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Ambrisentan Dosage

Medically reviewed by Drugs.com. Last updated on Aug 20, 2024.

Applies to the following strengths: 5 mg; 10 mg

Usual Adult Dose for Pulmonary Hypertension

Initial dose: 5 mg orally once a day.

Comments:


Uses:

Renal Dose Adjustments

Liver Dose Adjustments


If hepatic impairment develops after starting on the drug, the cause should be fully investigated and the drug should be discontinued if:

Dose Adjustments

When coadministered with cyclosporine, the dose of ambrisentan should be limited to 5 mg once a day.

Precautions

The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for ambrisentan. It includes elements to assure safe use and an implementation system. For additional information: http://www.accessdata.fda.gov/scripts/cder/rems/index.cfm

US BOXED WARNING:
Embryo-Fetal Toxicity:

Recommendations:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration Advice:


General:

Monitoring Considerations:

Patient Advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.