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Medications for Pulmonary Arterial Hypertension

Other names: PAH; Pulmonary Hypertension

Pulmonary hypertension is usually caused by a narrowing of the small arteries of the lung, which makes it hard for blood to flow. Blood pressure increases. The right side of the heart must work harder to pump blood, and may become enlarged over time. Eventually, heart failure may develop.

Drugs used to treat Pulmonary Arterial Hypertension

The following list of medications are in some way related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
sildenafil 6.8 13 reviews for sildenafil to treat Pulmonary Arterial Hypertension
Rx B N X
Generic name:
sildenafil systemic
Brand names:
Revatio, Liqrev
Drug class:
impotence agents, agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Revatio 6.6 9 reviews for Revatio to treat Pulmonary Arterial Hypertension
Rx B N X
Generic name:
sildenafil systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Letairis 8.9 11 reviews for Letairis to treat Pulmonary Arterial Hypertension
Rx X N
Generic name:
ambrisentan systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Adcirca 6.6 7 reviews for Adcirca to treat Pulmonary Arterial Hypertension
Rx B N X
Generic name:
tadalafil systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
tadalafil 7.0 11 reviews for tadalafil to treat Pulmonary Arterial Hypertension
Rx B N X
Generic name:
tadalafil systemic
Brand names:
Adcirca, Alyq, Tadliq
Drug class:
impotence agents, agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Opsumit 8.2 10 reviews for Opsumit to treat Pulmonary Arterial Hypertension
Rx X N
Generic name:
macitentan systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Tracleer 9.5 5 reviews for Tracleer to treat Pulmonary Arterial Hypertension
Rx X N
Generic name:
bosentan systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
ambrisentan 7.8 14 reviews for ambrisentan to treat Pulmonary Arterial Hypertension
Rx X N
Generic name:
ambrisentan systemic
Brand name:
Letairis
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Remodulin 5.6 6 reviews for Remodulin to treat Pulmonary Arterial Hypertension
Rx B N
Generic name:
treprostinil systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Adempas 5.3 4 reviews for Adempas to treat Pulmonary Arterial Hypertension
Rx X N
Generic name:
riociguat systemic
Drug class:
vasodilators
For consumers:
dosage, interactions, side effects
Tyvaso 7.2 16 reviews for Tyvaso to treat Pulmonary Arterial Hypertension
Rx B N
Generic name:
treprostinil systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
bosentan 8.6 6 reviews for bosentan to treat Pulmonary Arterial Hypertension
Rx X N
Generic name:
bosentan systemic
Brand name:
Tracleer
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Flolan 8.0 2 reviews for Flolan to treat Pulmonary Arterial Hypertension
Rx B N
Generic name:
epoprostenol systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
treprostinil 6.9 23 reviews for treprostinil to treat Pulmonary Arterial Hypertension
Rx B N
Generic name:
treprostinil systemic
Brand names:
Remodulin, Tyvaso, Orenitram, Tyvaso DPI
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
macitentan 7.5 11 reviews for macitentan to treat Pulmonary Arterial Hypertension
Rx X N
Generic name:
macitentan systemic
Brand name:
Opsumit
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Uptravi 5.4 25 reviews for Uptravi to treat Pulmonary Arterial Hypertension
Rx N
Generic name:
selexipag systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Ventavis Rate Add review
Rx C N
Generic name:
iloprost systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Orenitram 8.0 1 review for Orenitram to treat Pulmonary Arterial Hypertension
Rx B N
Generic name:
treprostinil systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Veletri 7.5 2 reviews for Veletri to treat Pulmonary Arterial Hypertension
Rx B N
Generic name:
epoprostenol systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Alyq Rate Add review
Rx B N X
Generic name:
tadalafil systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
epoprostenol 7.8 4 reviews for epoprostenol to treat Pulmonary Arterial Hypertension
Rx B N
Generic name:
epoprostenol systemic
Brand names:
Flolan, Veletri
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Liqrev Rate Add review
Rx B N X
Generic name:
sildenafil systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
riociguat 4.2 6 reviews for riociguat to treat Pulmonary Arterial Hypertension
Rx X N
Generic name:
riociguat systemic
Brand name:
Adempas
Drug class:
vasodilators
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
Tadliq Rate Add review
Rx B N X
Generic name:
tadalafil systemic
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
iloprost Rate Add review
Rx C N
Generic name:
iloprost systemic
Brand name:
Ventavis
Drug class:
agents for pulmonary hypertension
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph

Frequently asked questions

Learn more about Pulmonary Arterial Hypertension

Care guides

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.