Excedrin Interactions
There are 579 drugs known to interact with Excedrin (acetaminophen/aspirin/caffeine), along with 21 disease interactions, and 6 alcohol/food interactions. Of the total drug interactions, 72 are major, 433 are moderate, and 74 are minor.
- View all 579 medications that may interact with Excedrin
- View Excedrin alcohol/food interactions (6)
- View Excedrin disease interactions (21)
Most frequently checked interactions
View interaction reports for Excedrin (acetaminophen / aspirin / caffeine) and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- albuterol
- Aleve (naproxen)
- aspirin
- atorvastatin
- Benadryl (diphenhydramine)
- bupropion
- cyclobenzaprine
- famotidine
- Fish Oil (omega-3 polyunsaturated fatty acids)
- gabapentin
- hydroxyzine
- ibuprofen
- levothyroxine
- lisinopril
- magnesium oxide
- melatonin
- metformin
- omeprazole
- pantoprazole
- prednisone
- propranolol
- tramadol
- trazodone
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Zyrtec (cetirizine)
Excedrin alcohol/food interactions
There are 6 alcohol/food interactions with Excedrin (acetaminophen / aspirin / caffeine).
Excedrin disease interactions
There are 21 disease interactions with Excedrin (acetaminophen / aspirin / caffeine) which include:
- alcoholism
- liver disease
- coagulation
- cardiac disease
- hypertension
- psychiatric disorders
- PUD
- asthma
- GI toxicity
- renal dysfunction
- Reye's syndrome
- PKU
- cardiotoxicity
- liver disease
- renal dysfunction
- seizure disorders
- GERD
- anemia
- dialysis
- G-6-PD deficiency
- hepatotoxicity
Report options
More about Excedrin (acetaminophen / aspirin / caffeine)
- Excedrin consumer information
- Compare alternatives
- Reviews (39)
- Latest FDA alerts (5)
- Side effects
- Dosage information
- During pregnancy
- Support group
- Drug class: analgesic combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.