Skip to Content

User Reviews for Dihydroergotamine to treat Migraine

Also known as: Migranal, D.H.E. 45, Trudhesa

Dihydroergotamine has an average rating of 6.5 out of 10 from a total of 29 ratings for the treatment of Migraine. 59% of reviewers reported a positive effect, while 31% reported a negative effect.

Dihydroergotamine Rating Summary

6.5/10 average rating

29 ratings from 30 user reviews.

Compare all 130 medications used in the treatment of Migraine.

10
28%
9
21%
8
10%
7
3%
6
7%
5
0%
4
0%
3
3%
2
0%
1
28%

Reviews for Dihydroergotamine

Anonymous February 3, 2011

Migranal (dihydroergotamine): “I give it a 10 because I was about to jump off a bridge in order to break the 18 day migraine I had up until this morning. It took 3 days of Migranal but I am FINALLY through the pain. I tried two rounds of steriods, Maxalt up to 3x's/day for 2 weeks, and FINALLY this worked. Although I am cautiously optimistic, this is the longest I have gone in 18 days without the debilitating pain that became so severe I was willing to go to very extreme measures to get it to stop. Thank goodness my Neurologist thought of it.”

10 / 10
Was this helpful?YesNo
jaxncadensmommy July 17, 2013

Migranal (dihydroergotamine): “I have been suffering from migraines for about 2 years now. I've tried a few different prescription pills and I've suffered from horrible side effects from each one. I was to the point where I felt almost hopeless because I couldn't do anything to relieve the pain when I would get migraines. My neurologist prescribed me Migrainal last month and I've had 3 horrible migraines since then. Each time I have used Migrainal within 30 minutes they are gone and I feel great and not defeated by the horrible migraine. I definitely would recommend and consider this a miracle!”

10 / 10
Was this helpful?YesNo
Anonymous January 18, 2012

Migranal (dihydroergotamine): “I have been getting severe migraines for more than 25 years. 99% of the time they would result in a trip to the ER for a few injections - since I can't keep anything in my stomach, pills were not a solution. Suppositories to control the vomiting so that I could take pills only made me more miserable - in other ways - and offered little to no benefit. Last year my neurologist prescribed Migranal Nasal Spray. Wow. What a life changer! Within 30 minutes I am good to go with little to no remaining headache. There isn't even enough time for the vomiting to start. I really want to spread the word on this to other migraine sufferers. It has been an amazing solution for me.”

10 / 10
Was this helpful?YesNo
michellerand2001 April 5, 2008

Migranal (dihydroergotamine): “Works well to treat migraines but you really need to rest after taking. I get an unpleasant burning sensation in nose, sinuses and throat, but still worth taking. Also, the bottle is a pain in the butt to assemble - especially when you have a migraine. I have frequent severe migraines (about 4 times a week) and this medicine is helpful although my dr. said it should not be used more than twice a week. I am allergic to all the triptans, so this medicine has been a good alternative treatment.”

8 / 10
Was this helpful?YesNo
Anonymous · Taken for 1 to 2 years September 24, 2012

Migranal (dihydroergotamine): “Taste in mouth, burning in throat, stuffy nose and nausea which all passed after an hour. Medication effective within 60-90 minutes. Very effective and less expensive than a trip to ER to receive DHE intravenously. TAKE A ZOFRAN!”

9 / 10
Was this helpful?YesNo
JLHelm June 1, 2013

Migranal (dihydroergotamine): “This medication is a miracle for me! I have had migraines for 26 years and tried just about everything. My neurologist prescribed this in an attempt to get rid of a 3 week migraine. I took the spray as directed and within an hour I was headache free. I have no side effects, no bad taste, nothing. It is truly my miracle!”

10 / 10
Was this helpful?YesNo
owka4u · Taken for 10 years or more March 26, 2014

Migranal (dihydroergotamine): “I have Celiac disease and one of the side effects are migraines that use to last 3 or days until I found DHE 45 which was 1st done by IV. After that I was prescribed the shots until the nasal spray came out. After 15 years of research on my own I have come to the conclusion that either Celiac or other allergens are the prime cause of migraines that last more then 24 hours and maybe those as well; for these conditions cause swelling in every cell in the body including the neurons. I hope this helps others who suffer from the debilitating pain caused by these episodes.”

10 / 10
Was this helpful?YesNo
MNWalsh · Taken for 6 months to 1 year December 27, 2013

Migranal (dihydroergotamine): “My Doctor prescribed me Migranal earlier this year. I've had migraines since I was 6 and have never found anything that helps this much. I prefer the pill I can take over the spray. I've been to the ER before and they give me DHE (Migranal) in an I.V shot and it's magic. Look into this if you need help.”

