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Migraine Medications Compared - Page 2

The medications listed below are related to or used in the treatment of this condition.

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Drug name Rating Reviews Activity ? Rx/OTC Pregnancy CSA Alcohol
Fiorinal 8.6 52 reviews for Fiorinal to treat Migraine
Rx C 3 X
Generic name:
aspirin / butalbital / caffeine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
naratriptan 8.4 49 reviews for naratriptan to treat Migraine
Rx C N
Generic name:
naratriptan systemic
Brand name:
Amerge
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
cyclobenzaprine Off-label 7.6 46 reviews for cyclobenzaprine to treat Migraine
Rx B N X
Generic name:
cyclobenzaprine systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Frova 9.0 41 reviews for Frova to treat Migraine
Rx C N
Generic name:
frovatriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
dihydroergotamine 6.7 37 reviews for dihydroergotamine to treat Migraine
Rx X N
Generic name:
dihydroergotamine systemic
Brand names:
Migranal, D.H.E. 45, Trudhesa
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
cyproheptadine 6.8 35 reviews for cyproheptadine to treat Migraine
Rx B N X
Generic name:
cyproheptadine systemic
Drug class:
antihistamines
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
almotriptan 9.0 33 reviews for almotriptan to treat Migraine
Rx C N
Generic name:
almotriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Amerge 8.4 29 reviews for Amerge to treat Migraine
Rx C N
Generic name:
naratriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Excedrin 6.7 29 reviews for Excedrin to treat Migraine
OTC N N X
Generic name:
acetaminophen / aspirin / caffeine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
lasmiditan 4.6 26 reviews for lasmiditan to treat Migraine
Rx 5
Generic name:
lasmiditan systemic
Brand name:
Reyvow
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
onabotulinumtoxinA 5.8 25 reviews for onabotulinumtoxinA to treat Migraine
Rx C N
Generic name:
onabotulinumtoxinA systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph
caffeine / ergotamine 9.1 23 reviews for caffeine / ergotamine to treat Migraine
Rx X N
Generic name:
caffeine / ergotamine systemic
Brand names:
Cafergot, Migergot
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Reyvow 4.4 22 reviews for Reyvow to treat Migraine
Rx 5
Generic name:
lasmiditan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
venlafaxine Off-label 5.6 22 reviews for venlafaxine to treat Migraine
Rx C N X
Generic name:
venlafaxine systemic
Drug class:
serotonin-norepinephrine reuptake inhibitors
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Migranal 7.4 20 reviews for Migranal to treat Migraine
Rx X N
Generic name:
dihydroergotamine systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Imitrex Statdose 8.4 18 reviews for Imitrex Statdose to treat Migraine
Rx C N
Generic name:
sumatriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
Zomig-ZMT 8.5 17 reviews for Zomig-ZMT to treat Migraine
Rx C N X
Generic name:
zolmitriptan systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
Cafergot 8.5 13 reviews for Cafergot to treat Migraine
Rx X N
Generic name:
caffeine / ergotamine systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
orphenadrine Off-label 6.4 11 reviews for orphenadrine to treat Migraine
Rx C N X
Generic name:
orphenadrine systemic
Drug class:
skeletal muscle relaxants
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
methylergonovine Off-label 9.8 10 reviews for methylergonovine to treat Migraine
Rx C N
Generic name:
methylergonovine systemic
Brand name:
Methergine
Drug class:
uterotonic agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
acetaminophen / aspirin / caffeine / salicylamide 9.9 9 reviews for acetaminophen / aspirin / caffeine / salicylamide to treat Migraine
Rx/OTC N N X
Generic name:
acetaminophen / aspirin / caffeine / salicylamide systemic
Brand name:
Painaid
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
Goody's Headache Powders 6.3 9 reviews for Goody's Headache Powders to treat Migraine
OTC N N X
Generic name:
acetaminophen / aspirin / caffeine systemic
Drug class:
analgesic combinations
For consumers:
dosage, interactions, side effects
memantine Off-label 7.2 9 reviews for memantine to treat Migraine
Rx B N
Generic name:
memantine systemic
Drug class:
miscellaneous central nervous system agents
For consumers:
dosage, interactions, side effects
For professionals:
AHFS DI Monograph, Prescribing Information
Off-label:
Yes
Methergine Off-label 9.7 8 reviews for Methergine to treat Migraine
Rx C N
Generic name:
methylergonovine systemic
Drug class:
uterotonic agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information
Off-label:
Yes
D.H.E. 45 6.9 7 reviews for D.H.E. 45 to treat Migraine
Rx X N
Generic name:
dihydroergotamine systemic
Drug class:
antimigraine agents
For consumers:
dosage, interactions, side effects
For professionals:
Prescribing Information

Frequently asked questions

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Topics under Migraine

Learn more about Migraine

Care guides

Symptoms and treatments

Medicine.com guides (external)

Legend

Rating For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective).
Activity Activity is based on recent site visitor activity relative to other medications in the list.
Rx Prescription only.
OTC Over-the-counter.
Rx/OTC Prescription or Over-the-counter.
Off-label This medication may not be approved by the FDA for the treatment of this condition.
EUA An Emergency Use Authorization (EUA) allows the FDA to authorize unapproved medical products or unapproved uses of approved medical products to be used in a declared public health emergency when there are no adequate, approved, and available alternatives.
Expanded Access Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.
Pregnancy Category
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act (CSA) Schedule
M The drug has multiple schedules. The schedule may depend on the exact dosage form or strength of the medication.
U CSA Schedule is unknown.
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

Further information

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