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Ventavis Side Effects

Generic Name: iloprost

Note: This document contains side effect information about iloprost. Some of the dosage forms listed on this page may not apply to the brand name Ventavis.

For the Consumer

Applies to iloprost: inhalation solution

Along with its needed effects, iloprost (the active ingredient contained in Ventavis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking iloprost:

Incidence not known
  • Black, tarry stools
  • chest pain
  • cough
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • hives or rash
  • irregular breathing
  • itching
  • noisy breathing
  • pinpoint red spots on the skin
  • swelling of the eyelids, face, lips, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual bleeding or bruising

Some side effects of iloprost may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Back pain
  • chills
  • cough increased
  • coughing or spitting up blood
  • difficulty opening the mouth
  • feeling of warmth
  • headache
  • lockjaw
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • sweating
  • trouble sleeping
Less common
  • Change in taste
  • mouth irritation
  • tongue irritation or pain
Incidence not known
  • Nosebleeds
  • stuffy nose

For Healthcare Professionals

Applies to iloprost: inhalation solution

General

The most frequently reported side effects were vasodilation (flushing), cough increased, headache, trismus, insomnia, nausea, hypotension, vomiting, alkaline phosphatase increased, flu syndrome, back pain, tongue pain, palpitations, syncope, GGT increased, muscle cramps, hemoptysis, and pneumonia.[Ref]

Cardiovascular

Very common (10% or more): Vasodilation/flushing (up to 27%), hypotension (up to 11%)
Common (1% to 10%): Tachycardia, palpitation
Frequency not reported: Congestive heart failure, supraventricular tachycardia[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 13%)
Common (1% to 10%): Diarrhea, vomiting, mouth/tongue irritation, mouth/tongue pain
Frequency not reported: Dysgeusia[Ref]

Nervous system

Very common (10% or more): Headache (up to 30%)
Common (1% to 10%): Dizziness, syncope[Ref]

Respiratory

Very common (10% or more): Cough increased (up to 39%), epistaxis, hemoptysis
Common (1% to 10%): Dyspnea, pharyngolaryngeal pain, throat irritation, pneumonia
Frequency not reported: Bronchospasm, wheezing
Postmarketing reports: Nasal congestion[Ref]

Musculoskeletal

Very common (10% or more): Pain in jaw/trismus (up to 12%)
Common (1% to 10%): Back pain, muscle cramps[Ref]

Renal

Frequency not reported: Kidney failure[Ref]

Other

Very common (10% or more): Flu-like syndrome (14%), peripheral edema (up to 12.2%), chest discomfort/chest pain
Common (1% to 10%): Alkaline phosphatase increased, GGT increased[Ref]

Dermatologic

Common (1% to 10%): Rash[Ref]

Hematologic

Very common (10% or more): Bleeding events
Frequency not reported: Thrombocytopenia[Ref]

Immunologic

Frequency not reported: Hypersensitivity[Ref]

Psychiatric

Common (1% to 10%): Insomnia[Ref]

References

1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Ventavis (iloprost)." Actelion Pharmaceuticals US Inc, South San Francisco, CA.

Some side effects of Ventavis may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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