8 / 10
Was this helpful?YesNo
RobinR February 21, 2012

Migranal (dihydroergotamine): “My neurologist prescribed the Migranal for me last year when I got into a 2 mth long migraine that was seeming to be impossible to break. I'm also on Nortryptiline and Atenolol as preventatives and the Migranal is for PRN usage. (as needed) As someone else said, this drug does seem to work the best if you use it at the first sign of migraine. If you wait until your migraine is fully set in, it doesn't seem to work all that well. The downside to the medicine is that is does leave a terrible taste in your mouth, your throat burns, and your nose gets stuffed up. But compared the to severe pain of a migraine, I guess it's worth it. The worst part about it though is the COST.”

Was this helpful?YesNo
Don't do it · Taken for 5 to 10 years November 28, 2016

Migranal (dihydroergotamine): “This drug DAMN near killed me.. took as prescribed with in minutes I was confused and lost consciousness.. ended up in the ED . Woke up the next day with my face swollen double its size and having no idea what happened to me... DO NOT TAKE THIS MEDICATION!!!”

1 / 10
Was this helpful?YesNo
ashubina January 16, 2009

Migranal (dihydroergotamine): “I have migraines usually 3 to 5 times a week and my neurologist gave me this medicine. I am also taking propranolol and have not noted any side effects. I have found that for me it works best when taken at first signs of a migraine. If I take it when I already have a migraine it doesn't work. There is a little nausea afterward but a little food helps. It's a very effective treatment and no rebound headaches.”

9 / 10
Was this helpful?YesNo
Mainah February 20, 2020

Migranal (dihydroergotamine): “Triptans unfortunately stopped working for me so, I decided to try this. First time I took it cut down my migraine by about 50%. Second time cut it down about 90%! Even helped my neck pain. Slight break through pain but much better. I just hope it keeps working! Only side effects I’ve noticed are tiredness and bad taste. Much better than a migraine.”

8 / 10
Was this helpful?YesNo
Laurel Kaufman October 8, 2019

Migranal (dihydroergotamine): “This is my first dose of Migranal. I just went to a new neurologist this morning and he gave me a sample. I have a slightly funny taste in my mouth but I think it's because my nose is stuffed from the Migranal. No signs of the horrible migraine monster yet, and the first signs of it have stopped. I get debilitatingly severe migraine headaches with panic/anxiety attacks. Triptans have not been reliable and I cannot afford to pay for a trip to the ER that many times a week. So far so good, nausea and stuffy, but that's a vacation to one of my headaches!”

9 / 10
Was this helpful?YesNo
MariaMMB January 23, 2016

Migranal (dihydroergotamine): “I had chronic severe migraines almost daily for 25 years. Some things have sort of worked; most not. Botox made an enormous difference in my headaches. I have been using Migranal for breakthrough headaches and life is very much better. This year, Migranal, nor its generic (which are made by the same company??), are covered under my insurance. I have Medicare, and I receive Social Security Disability. The generic cost is more than my whole SSD check. MY neurologist and pharmacists are out of suggestions. They say maybe I can ask for Patient Assistance Coverage, which almost always is only given to people who already have some kind of drug coverage. Or maybe the doctor can give me samples. I am horrified.”

7 / 10
Was this helpful?YesNo
Amelia December 11, 2019

“At 11 years old, I experienced severe and constant migraines that took me totally out of school and out of life. The drug Topiramate helped me cope for months, but then I was moved to the Neurology Hospital Dept where they first injected me with DHE (dihydroergotamine). Within seconds, I lost all vision and could not breathe at all- I thought for SURE- I am that was it. All Doctors sprinted into the room and one injected me with Benadryl and other anti inflammatories, which is what saved my life. This is not a drug to test unless you have tested all avenues. At 11 years old, my mom watched me slip into unconsciousness and further into oblivion, until my life was saved. Do NOT let this be you. I have worn a medical bracelet everyday since this occurrence. I have absolutely NO allergies to the outside world, but do not doubt that this drug can be your first and LAST experience with a bad allergy. PLEASE, be careful and especially WITH YOUR CHILDREN.”

1 / 10
Was this helpful?YesNo
sherrylblake September 3, 2009

Migranal (dihydroergotamine): “Migranal Nasal Spray seems to have helped the migraine (within the 24 hours, not quickly). However, the muscle pain was tremendous for 48 hours following taking the 1st & 2nd doses. I changed from Triptans because of the muscle pain, but the pain with the Migranal is worse. I will try it one more time, but if the after effect (excruciating muscle pain, especially in my legs and feet) are as bad as my first experience, I will stop.”

6 / 10
Was this helpful?YesNo
Honey17 January 27, 2012

D.H.E. 45 (dihydroergotamine): “I've been experiencing migraines for over 30 years. I started injecting DHE 9 days ago and haven't had a single migraine. This hasn't happened since I started getting migraines and I've been on many medications including Botox. I don't expect to never get another migraine but I'm enjoying this time while it lasts. I do believe that the DHE will control my migraines and keep them to a minimum which has never been done before. I normally average 25 migraines a month. If DHE can reduce my migraines to once a week, I'll be thrilled.”

10 / 10
Was this helpful?YesNo
Cataleyaa July 1, 2014

“If you suffer from an anxiety disorder or depression, I would be very cautious with this medication. I suffer from chronic migraines and anxiety and depression, and was given DHE on multiple occasions for my acute migraines. As soon as the medication entered my body, I felt restless and anxious. Within 2 minutes, I was having a full-on panic attack; I was completely terrified even though I knew I was entirely safe. The horror consumed me & I lost my perspective and was convinced that I would feel that way for the rest of my life. I felt so hopeless that I couldn't bring myself to ask the doctor for help. It did help with the acute head pain, but it left me so terrified and anxious that I was back in the ER within 2 days for another migraine”

1 / 10
Was this helpful?YesNo
AZ ill · Taken for 10 years or more May 3, 2015

“Hi All, Is there anyone else who has experienced a huge increase in cost for DHE mesylate (injectable vial)? I have injected with DHE 45 and now DHE mesylate for 17 yrs since my brain aneurysm rupture and clipping. As of Jan 2015 United Health Insurance along with Optum RX have raised my cost from $25 for a 90 day supply to $1500 to $1700 and this is my cost. Unable to afford this medication any longer I am left helpless. thanks for any input regarding similar price hikes.”

6 / 10
Was this helpful?YesNo
Susan G. October 23, 2012

D.H.E. 45 (dihydroergotamine): “I have had migraines for 30 years. In the last year and a half they went from 15 day/month to practically every day. Triptans do not work as an abortive for me. Propananol is the only preventative thus far that has worked - but it stopped working after 4 weeks. My neurologist prescribed DHE in the injectible form. I do not like the little glass vials the DHE comes in, breaking them open, and using the syringe. That said, almost every time I use it, it breaks the migraine. Unfortunately, it does not always last more than 4-6 hours. I can get this at my local CVS (though they don't carry it in stock). I don't notice any side-effects but I generally take a nap afterward to let it do it's thing.”

9 / 10
Was this helpful?YesNo
davismom3 · Taken for less than 1 month April 6, 2018

D.H.E. 45 (dihydroergotamine): “My daughter received this medication through IV while in the hospital. Within 15 minutes after receiving the fifth dose her vision became significantly altered. We demanded subsequent doses be stopped. She now has 20/200 near vision and slightly altered far vision. At age 13 she stared wearing bifocals. Her ophthalmologist now has after two years without improvement determined that DHE caused her significantly impaired vision. Please be aware of this side effect prior to taking this drug.”

1 / 10
Was this helpful?YesNo
Mollie_T February 1, 2009

Migranal (dihydroergotamine): “My neurologist gave me a sample of this spray during my last office visit. We're going the non-Triptan route trying to manage my migraines since I previously had a reaction to Triptans. This spray did nothing for my latest migraine at all. In it's defense my migraines are pretty severe and even hard core narcotics aren't much of a match for them. The search continues.”

1 / 10
Was this helpful?YesNo
Joe with no migraines December 9, 2017

Migranal (dihydroergotamine): “Migranal works for me 100% of the time, although somewhat slow acting (1-3 hours). I used to get migraines about once a week, with duration of 1-3 days, sometimes severe. For the past 3 years, I have been taking 10 mg of amitriptyline at night, and 37.5/25 mg triamterene/HCTZ in the morning. Under this program, I get the beginning of a migraine about once every 1-3 months, and these events have been 100% controlled by Migranal. Btw, the addition of triamterene/HCTZ was for Meniere's syndrome, and the effect on migraine was a positive, unexpected side effect (amitriptylene alone had reduced the migraines to about 1-2 per month).”

10 / 10
Was this helpful?YesNo
Managing with headaches December 19, 2015

“I have used Migranal for years, but now the expense is very high. The medicine works well for me as well. The only reason for the cost is gouging by the drug companies that make this medicine. It is an old medication and the money they charge for it is not related to the cost of research or production. They charge this much because this country lets them get away with it. No other western country lets drug companies charge what they want for medicines. They should not be allowed to do it in the U.S. either. It is criminal.”

9 / 10
Was this helpful?YesNo
Anonymous March 16, 2009

D.H.E. 45 (dihydroergotamine): “I have had severe migraines for years. I finally was put on Topamax about a year ago but that wasn't enough, I still had attacks that kept me from doing anything about 2 times a months. None of the triptans worked so my doctor finally suggested DHE injections. She taught me to give them to myself so I can do them at home and now I can stop a migraine when it starts and not miss work for days on end. If anything I miss one day here and there.”

9 / 10
Was this helpful?YesNo

This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.

Learn more about Migraine

IBM Watson Micromedex

Symptoms and treatments

Mayo Clinic Reference