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Medications for Bipolar Disorder

Other names: Bipolar Affective Disorder; Bipolar Affective Mood Disorder; Bipolar I Disorder; Bipolar II Disorder; Manic Depression; Manic Depressive Disorder; Manic Depressive Illness; Mood Disorder

What is Bipolar Disorder:  Bipolar disorder is characterized by periods of excitability (mania) alternating with periods of depression. The "mood swings" between mania and depression are often very abrupt.

Medications to treat Bipolar Disorder

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
lamotrigine Rx C N X 540 reviews
8.0

Generic name: lamotrigine systemic

Brand names:  Lamictal, Lamictal ODT, Lamictal CD

Drug class: triazine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
lithium Rx D N X 198 reviews
7.0

Generic name: lithium systemic

Brand name:  Lithobid

Drug class: miscellaneous antipsychotic agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
clonazepam Off Label Rx D 4 X 78 reviews
8.0

Generic name: clonazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
quetiapine Rx C N X 398 reviews
7.0

Generic name: quetiapine systemic

Brand names:  Seroquel, Seroquel XR

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
divalproex sodium Rx D N X 161 reviews
6.0

Generic name: divalproex sodium systemic

Brand names:  Depakote, Depakote ER, Depakote Sprinkles

Drug class: fatty acid derivative anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
gabapentin Off Label Rx C N X 83 reviews
8.0

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
bupropion Off Label Rx C N X 41 reviews
6.0

Generic name: bupropion systemic

Drug class: miscellaneous antidepressants, smoking cessation agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
sertraline Off Label Rx C N X 31 reviews
7.0

Generic name: sertraline systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
risperidone Rx C N X 99 reviews
6.0

Generic name: risperidone systemic

Brand names:  Risperdal, Risperdal Consta, Risperdal M-Tab

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
topiramate Off Label Rx D N X 89 reviews
7.0

Generic name: topiramate systemic

Drug class: carbonic anhydrase inhibitor anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
carbamazepine Rx D N X 84 reviews
7.0

Generic name: carbamazepine systemic

Brand name:  Equetro

Drug class: dibenzazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
oxcarbazepine Off Label Rx C N X 100 reviews
8.0

Generic name: oxcarbazepine systemic

Drug class: dibenzazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
venlafaxine Off Label Rx C N X 51 reviews
6.0

Generic name: venlafaxine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
citalopram Off Label Rx C N X 6 reviews
7.0

Generic name: citalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
olanzapine Rx C N X 139 reviews
6.0

Generic name: olanzapine systemic

Brand names:  Zyprexa, Zyprexa Zydis, Zyprexa Intramuscular

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
aripiprazole Rx C N X 223 reviews
5.0

Generic name: aripiprazole systemic

Brand name:  Abilify

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
clonidine Off Label Rx C N X 6 reviews
6.0

Generic name: clonidine systemic

Drug class: antiadrenergic agents, centrally acting

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
duloxetine Off Label Rx C N X 32 reviews
6.0

Generic name: duloxetine systemic

Drug class: serotonin-norepinephrine reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
escitalopram Off Label Rx C N X 34 reviews
7.0

Generic name: escitalopram systemic

Drug class: selective serotonin reuptake inhibitors

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
ziprasidone Rx C N X 168 reviews
5.0

Generic name: ziprasidone systemic

Brand name:  Geodon

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
valproic acid Off Label Rx D N X 12 reviews
6.0

Generic name: valproic acid systemic

Drug class: fatty acid derivative anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

Off Label: Yes

 
fluoxetine / olanzapine Rx C N X 32 reviews
8.0

Generic name: fluoxetine / olanzapine systemic

Brand name:  Symbyax

Drug class: psychotherapeutic combinations

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, Prescribing Information

 
levetiracetam Off Label Rx C N X 5 reviews
6.0

Generic name: levetiracetam systemic

Drug class: pyrrolidine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
lurasidone Rx B N X 376 reviews
6.0

Generic name: lurasidone systemic

Brand name:  Latuda

Drug class: atypical antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
perphenazine Off Label Rx N N X 8 reviews
7.0

Generic name: perphenazine systemic

Drug class: phenothiazine antiemetics, phenothiazine antipsychotics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
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Topics under Bipolar Disorder

Learn more about Bipolar Disorder

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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