Skip to Content

Selexipag Side Effects

For the Consumer

Applies to selexipag: oral tablet

Along with its needed effects, selexipag may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking selexipag:

Incidence not known
  • Blue lips and fingernails
  • chest pain
  • coughing that sometimes produces a pink frothy sputum
  • difficult, fast, noisy breathing, sometimes with wheezing
  • increased sweating
  • pale skin
  • swelling in the legs and ankles

Some side effects of selexipag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Decreased appetite
  • diarrhea
  • feeling of warmth
  • headache
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • nausea
  • pain in the jaw, arms, or legs
  • rash
  • redness of the face, neck, arms, and occasionally, upper chest
  • swollen joints
  • vomiting

For Healthcare Professionals

Applies to selexipag: oral tablet

General

The most frequently reported side effects included headache, diarrhea, jaw pain, nausea, myalgia, vomiting, pain in extremity, and flushing.[Ref]

Nervous system

Very common (10% or more): Headache (up to 65%)
Frequency not reported: Burning sensation[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 42%), nausea (up to 34%), vomiting (up to 18%)
Common (1% to 10%): Abdominal pain, dyspepsia, abdominal discomfort
Frequency not reported: Ascites[Ref]

Musculoskeletal

Very common (10% or more): Jaw pain (26%), pain in extremity (up to 17%), myalgia (up to 16%), arthralgia (up to 11%)
Common (1% to 10%): Musculoskeletal pain, neck pain
Frequency not reported: Bone pain[Ref]

Cardiovascular

Very common (10% or more): Flushing (up to 12%), sinus tachycardia (up to 11.3%)
Common (1% to 10%): Hypotension
Frequency not reported: Hot flush[Ref]

Dermatologic

Very common (10% or more): Rash (11%)
Common (1% to 10%): Urticaria, erythema[Ref]

Respiratory

Very common (10% or more): Nasopharyngitis (13%)
Common (1% to 10%): Nasal congestion
Frequency not reported: Pulmonary veno-occlusive disease[Ref]

Endocrine

Common (1% to 10%): Hyperthyroidism, thyroid stimulating hormone decreased[Ref]

Hematologic

Common (1% to 10%): Anemia, hemoglobin decreased[Ref]

Metabolic

Common (1% to 10%): Appetite decreased[Ref]

Ocular

Common (1% to 10%): Eye pain, retinal disorder[Ref]

Oncologic

Common (1% to 10%): Malignancy[Ref]

Other

Common (1% to 10%): Asthenia, pyrexia, pain, influenza, weight decreased[Ref]

Renal

Frequency not reported: Acute renal failure

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Uptravi (selexipag)." Actelion Pharmaceuticals US Inc, South San Francisco, CA.

Some side effects of selexipag may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide