Tadliq Dosage

Generic name: Tadalafil 20mg in 5mL
Dosage form: oral solution
Drug class: Agents for pulmonary hypertension

Medically reviewed by Drugs.com. Last updated on Oct 7, 2024.

Pulmonary Arterial Hypertension

The recommended dose of TADLIQ is 40 mg (10 mL) taken once daily with or without food.

Dose Adjustment in Renal Impairment

Mild (creatinine clearance 51 to 80 mL/min) or moderate (creatinine clearance 31 to 50 mL/min): Start dosing at 20 mg once daily. Increase to 40 mg (10 mL) once daily based on individual tolerability.

Severe (creatinine clearance <30 mL/min and on hemodialysis): Avoid use of TADLIQ because of increased tadalafil exposure (AUC), limited clinical experience, and the lack of ability to influence clearance by dialysis.

Dose Adjustment in Hepatic Impairment

Mild or moderate (Child Pugh Class A or B): Because of limited clinical experience in patients with mild to moderate hepatic cirrhosis, consider a starting dose of 20 mg (5 mL) once per day.

Severe (Child Pugh Class C): Patients with severe hepatic cirrhosis have not been studied. Avoid use of TADLIQ.

Dose Adjustments for Use with Ritonavir

Co-administration of TADLIQ in Patients on Ritonavir

In patients receiving ritonavir for at least one week, start TADLIQ at 20 mg (5 mL) once daily. Increase to 40 mg (10 mL) once daily based upon individual tolerability.

Co-administration of Ritonavir in Patients on TADLIQ

Avoid use of TADLIQ during the initiation of ritonavir. Stop TADLIQ at least 24 hours prior to starting ritonavir. After at least one week following the initiation of ritonavir, resume TADLIQ at 20 mg (5 mL) once daily. Increase to 40 mg (10 mL) once daily based upon individual tolerability.