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Ventavis Side Effects

Generic Name: iloprost

Note: This page contains side effects data for the generic drug iloprost. It is possible that some of the dosage forms included below may not apply to the brand name Ventavis.

In Summary

Common side effects of Ventavis include: trismus, increased cough, vasodilatation, and flushing. Other side effects include: glossalgia, and insomnia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to iloprost: inhalation solution

As well as its needed effects, iloprost (the active ingredient contained in Ventavis) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking iloprost, check with your doctor immediately:

Incidence not known:
  • Black, tarry stools
  • chest pain
  • cough
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • hives or rash
  • irregular breathing
  • itching
  • noisy breathing
  • pinpoint red spots on the skin
  • swelling of the eyelids, face, lips, fingers, feet, or lower legs
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual bleeding or bruising

Minor Side Effects

Some iloprost side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Back pain
  • chills
  • cough increased
  • coughing or spitting up blood
  • difficulty opening the mouth
  • feeling of warmth
  • headache
  • lockjaw
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • sweating
  • trouble sleeping
Less common:
  • Change in taste
  • mouth irritation
  • tongue irritation or pain
Incidence not known:
  • Nosebleeds
  • stuffy nose

For Healthcare Professionals

Applies to iloprost: inhalation solution


The most frequently reported side effects were vasodilation (flushing), cough increased, headache, trismus, insomnia, nausea, hypotension, vomiting, alkaline phosphatase increased, flu syndrome, back pain, tongue pain, palpitations, syncope, GGT increased, muscle cramps, hemoptysis, and pneumonia.[Ref]


Very common (10% or more): Vasodilation/flushing (up to 27%), hypotension (up to 11%)
Common (1% to 10%): Tachycardia, palpitation
Frequency not reported: Congestive heart failure, supraventricular tachycardia[Ref]


Very common (10% or more): Nausea (up to 13%)
Common (1% to 10%): Diarrhea, vomiting, mouth/tongue irritation, mouth/tongue pain
Frequency not reported: Dysgeusia[Ref]

Nervous system

Very common (10% or more): Headache (up to 30%)
Common (1% to 10%): Dizziness, syncope[Ref]


Very common (10% or more): Cough increased (up to 39%), epistaxis, hemoptysis
Common (1% to 10%): Dyspnea, pharyngolaryngeal pain, throat irritation, pneumonia
Frequency not reported: Bronchospasm, wheezing
Postmarketing reports: Nasal congestion[Ref]


Very common (10% or more): Pain in jaw/trismus (up to 12%)
Common (1% to 10%): Back pain, muscle cramps[Ref]


Frequency not reported: Kidney failure[Ref]


Very common (10% or more): Flu-like syndrome (14%), peripheral edema (up to 12.2%), chest discomfort/chest pain
Common (1% to 10%): Alkaline phosphatase increased, GGT increased[Ref]


Common (1% to 10%): Rash[Ref]


Very common (10% or more): Bleeding events
Frequency not reported: Thrombocytopenia[Ref]


Frequency not reported: Hypersensitivity[Ref]


Common (1% to 10%): Insomnia[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Ventavis (iloprost)." Actelion Pharmaceuticals US Inc, South San Francisco, CA.

It is possible that some side effects of Ventavis may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.