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Selexipag Dosage

Medically reviewed by Last updated on Oct 8, 2021.

Applies to the following strengths: 200 mcg; 400 mcg; 600 mcg; 800 mcg; 1000 mcg; 1200 mcg; 1400 mcg; 1600 mcg; 200 mcg-800 mcg; 1800 mcg

Usual Adult Dose for Pulmonary Hypertension

Initial dose: 200 mcg orally twice a day
Maintenance dose: Increase in increments of 200 mcg orally twice a day at weekly intervals to the highest tolerated dose
Maximum dose: 1600 mcg orally twice a day


  • If the patient reaches a dose that is not well tolerated, reduce to a previously tolerated dose.

Use: For the treatment of pulmonary arterial hypertension (PAH) to delay disease progression and reduce the risk of hospitalization for PAH

Renal Dose Adjustments

Estimated GFR (eGFR) greater than 15 mL/min/1.73 m2: No adjustment recommended.
eGFR less than 15 mL/min/ 1.73 m2: Data not available

Liver Dose Adjustments

Mild liver dysfunction (Child-Pugh A): No adjustment recommended.
Moderate liver dysfunction (Child-Pugh B): 200 mcg orally once a day; increase in increments of 200 mcg orally once a day at weekly intervals as tolerated.
Severe liver dysfunction (Child-Pugh C): Not recommended.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

  • Do not split, crush, or chew.
  • Tolerability may be improved when taken with food.
  • If a dose is missed, take the next dose as soon as possible unless the next dose is within the next 6 hours.
  • If treatment is missed for 3 days or more, restart at lower dose and then retitrate.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.