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Generic Name: tadalafil (ta DAL a fil)
Brand Names: Adcirca, Cialis

What is Adcirca?

Adcirca (tadalafil) relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.

Adcirca is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.

Another brand of tadalafil is Cialis which used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate) in men. Do not take Adcirca while also taking Cialis, unless your doctor tells you to.

Important information

Do not take Adcirca if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as "poppers". Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

Some medicines can cause unwanted or dangerous effects when used with Adcirca. Tell your doctor about all your current medicines, especially riociguat (Adempas).

Get medical help at once if you have nausea, chest pain, or dizziness during sex.

Stop using Adcirca and get emergency medical help if you have sudden vision loss.

Before taking this medicine

You should not take Adcirca if you are allergic to tadalafil.

Taking Adcirca with certain other medicines can cause a sudden and serious decrease in blood pressure. Do not take this medicine if you also use:

  • riociguat (to treat pulmonary arterial hypertension); or

  • a nitrate drug (for chest pain or heart problems) such as nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, or recreational drugs such as amyl nitrate or nitrite "poppers".

Some Adcirca can remain in your bloodstream for 2 or more days after each dose you take (longer if you have liver or kidney disease). Avoid nitrate use during this time.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • heart disease or heart rhythm problems;

  • a heart attack or stroke;

  • angina (chest pain), high or low blood pressure;

  • pulmonary hypertension (unless you are taking tadalafil for this);

  • a condition called pulmonary veno-occlusive disease (narrowing of the veins that carry blood from the lungs to the heart);

  • liver or kidney disease (or if you are on dialysis);

  • vision loss, or retinitis pigmentosa (an inherited condition of the eye);

  • a bleeding disorder;

  • a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;

  • a physical deformity of the penis (such as Peyronie's disease), or an erection lasting longer than 4 hours;

  • a stomach ulcer; or

  • health problems that make sexual activity unsafe.

Sudden vision loss has occurred in a small number of people taking medicines like tadalafil (Viagra or others). Most of these people already had certain eye problems or risk factors for blood vessel disorders (heart disease, diabetes, high blood pressure, high cholesterol, coronary artery disease, smoking, or being over 50 years old). It is not clear whether the medicine was the actual cause of vision loss.

Adcirca is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether tadalafil passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Adcirca is not approved for use by anyone younger than 18 years old.

How should I take Adcirca?

Adcirca is usually taken only once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Adcirca can be taken with or without food.

Do not take Cialis for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension.

Store at room temperature away from moisture and heat.

Adcirca dosing information

Usual Adult Dose for Pulmonary Hypertension:

- 40 mg orally once a day

Comment: Dividing the 40 mg dose over the course of the day is not recommended.

See also: Dosage Information (in more detail)

What happens if I miss a dose?

If you miss a dose, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Adcirca?

Drinking alcohol with this medicine can cause side effects.

Grapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine.

Adcirca side effects

Get emergency medical help if you have signs of an allergic reaction to Adcirca: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop and get medical help at once if you have nausea, chest pain, or dizziness during sex. You could be having a life-threatening side effect.

Stop using Adcirca and call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • an erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis);

  • vision changes or sudden vision loss;

  • ringing in your ears or sudden hearing loss; or

  • heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Common Adcirca side effects may include:

  • headache;

  • flushing (warmth, redness, or tingly feeling);

  • nausea, upset stomach;

  • stuffy nose; or

  • muscle pain, back pain, pain in your arms or legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Adcirca?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • medicines to treat erectile dysfunction or pulmonary arterial hypertension;

  • an antibiotic or antifungal medicine;

  • antiviral medicine to treat hepatitis C or HIV/AIDS;

  • drugs to treat high blood pressure or a prostate disorder; or

  • seizure medicine.

This list is not complete. Other drugs may interact with tadalafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Adcirca.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Adcirca only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Cerner Multum, Inc. Version: 11.01.

Date modified: July 10, 2017
Last reviewed: May 18, 2017

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