic name: macitentan systemic

Brand name:  Opsumit

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
Dilatrate-SR Off Label C N Add review Rate

Generic name: isosorbide dinitrate systemic

Drug class: antianginal agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
IsoDitrate Off Label C N Add review Rate

Generic name: isosorbide dinitrate systemic

Drug class: antianginal agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
Uptravi N 5 reviews
4.0

Generic name: selexipag systemic

Drug class: agents for pulmonary hypertension

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
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Topics under Pulmonary Hypertension

Learn more about Pulmonary Hypertension

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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