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Iloprost Side Effects

In Summary

Commonly reported side effects of iloprost include: trismus, increased cough, vasodilatation, and flushing. Other side effects include: glossalgia, and insomnia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to iloprost: inhalation solution

In addition to its needed effects, some unwanted effects may be caused by iloprost. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking iloprost:

Incidence not known:
  • Black, tarry stools
  • chest pain
  • cough
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • hives or rash
  • irregular breathing
  • itching
  • noisy breathing
  • pinpoint red spots on the skin
  • swelling of the eyelids, face, lips, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual bleeding or bruising

Minor Side Effects

Some of the side effects that can occur with iloprost may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • Back pain
  • chills
  • cough increased
  • coughing or spitting up blood
  • difficulty opening the mouth
  • feeling of warmth
  • headache
  • lockjaw
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • sweating
  • trouble sleeping
Less common:
  • Change in taste
  • mouth irritation
  • tongue irritation or pain
Incidence not known:
  • Nosebleeds
  • stuffy nose

For Healthcare Professionals

Applies to iloprost: inhalation solution


The most frequently reported side effects were vasodilation (flushing), cough increased, headache, trismus, insomnia, nausea, hypotension, vomiting, alkaline phosphatase increased, flu syndrome, back pain, tongue pain, palpitations, syncope, GGT increased, muscle cramps, hemoptysis, and pneumonia.[Ref]


Very common (10% or more): Vasodilation/flushing (up to 27%), hypotension (up to 11%)
Common (1% to 10%): Tachycardia, palpitation
Frequency not reported: Congestive heart failure, supraventricular tachycardia[Ref]


Very common (10% or more): Nausea (up to 13%)
Common (1% to 10%): Diarrhea, vomiting, mouth/tongue irritation, mouth/tongue pain
Frequency not reported: Dysgeusia[Ref]

Nervous system

Very common (10% or more): Headache (up to 30%)
Common (1% to 10%): Dizziness, syncope[Ref]


Very common (10% or more): Cough increased (up to 39%), epistaxis, hemoptysis
Common (1% to 10%): Dyspnea, pharyngolaryngeal pain, throat irritation, pneumonia
Frequency not reported: Bronchospasm, wheezing
Postmarketing reports: Nasal congestion[Ref]


Very common (10% or more): Pain in jaw/trismus (up to 12%)
Common (1% to 10%): Back pain, muscle cramps[Ref]


Frequency not reported: Kidney failure[Ref]


Very common (10% or more): Flu-like syndrome (14%), peripheral edema (up to 12.2%), chest discomfort/chest pain
Common (1% to 10%): Alkaline phosphatase increased, GGT increased[Ref]


Common (1% to 10%): Rash[Ref]


Very common (10% or more): Bleeding events
Frequency not reported: Thrombocytopenia[Ref]


Frequency not reported: Hypersensitivity[Ref]


Common (1% to 10%): Insomnia[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Ventavis (iloprost)." Actelion Pharmaceuticals US Inc, South San Francisco, CA.

Not all side effects for iloprost may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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