Revatio Dosage

Generic name: SILDENAFIL CITRATE 20mg
Dosage forms: tablet, film coated, injection, oral powder
Drug class: Agents for pulmonary hypertension

Medically reviewed by Drugs.com. Last updated on Oct 3, 2024.

Recommended Dosage in Adults

Oral Dosage

The recommended dosage of REVATIO is 20 mg three times a day. Dose may be titrated to a maximum of 80 mg three times a day, if required, based on symptoms and tolerability.

Although dose-response improvement in exercise ability was not observed in short-term studies in adults with PAH, the delay in clinical worsening with long-term use of sildenafil in Study A1481324 supports dosing up to a maximum of 80 mg three times a day.

Intravenous Dosage

The recommended dose is 10 mg administered as an intravenous bolus injection three times a day. The dose of REVATIO injection does not need to be adjusted for body weight.

A 10-mg dose of REVATIO injection is predicted to provide pharmacological effect of sildenafil and its N-desmethyl metabolite equivalent to that of a 20-mg oral dose.

Recommended Dosage in Pediatric Patients

Oral Dosage

The recommended dosage in patients ≤ 20 kg is 10 mg three times a day.

For pediatric patients 20 kg to 45 kg, the recommended dosage is 20 mg three times a day.

For pediatric patients 45 kg and greater, the recommended dosage is 20 mg three times a day. A maximum dose in pediatric patients has not been identified. Based on the experience in adults, dose may be titrated to a maximum of 40 mg three times a day for pediatric patients > 45 kg, if required, based on symptoms and tolerability.

Reconstitution of the Powder for Oral Suspension

Note: Reconstitute the contents of the bottle with a total volume of 90 mL (60 mL followed by 30 mL). Refer to the detailed instructions below.

1.: Tap the bottle to loosen the powder.
2.: Add 60 mL of water to the bottle.
3.: Replace the cap and shake the bottle vigorously for a minimum of 30 seconds.
4.: Add another 30 mL of water to the bottle.
5.: Replace the cap and shake the bottle vigorously for a minimum of 30 seconds.
6.: Remove cap and press the bottle adaptor into the neck of the bottle. Replace the cap on the bottle.
7.: Write the expiration date of the reconstituted oral suspension on the bottle label (the expiration date of the reconstituted oral suspension is 60 days from the date of reconstitution).