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Methylergonovine Side Effects

For the Consumer

Applies to methylergonovine: oral tablet

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by methylergonovine. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking methylergonovine:

More common:
  • Abdominal pain
  • headache
  • increased blood pressure
  • Blood in the urine
  • change in skin color
  • chest pain or discomfort
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • lightheadedness, dizziness, or fainting
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, tenderness, or swelling of the foot or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • slow or fast heartbeat
  • skin rash
  • sweating
  • vomiting
Incidence not known:
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • inability to speak
  • seizures
  • severe or sudden headache
  • slurred speech
  • temporary blindness
  • weakness in the arm or leg on one side of the body, sudden and severe

Minor Side Effects

Some of the side effects that can occur with methylergonovine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

  • Continuous ringing or buzzing or other unexplained noise in the ears
  • cramps in the legs
  • diarrhea
  • foul taste
  • increased sweating
  • nausea
  • stuffy nose

For Healthcare Professionals

Applies to methylergonovine: injectable solution, oral tablet


Cardiovascular side effects have included palpitations, hypertension, hypotension, acute myocardial infarction, transient chest pains, arterial spasm (coronary and peripheral), bradycardia, and tachycardia. Postmarketing reports have included ventricular fibrillation, ventricular tachycardia, angina pectoris and atrioventricular block.[Ref]


Hematologic side effects have included thrombophlebitis.[Ref]


Metabolic side effects have included water intoxication.[Ref]

Nervous system

Nervous system side effects have included tinnitus, hallucinations and dizziness. Postmarketing reports have included cerebrovascular accident and paraesthesia.[Ref]


Gastrointestinal side effects have included diarrhea, foul taste, nausea and vomiting.[Ref]


Dermatologic side effects have included diaphoresis and rash.[Ref]


Genitourinary side effects have included hematuria.[Ref]


Respiratory side effects have included dyspnea and nasal congestion.[Ref]


1. "Product Information. Methergine (methylergonovine)." Allscripts Healthcare Solutions, Chicago, IL.

Not all side effects for methylergonovine may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.