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Selexipag Dosage

Medically reviewed on January 10, 2018.

Applies to the following strengths: 200 mcg; 400 mcg; 600 mcg; 800 mcg; 1000 mcg; 1200 mcg; 1400 mcg; 1600 mcg; 200 mcg-800 mcg

Usual Adult Dose for Pulmonary Hypertension

Initial dose: 200 mcg orally twice a day
Maintenance dose: Increase in increments of 200 mcg orally twice a day at weekly intervals to the highest tolerated dose
Maximum dose: 1600 mcg orally twice a day

Comment:
-If the patient reaches a dose that is not well tolerated, reduce to a previously tolerated dose.

Use: For the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce the risk of hospitalization for PAH

Renal Dose Adjustments

Estimated GFR (eGFR) greater than 15 mL/min/1.73 m2: No adjustment recommended.
eGFR less than 15 mL/min/ 1.73 m2: Data not available

Liver Dose Adjustments

Mild liver dysfunction (Child-Pugh A): No adjustment recommended.
Moderate liver dysfunction (Child-Pugh B): 200 mcg orally once a day; increase in increments of 200 mcg orally once a day at weekly intervals as tolerated.
Severe liver dysfunction (Child-Pugh C): Not recommended.

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Do not split, crush, or chew.
-Tolerability may be improved when taken with food.
-If a dose is missed, take the next dose as soon as possible unless the next dose is within the next 6 hours.
-If treatment is missed for 3 days or more, restart at lower dose and then retitrate.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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