Skip to main content

Selexipag Side Effects

Medically reviewed by Last updated on Jul 4, 2021.

In Summary

Commonly reported side effects of selexipag include: diarrhea, headache, jaw pain, limb pain, myalgia, nausea, vomiting, and flushing. Other side effects include: anemia, and decreased appetite. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to selexipag: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, selexipag may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking selexipag:

Incidence not known

  • Blue lips and fingernails
  • chest pain
  • coughing that sometimes produces a pink frothy sputum
  • difficult, fast, noisy breathing
  • increased sweating
  • pale skin
  • swelling in the legs and ankles

Side effects not requiring immediate medical attention

Some side effects of selexipag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Decreased appetite
  • diarrhea
  • feeling of warmth
  • headache
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • nausea
  • pain in the jaw, arms, or legs
  • rash
  • redness of the face, neck, arms, and occasionally, upper chest
  • swollen joints
  • vomiting

For Healthcare Professionals

Applies to selexipag: intravenous injection, oral tablet


Very common (10% or more): Flushing (up to 12%), sinus tachycardia (up to 11.3%)

Common (1% to 10%): Hypotension

Frequency not reported: Hot flush

Postmarketing reports: Symptomatic hypotension[Ref]


Very common (10% or more): Diarrhea (up to 42%), nausea (up to 34%), vomiting (up to 18%)

Common (1% to 10%): Abdominal pain, dyspepsia, abdominal discomfort

Frequency not reported: Ascites[Ref]


The most frequently reported side effects included headache, diarrhea, jaw pain, nausea, myalgia, vomiting, pain in extremity, and flushing.[Ref]


Very common (10% or more): Rash (11%)

Common (1% to 10%): Urticaria, erythema[Ref]


Common (1% to 10%): Hyperthyroidism, thyroid stimulating hormone decreased[Ref]


Common (1% to 10%): Anemia, hemoglobin decreased[Ref]


Frequency not reported (injection): Infusion-site reactions (erythema, redness, pain, swelling)


Common (1% to 10%): Appetite decreased[Ref]


Very common (10% or more): Jaw pain (26%), pain in extremity (up to 17%), myalgia (up to 16%), arthralgia (up to 11%)

Common (1% to 10%): Musculoskeletal pain, neck pain

Frequency not reported: Bone pain[Ref]

Nervous system

Very common (10% or more): Headache (up to 65%)

Frequency not reported: Burning sensation[Ref]


Common (1% to 10%): Eye pain, retinal disorder[Ref]


Common (1% to 10%): Malignancy[Ref]


Common (1% to 10%): Asthenia, pyrexia, pain, influenza, weight decreased[Ref]


Frequency not reported: Acute renal failure


Very common (10% or more): Nasopharyngitis (13%)

Common (1% to 10%): Nasal congestion

Frequency not reported: Pulmonary veno-occlusive disease[Ref]

Frequently asked questions


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Uptravi (selexipag)." Actelion Pharmaceuticals US Inc, South San Francisco, CA.

3. Cerner Multum, Inc. "Australian Product Information." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.