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Treprostinil (inhalation)

Generic name: treprostinil (inhalation) (tre PROS ti nil)
Brand name: Tyvaso
Dosage forms: inhalation solution (0.6 mg/mL)
Drug class: Agents for pulmonary hypertension

Medically reviewed by Drugs.com on Apr 12, 2021. Written by Cerner Multum.

What is treprostinil inhalation?

Treprostinil is used to treat pulmonary arterial hypertension (PAH). treprostinil improves your ability to exercise and can help prevent your condition from getting worse.

Treprostinil may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use treprostinil if you are allergic to it.

Tell your doctor if you have ever had:

Tell your doctor if you are pregnant or breastfeeding.

How should I use treprostinil inhalation?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Do not swallow treprostinil inhalation. The medicine should be inhaled using only the Tyvaso inhalation system.

Treprostinil inhalation should be used only with a Tyvaso inhalation system. Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Treprostinil inhalation is usually given 4 times per day at evenly spaced intervals during waking hours. Each time you use the medicine, you will inhale 9 to 12 breaths of the medicine. Follow your doctor's instructions.

Do not mix other inhalation medicines with treprostinil in the Tyvaso inhalation system.

Wash your hands before preparing your treprostinil doses in the inhalation system.

Before your first dose of each day, twist off the top of one ampule and empty the contents into the medicine cup of the inhalation system. One ampule of treprostinil inhalation contains enough medicine for all 4 of a day's doses.

At the end of the day after your last dose, empty and rinse out the medicine cup, even if there is still some medicine left in it.

The effects of treprostinil inhalation will lessen over time between doses. Talk with your doctor if you need to time your dosing around any planned activities.

Do not use more than 12 breaths per treatment session, 4 times per day.

Use treprostinil regularly to get the most benefit. You should not reduce your dose or stop using treprostinil suddenly. Stopping suddenly may make your condition worse. Get your prescription refilled before you run out of medicine completely. Make sure you have a backup inhalation system available so as not to interrupt your treatment if one system stops working.

Call your doctor if your symptoms do not improve, or if they get worse while using treprostinil inhalation.

Store treprostinil ampules in their foil pouch at room temperature away from moisture, heat, and light. Once you have opened a foil pouch, the ampules in it should be used within 7 days.

Store the inhalation system upright and tightly capped with the plugs when not in use. Any treprostinil in the medicine cup must be used within 24 hours. Throw away any unused medicine at the end of the day after your last dose.

What happens if I miss a dose?

Use the medicine as soon as you can. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include headache, warmth or tingling, vomiting, diarrhea, or feeling light-headed.

What should I avoid while using treprostinil inhalation?

Rinse with water if this medication gets in your eyes.

If this medication gets on your skin, wash the area with soap and water.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Treprostinil inhalation side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • easy bruising or bleeding (nosebleeds, bleeding gums), or any bleeding that will not stop;

  • unexpected vaginal bleeding;

  • coughing up blood or vomit that looks like coffee grounds; or

  • blood in your urine or stools, black or tarry stools.

Common side effects may include:

  • cough, sore throat;

  • pain or irritation in your throat after use;

  • dizziness or feeling light-headed;

  • nausea, diarrhea;

  • headache; or

  • flushing (warmth, redness or tingling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect treprostinil inhalation?

Other drugs may affect treprostinil, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Does Treprostinil interact with my other drugs?

Enter other medications to view a detailed report.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.