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Adcirca Side Effects

Generic name: tadalafil

Medically reviewed by Last updated on Mar 29, 2023.

Note: This document contains side effect information about tadalafil. Some dosage forms listed on this page may not apply to the brand name Adcirca.

Applies to tadalafil: oral suspension, oral tablet.

Serious side effects of Adcirca

Along with its needed effects, tadalafil (the active ingredient contained in Adcirca) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tadalafil:

Less common


Incidence not known

Other side effects of Adcirca

Some side effects of tadalafil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common


For Healthcare Professionals

Applies to tadalafil: oral suspension, oral tablet.


The most commonly reported adverse reactions were headache, nausea, dyspepsia, back pain, myalgia, flushing, nasopharyngitis, and pain in the extremity. These adverse reactions were dose dependent, transient, and generally mild or moderate.[Ref]


Very common (10% or more): Flushing (up to 14%)

Common (1% to 10%): Hypertension, hot flush

Uncommon (0.1% to 1%): Hypotension

Frequency not reported: Unstable angina pectoris, postural hypotension, ventricular arrhythmia

Postmarketing reports: Myocardial infarction, sudden cardiac death, stroke, chest pain, palpitations, and tachycardia, have been reported in temporal association with the use of this drug.[Ref]

Most patients that experienced side effects such as myocardial infarction, sudden cardiac death, stroke, palpitations, and tachycardia had preexisting cardiovascular risk factors. Many of these events were reported to occur during or shortly after sexual activity.[Ref]


Very common (10% or more): Dyspepsia (up to 13%), nausea (up to 11%)

Common (1% to 10%): Diarrhea, gastroesophageal reflux disease, abdominal pain, gastroenteritis, constipation

Uncommon (0.1% to 1%): Vomiting

Frequency not reported: Dry mouth, dysphagia, esophagitis, gastritis, loose stools, nausea, upper abdominal pain, hemorrhoidal hemorrhage, rectal hemorrhage[Ref]


Very common (10% or more): Myalgia (up to 14%), back pain (up to 12%), pain in extremity (up to 11%)

Common (1% to 10%): Pain in limb, musculoskeletal stiffness

Uncommon (0.1% to 1%): Arthralgia, muscle spasm

Frequency not reported: Neck pain[Ref]

Nervous system

Very common (10% or more): Headache (up to 42%)

Common (1% to 10%): Dizziness (1%)

Rare (less than 0.1%): Transient global amnesia, transient ischemic attacks

Frequency not reported: Hypesthesia, somnolence, syncope, paraesthesia

Postmarketing reports: Migraine, seizure and seizure recurrence[Ref]


Very common (10% or more): Nasopharyngitis (up to 13%), upper and lower respiratory tract infection (up to 13%)

Common (1% to 10%): Nasal congestion (including sinus congestion), cough, influenza, pulmonary hypertension, rhinitis

Uncommon (0.1% to 1%): Dyspnea, epistaxis

Frequency not reported: Pharyngitis[Ref]


Common (1% to 10%): Urinary tract infection, menorrhagia (including uterine bleeding)

Uncommon (0.1% to 1%): Penile hemorrhage, hematospermia

Rare (less than 0.1%): Prolonged erections

Frequency not reported: Erection increased, spontaneous penile erection

Postmarketing reports: Priapism[Ref]


Common (1% to 10%): Peripheral edema, fatigue, edema

Uncommon (0.1% to 1%): Tinnitus

Rare (less than 0.1%): Facial edema

Frequency not reported: Vertigo, asthenia, pain

Postmarketing reports: Cases of sudden decrease or loss of hearing have been reported in temporal association with the use of this drug.[Ref]

In some of the cases, medical conditions and other factors were reported that may have also played a role in the otologic adverse events. In many cases, medical follow-up information was limited.[Ref]


Uncommon (0.1% to 1%): Rash, urticaria, hyperhidrosis (sweating)

Rare (less than 0.1%): Angioedema

Frequency not reported: Pruritus

Postmarketing reports: Stevens-Johnson syndrome, exfoliative dermatitis[Ref]


Uncommon (0.1% to 1%): Ocular hyperemia, eye pain, eyelid edema

Rare (less than 0.1%): Changes in color vision

Frequency not reported: Blurred vision, conjunctivitis (including conjunctival hyperemia), eye pain, lacrimation increased

Postmarketing reports: Visual field defect, retinal vein occlusion, and retinal artery occlusion. Non-arteritic anterior ischemic optic neuropathy (NAION), a cause of decreased vision including permanent loss of vision, has been reported in temporal association with the use of this drug.[Ref]

Most of the patients with NAION, but not all, had underlying anatomic or vascular risk factors, including but not necessarily limited to: Low cup to disc ratio ("crowded disc"), age over 50, diabetes, hypertension, coronary artery disease, hyperlipidemia, and smoking.[Ref]


Uncommon (0.1% to 1%): Hematuria

Frequency not reported: Renal impairment[Ref]


Frequency not reported: Abnormal liver function tests, GGTP increased[Ref]

Frequently asked questions


1. (2003) "Product Information. Cialis (tadalafil)." Lilly, Eli and Company

2. Cerner Multum, Inc. "UK Summary of Product Characteristics."

3. Cerner Multum, Inc. "Australian Product Information."

4. (2009) "Product Information. Adcirca (tadalafil)." United Therapeutics Corporation

5. Kloner RA, Mitchell M, Emmick JT (2003) "Cardiovascular effects of tadalafil." Am J Cardiol, 92(9 Suppl), p. 37-46

6. Kloner RA, Mitchell M, Emmick JT (2003) "Cardiovascular effects of tadalafil in patients on common antihypertensive therapies." Am J Cardiol, 92(9A), 47M-57M

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.