Adempas Side Effects
Generic Name: riociguat
Note: This document contains side effect information about riociguat. Some of the dosage forms listed on this page may not apply to the brand name Adempas.
Common side effects of Adempas include: dyspepsia, gastritis, and headache. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to riociguat: oral tablet
Oral route (Tablet)
Do not administer riociguat to a pregnant female because it may cause fetal harm. Females of reproductive potential: Exclude pregnancy before start of treatment, monthly during treatment, and 1 month after treatment discontinuation. To prevent pregnancy, females of reproductive potential must use effective forms of contraception during treatment and for one month after stopping treatment. For all females, riociguat is available only through a restricted program called the Adempas REMS Program.
Side effects requiring immediate medical attention
Along with its needed effects, riociguat (the active ingredient contained in Adempas) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking riociguat:
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- unusual tiredness or weakness
- Bloating or swelling of the face, arms, hands, lower legs, or feet
- bloody or black, tarry stools
- bruising or purple areas on the skin
- coughing or spitting up blood
- decreased alertness
- fast, irregular, pounding, or racing heartbeat or pulse
- heavy non-menstrual vaginal bleeding
- rapid weight gain
- stomach pain or swelling
- troubled breathing with exertion
- vomiting of blood or material that looks like coffee grounds
Side effects not requiring immediate medical attention
Some side effects of riociguat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Difficulty having a bowel movement
For Healthcare Professionals
Applies to riociguat: oral tablet
Very common (10% or more): Peripheral edema (up to 17.3%), hypotension (up to 10%)
Common (1% to 10%): Palpitation, chest pain, chest discomfort[Ref]
Very common (10% or more): Headache (up to 27%), dizziness (up to 20%)[Ref]
Very common (10% or more): Dyspepsia (up to 21%), gastritis (21%), nausea (up to 14.1%), diarrhea (up to 12%), vomiting (up to 10.2%)
Very common (10% or more): Hemoglobin decreased (24.1%), hematocrit decreased (13.3%)
Common (1% to 10%): Anemia[Ref]
Very common (10% or more): Nasopharyngitis (11.8%)
Frequency not reported: Pulmonary hemorrhage[Ref]
Common (1% to 10%): Pain in extremity[Ref]
Common (1% to 10%): Fatigue[Ref]
1. Cerner Multum, Inc. "Australian Product Information." O 0
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. "Product Information. Adempas (riociguat)." Bayer Pharmaceutical Inc, West Haven, CT.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
More about Adempas (riociguat)
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 2 Reviews
- Drug class: vasodilators
- FDA Approval History