Uptravi Side Effects

Generic name: selexipag

Medically reviewed by Drugs.com. Last updated on Feb 11, 2025.

Note: This document provides detailed information about Uptravi Side Effects associated with selexipag. Some dosage forms listed on this page may not apply specifically to the brand name Uptravi.

Applies to selexipag: oral tablet.

Other dosage forms:

• intravenous powder for solution

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Do not use this medicine together with gemfibrozil (Lopid®). Using these medicines together may increase your chance for more serious side effects.

Check with your doctor right away if you have blue lips and fingernails, chest pain, coughing that sometimes produces a pink frothy sputum, difficult, fast, or noisy breathing, sometimes with wheezing, pale skin, increased sweating, or swelling in the legs and ankles. These may be symptoms of pulmonary edema (fluid in the lungs).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of Uptravi

Some side effects of selexipag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Uptravi

Along with its needed effects, selexipag (the active ingredient contained in Uptravi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking selexipag:

For healthcare professionals

Applies to selexipag: intravenous injection, oral tablet.

General adverse events

The most frequently reported side effects included headache, diarrhea, jaw pain, nausea, myalgia, vomiting, pain in extremity, and flushing.^[Ref]

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 42%), nausea (up to 34%), vomiting (up to 18%)
• Common (1% to 10%): Abdominal pain, dyspepsia, abdominal discomfort
• Frequency not reported: Ascites^[Ref]

Cardiovascular

• Very common (10% or more): Flushing (up to 12%), sinus tachycardia (up to 11.3%)
• Common (1% to 10%): Hypotension
• Frequency not reported: Hot flush
• Postmarketing reports: Symptomatic hypotension^[Ref]

Dermatologic

• Very common (10% or more): Rash (11%)
• Common (1% to 10%): Urticaria, erythema^[Ref]

Endocrine

• Common (1% to 10%): Hyperthyroidism, thyroid stimulating hormone decreased^[Ref]

Hematologic

• Common (1% to 10%): Anemia, hemoglobin decreased^[Ref]

Local

• Frequency not reported (injection): Infusion-site reactions (erythema, redness, pain, swelling)

Metabolic

• Common (1% to 10%): Appetite decreased^[Ref]

Musculoskeletal

• Very common (10% or more): Jaw pain (26%), pain in extremity (up to 17%), myalgia (up to 16%), arthralgia (up to 11%)
• Common (1% to 10%): Musculoskeletal pain, neck pain
• Frequency not reported: Bone pain^[Ref]

Nervous system

• Very common (10% or more): Headache (up to 65%)
• Frequency not reported: Burning sensation^[Ref]

Ocular

• Common (1% to 10%): Eye pain, retinal disorder^[Ref]

Oncologic

• Common (1% to 10%): Malignancy^[Ref]

Other

• Common (1% to 10%): Asthenia, pyrexia, pain, influenza, weight decreased^[Ref]

Renal

• Frequency not reported: Acute renal failure

Respiratory

• Very common (10% or more): Nasopharyngitis (13%)
• Common (1% to 10%): Nasal congestion
• Frequency not reported: Pulmonary veno-occlusive disease^[Ref]

See also:

Frequently asked questions

• What is the drug Uptravi used for?

Further information

Uptravi side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer