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Orphenadrine Dosage

Medically reviewed by Last updated on Aug 9, 2023.

Applies to the following strengths: 100 mg; 30 mg/mL

Usual Adult Dose for Muscle Spasm

Extended-Release Tablets: 100 mg orally twice a day

Parenteral Injection: 60 mg IV or IM every 12 hours as needed

Use: As an adjunct to rest, physical therapy and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions.

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

Dose Adjustments

Elderly: Dose reduction should be considered, especially for patients with mental confusion



  • Hypersensitivity to active substance or any product excipients
  • Glaucoma
  • Pyloric or duodenal obstruction
  • Stenosing peptic ulcers
  • Prostatic hypertrophy or obstruction of the bladder neck
  • Cardio-spasm (megaesophagus)
  • Myasthenia gravis

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:
Extended-release Tablets:

  • Swallow whole; do not crush or chew
  • Take orally twice a day, morning and evening

Injectable Therapy:
  • For IV and IM administration; do not administer subcutaneously

  • This drug has been abused for its euphoric effects; mood elevating effects may occur at therapeutic doses.
  • The parenteral product contains sodium metabisulfite; this may cause allergic-type reactions in susceptible patients; asthmatic patients are more likely to be sulfite sensitive.

  • Periodic monitoring of blood, urine, and liver function is recommended with prolonged use

Patient advice:
  • Patients should understand that this drug may impair their mental and/or physical abilities to perform hazardous tasks such as driving, and they should be counseled appropriately.
  • Patients should be instructed to speak with their healthcare provider if they are pregnant, intending to become pregnant or breastfeeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.