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Generic name: riociguatRYE-oh-SIG-ue-at ]
Drug class: Vasodilators

Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 22, 2024.

What is Adempas?

Adempas lowers blood pressure in your lungs, helping your heart pump blood more efficiently.

Adempas is used to treat chronic thromboembolic pulmonary hypertension (CTEPH) in people who cannot be treated with surgery, or in people who have undergone surgery but still have symptoms. Riociguat can treat certain symptoms of CTEPH and can improve your ability to exercise.

Adempas is also used to treat pulmonary arterial hypertension (PAH). Riociguat can improve your ability to exercise and help prevent PAH from getting worse.

Adempas is available to women only under a special program. You must be registered in the program and understand the risks and benefits of this medicine.


Adempas can cause birth defects. Do not use if you are pregnant. You must use highly effective birth control while taking Adempas and for at least 1 month after your last dose. Do not have unprotected sex.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with riociguat, and some drugs should not be used together.

Before taking this medicine

You should not use Adempas if you are allergic to riociguat, or if:

Some medicines can cause unwanted or dangerous effects when used with Adempas. Your doctor may change your treatment plan if you also use:

Do not take Adempas within 24 hours before or after taking sildenafil (Revatio, Viagra), or within 24 hours before or 48 hours after taking tadalafil (Adcirca, Cialis).

To make sure Adempas is safe for you, tell your doctor if you have ever had:

Do not use Adempas if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 month after your treatment ends. Tell your doctor right away if you miss a menstrual period or think you may have become pregnant during treatment.

You will need to have a negative pregnancy test before starting this treatment. You will also be re-tested every month during your treatment, and 1 month after you stop taking this medicine. Do not have unprotected sex.

While taking Adempas, girls and women who are able to get pregnant must use highly effective birth control, or two methods together.

Even if you are not planning a pregnancy, you are considered able to become pregnant if:

Adempas comes with patient instructions about acceptable forms of birth control to use while taking this medicine. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Even if your sexual partner has had a vasectomy, you must still use a second method of birth control--either a barrier method or a hormonal form (birth control pills, injections, skin patch, or vaginal ring).

If you are the parent or caregiver of a female child taking this medication, talk to the child's doctor once you notice any signs of puberty (breast development or pubic hair), even if menstrual periods have not yet begun.

You should not breast-feed while using this medicine.

How should I take Adempas?

Take Adempas exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take Adempas with or without food.

If you cannot swallow a tablet whole, you may crush the tablet and mix it with water or soft food (such as applesauce). Swallow the mixture right away without chewing. Do not save it for later use.

Your blood pressure will need to be checked often.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Pulmonary Hypertension:

Initial dose: 1 mg orally 3 times a day
Maximum dose: 2.5 mg orally 3 times a day

-For patients who cannot tolerate the hypotensive effect, consider a starting dose of 0.5 mg orally 3 times a day. If systolic blood pressure remains greater than 95 mmHg and the patient has no signs of hypotension, the dose may be titrated up by 0.5 mg orally 3 times a day.
-Dose increases should be no more frequent than every 2 weeks.

-Persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) (WHO group 4) after surgical treatment or inoperable CTEPH to improve exercise capacity and WHO functional class.
-As monotherapy or in combination with endothelin receptor antagonists or prostanoids to treat pulmonary arterial hypertension (PAH) (WHO group 1) to improve exercise capacity, improve WHO functional class and to delay clinical worsening.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

Call your doctor if you miss your doses for 3 days in a row or longer.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What to avoid

Do not have unprotected sex while taking Adempas. You must use birth control to prevent pregnancy during treatment and for at least 30 days after you stop taking this medicine.

Avoid taking an antacid within 1 hour before or 1 hour after you take Adempas. Some antacids can make it harder for your body to absorb riociguat.

Smoking can make riociguat less effective. Tell your doctor if you start or stop smoking while you are taking this medicine. Your dose needs may need to be changed.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Adempas side effects

Get emergency medical help if you have signs of an allergic reaction to Adempas: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Adempas and call your doctor at once if you have:

Common Adempas side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Adempas?

Other drugs may interact with riociguat, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Adempas only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.