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Uptravi Side Effects

Generic Name: selexipag

Note: This document contains side effect information about selexipag. Some of the dosage forms listed on this page may not apply to the brand name Uptravi.

In Summary

Common side effects of Uptravi include: diarrhea, headache, jaw pain, limb pain, myalgia, nausea, vomiting, and flushing. Other side effects include: anemia, and decreased appetite. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to selexipag: oral tablet

Along with its needed effects, selexipag (the active ingredient contained in Uptravi) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking selexipag:

Incidence not known
  • Blue lips and fingernails
  • chest pain
  • coughing that sometimes produces a pink frothy sputum
  • difficult, fast, noisy breathing
  • increased sweating
  • pale skin
  • swelling in the legs and ankles

Some side effects of selexipag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Decreased appetite
  • diarrhea
  • feeling of warmth
  • headache
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • nausea
  • pain in the jaw, arms, or legs
  • rash
  • redness of the face, neck, arms, and occasionally, upper chest
  • swollen joints
  • vomiting

For Healthcare Professionals

Applies to selexipag: oral tablet


The most frequently reported side effects included headache, diarrhea, jaw pain, nausea, myalgia, vomiting, pain in extremity, and flushing.[Ref]

Nervous system

Very common (10% or more): Headache (up to 65%)
Frequency not reported: Burning sensation[Ref]


Very common (10% or more): Diarrhea (up to 42%), nausea (up to 34%), vomiting (up to 18%)
Common (1% to 10%): Abdominal pain, dyspepsia, abdominal discomfort
Frequency not reported: Ascites[Ref]


Very common (10% or more): Jaw pain (26%), pain in extremity (up to 17%), myalgia (up to 16%), arthralgia (up to 11%)
Common (1% to 10%): Musculoskeletal pain, neck pain
Frequency not reported: Bone pain[Ref]


Very common (10% or more): Flushing (up to 12%), sinus tachycardia (up to 11.3%)
Common (1% to 10%): Hypotension
Frequency not reported: Hot flush[Ref]


Very common (10% or more): Rash (11%)
Common (1% to 10%): Urticaria, erythema[Ref]


Very common (10% or more): Nasopharyngitis (13%)
Common (1% to 10%): Nasal congestion
Frequency not reported: Pulmonary veno-occlusive disease[Ref]


Common (1% to 10%): Hyperthyroidism, thyroid stimulating hormone decreased[Ref]


Common (1% to 10%): Anemia, hemoglobin decreased[Ref]


Common (1% to 10%): Appetite decreased[Ref]


Common (1% to 10%): Eye pain, retinal disorder[Ref]


Common (1% to 10%): Malignancy[Ref]


Common (1% to 10%): Asthenia, pyrexia, pain, influenza, weight decreased[Ref]


Frequency not reported: Acute renal failure


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Uptravi (selexipag)." Actelion Pharmaceuticals US Inc, South San Francisco, CA.

Some side effects of Uptravi may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.