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Methylergonovine Side Effects

For the Consumer

Applies to methylergonovine: oral tablet

Other dosage forms:

Along with its needed effects, methylergonovine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methylergonovine:

More common
  • Blood in the urine
  • change in skin color
  • chest pain or discomfort
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • lightheadedness, dizziness, or fainting
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, tenderness, or swelling of the foot or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • slow or fast heartbeat
  • skin rash
  • sweating
  • vomiting
Incidence not known
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • inability to speak
  • seizures
  • severe or sudden headache
  • slurred speech
  • temporary blindness
  • weakness in the arm or leg on one side of the body, sudden and severe

Some side effects of methylergonovine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

  • Continuous ringing or buzzing or other unexplained noise in the ears
  • cramps in the legs
  • diarrhea
  • foul taste
  • increased sweating
  • nausea
  • stuffy nose

For Healthcare Professionals

Applies to methylergonovine: injectable solution, oral tablet


Cardiovascular side effects have included palpitations, hypertension, hypotension, acute myocardial infarction, transient chest pains, arterial spasm (coronary and peripheral), bradycardia, and tachycardia. Postmarketing reports have included ventricular fibrillation, ventricular tachycardia, angina pectoris and atrioventricular block.[Ref]


Hematologic side effects have included thrombophlebitis.[Ref]


Metabolic side effects have included water intoxication.[Ref]

Nervous system

Nervous system side effects have included tinnitus, hallucinations and dizziness. Postmarketing reports have included cerebrovascular accident and paraesthesia.[Ref]


Gastrointestinal side effects have included diarrhea, foul taste, nausea and vomiting.[Ref]


Dermatologic side effects have included diaphoresis and rash.[Ref]


Genitourinary side effects have included hematuria.[Ref]


Respiratory side effects have included dyspnea and nasal congestion.[Ref]


1. "Product Information. Methergine (methylergonovine)." Allscripts Healthcare Solutions, Chicago, IL.

Some side effects of methylergonovine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.