Skip to Content

Riociguat Side Effects

In Summary

Commonly reported side effects of riociguat include: dyspepsia, gastritis, and headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to riociguat: oral tablet

As well as its needed effects, riociguat may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking riociguat, check with your doctor immediately:

More common:
  • Confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • nosebleeds
  • unusual tiredness or weakness
Less common:
  • Abdominal or stomach pain or swelling
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or black, tarry stools
  • bruising or purple areas on the skin
  • coughing or spitting up blood
  • decreased alertness
  • fast, irregular, pounding, or racing heartbeat or pulse
  • heavy non-menstrual vaginal bleeding
  • rapid weight gain
  • troubled breathing with exertion
  • vomiting of blood or material that looks like coffee grounds

Minor Side Effects

Some riociguat side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Diarrhea
  • headache
  • heartburn or indigestion
  • nausea or vomiting
  • stuffy nose
Less common:
  • Difficulty having a bowel movement (stool)

For Healthcare Professionals

Applies to riociguat: oral tablet

Cardiovascular

Very common (10% or more): Hypotension (10%)
Frequency not reported: Palpitations, peripheral edema[Ref]

Gastrointestinal

Very common (10% or more): Dyspepsia (21%), gastritis (21%), nausea (14%), diarrhea (12%), vomiting (10%)
Common (1% to 10%): Gastroesophageal reflux disease, constipation
Frequency not reported: Dysphagia, abdominal distention[Ref]

Hematologic

Common (1% to 10%): Anemia[Ref]

Nervous system

Very common (10% or more): Headache (27%), dizziness (20%)[Ref]

Respiratory

Frequency not reported: Nasal congestion, epistaxis[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Adempas (riociguat)." Bayer Pharmaceutical Inc, West Haven, CT.

It is possible that some side effects of riociguat may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Hide