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Treprostinil Dosage

Medically reviewed by Drugs.com. Last updated on Jul 10, 2023.

Applies to the following strengths: 1 mg/mL; 2.5 mg/mL; 5 mg/mL; 10 mg/mL; 0.6 mg/mL; 0.125 mg; 0.25 mg; 1 mg; 2.5 mg; 5 mg; 0.125 mg-0.25 mg; 0.125 mg-0.25 mg-1 mg; 16 mcg-32 mcg; 16 mcg-32 mcg-48 mcg; 16 mcg; 32 mcg-48 mcg; 32 mcg; 48 mcg; 64 mcg

Usual Adult Dose for Pulmonary Hypertension

ORAL:
Extended-release tablets:


Comments:

Inhalation:

Comments:

PARENTERAL:
Patients New to Prostacyclin Infusion Therapy:

Comments:

Patients Transitioning from Epoprostenol:

Comments: Transition from epoprostenol to treprostinil is accomplished by initiating the infusion of treprostinil and increasing it, while simultaneously reducing the dose of IV epoprostenol and should take place in a hospital setting.

Use: For the treatment of PAH (WHO Group 1) to improve exercise capacity

Renal Dose Adjustments

No adjustment recommended, however, doses should be titrated slowly in patients with renal insufficiency.

Liver Dose Adjustments

Extended-release tablets:


Oral inhalation: Titrate dose slowly in patients with liver dysfunction

Parenteral:

Dose Adjustments

Conversion from parenteral treprostinil to oral extended-release tablets:


Oral (extended-release tablets) total daily dose (mg) = 0.0072 x Parenteral treprostinil dose (ng/kg/min) x weight (kg)

Coadministration with strong CYP450 2C8 inhibitors (e.g., gemfibrozil):
Extended-release tablets:

Interruptions and discontinuation:

Parenteral treprostinil (ng/kg/min) = 139 x Oral extended-release tablet total daily dose (mg) divided by weight (kg)

Precautions

Oral Inhalation and Extended-release Tablets: Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Extended-release tablets: No adjustment recommended.

Parenteral and oral inhalation: Data not available

Other Comments

Administration Advice:


ER Tablets:

Parenteral:

Inhalation:

Storage requirements:

Reconstitution/preparation techniques:

IV compatibility: The manufacturer product information should be consulted.

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.