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Tyvaso Inhalation

Generic name: treprostinil (inhalation) [ tre-PROS-ti-nil ]
Drug class: Agents for pulmonary hypertension

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 22, 2022.

What is Tyvaso inhalation?

Tyvaso dilates (widens) the arteries and decreases the amount of blood clotting platelets in your body. These effects lower blood pressure in the pulmonary artery that leads from the heart to the lungs.

Tyvaso inhalation is used to treat pulmonary arterial hypertension (PAH).

Tyvaso improves your ability to exercise and can help prevent your condition from getting worse.


Before using Tyvaso, tell your doctor if you have a breathing disorder such as asthma or COPD (chronic obstructive pulmonary disease), an infection in your lungs (including pneumonia), low blood pressure, liver or kidney disease, or a bleeding or blood clotting disorder.

Tyvaso inhalation should be used only with the inhalation system. The inhalation system comes with patient instructions for safe and effective use. Do not use the medication at home if you do not fully understand how to use the inhalation system and properly clean it daily. Ask your doctor or pharmacist if you have any questions.

Before taking this medicine

You should not use Tyvaso if you are allergic to treprostinil.

To make sure Tyvaso is safe for you, tell your doctor if you have:

Tell your doctor if you are pregnant or breastfeeding.

How should I use Tyvaso inhalation?

Take Tyvaso exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Do not swallow Tyvaso inhalation solution. The solution should be inhaled using only the Tyvaso inhalation system.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Tyvaso inhalation is usually given 4 times per day at evenly spaced intervals during waking hours. Each time you use the medicine, you will inhale 9 to 12 breaths of the medicine. Follow your doctor's instructions.

Do not mix other inhalation medicines with Tyvaso solution in the inhalation system.

Wash your hands before preparing your Tyvaso doses in the inhalation system.

Before your first dose of each day, twist off the top of one ampule and empty the contents into the medicine cup of the inhalation system. One ampule of inhalation solution contains enough treprostinil for all 4 of a day's doses.

At the end of the day after your last dose, empty and rinse out the medicine cup, even if there is still some medicine left in it.

The effects of Tyvaso inhalation will lessen over time between doses. Talk with your doctor if you need to time your dosing around any planned activities.

Do not use more than 12 breaths per treatment session, 4 times per day.

Use Tyvaso regularly to get the most benefit. You should not reduce your dose or stop using this medicine suddenly. Stopping suddenly may make your condition worse. Get your prescription refilled before you run out of medicine completely. Make sure you have a backup inhalation system available so as not to interrupt your treatment if one system stops working.

Call your doctor if your symptoms do not improve, or if they get worse while using Tyvaso inhalation.

Store Tyvaso ampules in their foil pouch at room temperature away from moisture, heat, and light. Once you have opened a foil pouch, the ampules in it should be used within 7 days.

Store the inhalation system upright and tightly capped with the plugs when not in use. Any treprostinil in the medicine cup must be used within 24 hours. Throw away any unused medicine at the end of the day after your last dose.

Dosing information

Usual Adult Dose for Pulmonary Hypertension:

-Initial dose: 3 breaths (18 mcg) per treatment session 4 times a day; if 3 breaths are not tolerated, reduce to 1 or 2 breaths and subsequently increase to 3 breaths as tolerated
-Maintenance dose: Increase by an additional 3 breaths at about 1 to 2 week intervals as tolerated until the target dose of 9 breaths (54 mcg) is reached per treatment session 4 times a day
-Maximum dose: 9 breaths (54 mcg) per treatment session 4 times a day

-Administer in 4 separate, equally spaced (about 4 hours apart) treatment sessions each day during waking hours.
-This drug should be continued at the highest tolerated dose.
-Use only with the Tyvaso Inhalation System.

What happens if I miss a dose?

Use the medicine as soon as you can. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, warmth or tingling, vomiting, diarrhea, or feeling light-headed.

What should I avoid while using Tyvaso inhalation?

Avoid getting this medicine in your eyes. If contact does occur, rinse with water.

Avoid getting this medicine on your skin. If Tyvaso gets on your skin, wash the area with soap and water.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Tyvaso side effects

Get emergency medical help if you have signs of an allergic reaction to Tyvaso: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • easy bruising or bleeding (nosebleeds, bleeding gums), or any bleeding that will not stop;

  • unexpected vaginal bleeding;

  • coughing up blood or vomit that looks like coffee grounds; or

  • blood in your urine or stools, black or tarry stools.

Common Tyvaso side effects may include:

  • cough, sore throat;

  • muscle, jaw or bone pain;

  • pain or irritation in your throat after use;

  • dizziness or feeling light-headed;

  • nausea, diarrhea;

  • headache; or

  • flushing (warmth, redness or tingling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Tyvaso?

Other drugs may interact with treprostinil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Tyvaso only for the indication prescribed.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.