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Methergine Side Effects

Generic name: methylergonovine

Medically reviewed by Last updated on Aug 16, 2022.

Note: This document contains side effect information about methylergonovine. Some dosage forms listed on this page may not apply to the brand name Methergine.

Applies to methylergonovine: oral tablet. Other dosage forms:

Serious side effects of Methergine

Along with its needed effects, methylergonovine (the active ingredient contained in Methergine) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methylergonovine:

More common


  • Blood in the urine
  • change in skin color
  • chest pain or discomfort
  • difficult or labored breathing
  • difficulty with swallowing
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • lightheadedness, dizziness, or fainting
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, tenderness, or swelling of the foot or leg
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • slow or fast heartbeat
  • skin rash
  • sweating
  • vomiting

Incidence not known

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • inability to speak
  • seizures
  • severe or sudden headache
  • slurred speech
  • temporary blindness
  • weakness in the arm or leg on one side of the body, sudden and severe

Other side effects of Methergine

Some side effects of methylergonovine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  • Continuous ringing or buzzing or other unexplained noise in the ears
  • cramps in the legs
  • diarrhea
  • foul taste
  • increased sweating
  • nausea
  • stuffy nose

For Healthcare Professionals

Applies to methylergonovine: injectable solution, oral tablet.


The most commonly reported adverse reaction is hypertension.


Frequency not reported: Hypertension, hypotension, palpitations, acute myocardial infarction, transient chest pains, arterial spasm (coronary and peripheral), bradycardia, tachycardia

Postmarketing reports: Ventricular fibrillation, ventricular tachycardia, angina pectoris, atrioventricular block[Ref]

Nervous system

Frequency not reported: Headache, dizziness, seizure

Postmarketing reports: Cerebrovascular accident, paraesthesia[Ref]


Frequency not reported: Thrombophlebitis[Ref]


Frequency not reported: Hematuria, abdominal pain associated with uterine contractions[Ref]


Frequency not reported: Water intoxication[Ref]


Frequency not reported: Diarrhea, foul taste, nausea, vomiting[Ref]


Frequency not reported: Dyspnea, nasal congestion[Ref]


Frequency not reported: Hallucinations


Frequency not reported: Diaphoresis, rash[Ref]


Frequency not reported: Leg cramps


Frequency not reported: Tinnitus


Frequency not reported: Anaphylaxis (no proven causal relationship)


1. "Product Information. Methergine (methylergonovine)." Novartis Pharmaceuticals (2010):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.