Skip to Content

Adempas Side Effects

Generic Name: riociguat

Note: This page contains information about the side effects of riociguat. Some of the dosage forms included on this document may not apply to the brand name Adempas.

In Summary

Common side effects of Adempas include: dyspepsia, gastritis, and headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to riociguat: oral tablet

In addition to its needed effects, some unwanted effects may be caused by riociguat (the active ingredient contained in Adempas). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking riociguat:

More common:
  • Confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nosebleeds
  • unusual tiredness or weakness
Less common:
  • Abdominal or stomach pain or swelling
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or black, tarry stools
  • bruising or purple areas on the skin
  • coughing or spitting up blood
  • decreased alertness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • heavy non-menstrual vaginal bleeding
  • rapid weight gain
  • troubled breathing with exertion
  • vomiting of blood or material that looks like coffee grounds

Minor Side Effects

Some of the side effects that can occur with riociguat may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Diarrhea
  • headache
  • heartburn or indigestion
  • nausea or vomiting
  • stuffy nose
Less common:
  • Difficulty having a bowel movement (stool)

For Healthcare Professionals

Applies to riociguat: oral tablet

Cardiovascular

Very common (10% or more): Hypotension (10%)
Frequency not reported: Palpitations, peripheral edema[Ref]

Gastrointestinal

Very common (10% or more): Dyspepsia (21%), gastritis (21%), nausea (14%), diarrhea (12%), vomiting (10%)
Common (1% to 10%): Gastroesophageal reflux disease, constipation
Frequency not reported: Dysphagia, abdominal distention[Ref]

Hematologic

Common (1% to 10%): Anemia[Ref]

Nervous system

Very common (10% or more): Headache (27%), dizziness (20%)[Ref]

Respiratory

Frequency not reported: Nasal congestion, epistaxis[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Adempas (riociguat)." Bayer Pharmaceutical Inc, West Haven, CT.

Not all side effects for Adempas may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide