Orphenadrine Dosage
Medically reviewed by Drugs.com. Last updated on Aug 9, 2023.
Applies to the following strengths: 100 mg; 30 mg/mL
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Muscle Spasm
Extended-Release Tablets: 100 mg orally twice a day
Parenteral Injection: 60 mg IV or IM every 12 hours as needed
Use: As an adjunct to rest, physical therapy and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions.
Renal Dose Adjustments
No adjustment recommended
Liver Dose Adjustments
No adjustment recommended
Dose Adjustments
Elderly: Dose reduction should be considered, especially for patients with mental confusion
Precautions
CONTRAINDICATIONS:
- Hypersensitivity to active substance or any product excipients
- Glaucoma
- Pyloric or duodenal obstruction
- Stenosing peptic ulcers
- Prostatic hypertrophy or obstruction of the bladder neck
- Cardio-spasm (megaesophagus)
- Myasthenia gravis
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
Extended-release Tablets:
- Swallow whole; do not crush or chew
- Take orally twice a day, morning and evening
Injectable Therapy:
- For IV and IM administration; do not administer subcutaneously
General:
- This drug has been abused for its euphoric effects; mood elevating effects may occur at therapeutic doses.
- The parenteral product contains sodium metabisulfite; this may cause allergic-type reactions in susceptible patients; asthmatic patients are more likely to be sulfite sensitive.
Monitoring:
- Periodic monitoring of blood, urine, and liver function is recommended with prolonged use
Patient advice:
- Patients should understand that this drug may impair their mental and/or physical abilities to perform hazardous tasks such as driving, and they should be counseled appropriately.
- Patients should be instructed to speak with their healthcare provider if they are pregnant, intending to become pregnant or breastfeeding.
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Patient resources
- Orphenadrine drug information
- Orphenadrine (Injection) (Advanced Reading)
- Orphenadrine (Oral) (Advanced Reading)
- Orphenadrine Extended-Release Tablets
- Orphenadrine Injection
Other brands
Norflex, Antiflex, Mio-Rel, Orfro, Orphenate
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
