Generic Name: iloprost inhalation (ill O prost)
Brand Name: Ventavis
Medically reviewed on December 4, 2017
What is iloprost inhalation?
Iloprost inhalation is an synthetic prostacyclin. It works by opening blood vessels in the lungs.
Iloprost inhalation is used to treat pulmonary arterial hypertension (PAH). It decreases symptoms of this condition and improves your ability to exercise.
Iloprost inhalation may also be used for purposes not listed in this medication guide.
Iloprost inhalation is usually given 6 to 9 times per day. Your doses should not be spaced less than 2 hours apart, even if you feel like the effects of the medicine have worn off in less than 2 hours.
Iloprost should be used only with the I-neb ADD System, or the Prodose AAD System. Do not use iloprost inhalation with any other type of nebulizers. You will be shown how to use your nebulizer at home.
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Before taking this medicine
To make sure you can safely use iloprost, tell your doctor if you have other medical conditions, especially:
low blood pressure;
a chest cold or cough.
FDA pregnancy category C. It is not known whether iloprost will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether iloprost passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using iloprost.
How should I use iloprost inhalation?
Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Iloprost inhalation is usually given 6 to 9 times per day. Follow the directions on your prescription label.
Your doses should not be spaced less than 2 hours apart, even if you feel like the effects of the medicine have worn off in less than 2 hours.
Your doctor may occasionally change your dose or daily dosing schedule to make sure you get the best results.
Iloprost is an inhaled medicine that should be used only with the I-neb ADD System, or the Prodose AAD System. Do not use iloprost inhalation with any other type of nebulizers.
You will be shown how to use your nebulizer at home. Your nebulizer system comes with patient instructions for safe and effective use, and for cleaning and care. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Each single-use ampule (bottle) of iloprost inhalation is for one use only. Throw away after one use, even if there is still some medicine left in it after emptying the entire contents into your nebulizer.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.
What should I avoid while using iloprost inhalation?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid getting this medication in your eyes or mouth, or on your skin. If this does happen, rinse with water.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Avoid allowing anyone else to breathe in this medication while you are inhaling your dose, especially children or pregnant women.
Iloprost inhalation side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
feeling like you might pass out;
pounding heartbeats or fluttering in your chest;
unusual bleeding (nosebleeds, bleeding gums);
fever, chills, cough with yellow or green mucus;
chest tightness, stabbing chest pain, wheezing, feeling short of breath; or
anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus, chest pain, fast or uneven heart rate.
Less serious side effects may include:
flushing (warmth, redness, or tingly feeling);
muscle cramps, back pain;
sleep problems (insomnia);
tongue pain, jaw tightness or pain, trouble chewing or speaking; or
altered sense of taste.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Iloprost inhalation dosing information
Usual Adult Dose for Pulmonary Hypertension:
Initial dose: 2.5 mcg inhaled orally once; if tolerated, increase to 5 mcg and maintain this dose
Maintenance dose: 2.5 or 5 mcg inhaled orally 6 to 9 times per day, no more than once every 2 hours while awake, based on individual need and tolerability
Maximum dose: 45 mcg/day (5 mcg/dose 9 times per day)
Comment: Avoid initiation of therapy in patients with systolic blood pressure below 85 mmHg.
Use: For the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to improve a composite endpoint consisting of exercise tolerance, symptoms (New York Heart Association [NYHA] Class), and lack of deterioration. Studies establishing effectiveness included predominately patients with NYHA Functional Class III-IV symptoms and etiologies of idiopathic or heritable PAH (65%) or PAH associated with connective tissue diseases (23%)
What other drugs will affect iloprost inhalation?
Tell your doctor about all other medicines you use, especially:
blood pressure medication;
medication used to prevent blood clots, such as abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrilin), prasugrel (Effient), rivaroxaban (Xarelto), ticlopidine (Ticlid), or tirofiban (Aggrastat).
This list is not complete and other drugs may interact with iloprost inhalation. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Copyright 1996-2018 Cerner Multum, Inc. Version: 3.02.
More about iloprost
- Iloprost Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: agents for pulmonary hypertension
Other brands: Ventavis