What is loxapine?
Loxapine is an antipsychotic medication that is used to treat schizophrenia.
Loxapine may also be used for purposes not listed in this medication guide.
Loxapine side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
High doses or long-term use of loxapine can cause a serious movement disorder that may not be reversible. The longer you use loxapine, the more likely you are to develop this disorder, especially if you are a woman or an older adult.
Loxapine may cause serious side effects. Call your doctor at once if you have:
uncontrolled muscle movements in your arms or legs, or your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
a light-headed feeling, like you might pass out;
confusion, slurred speech;
agitation, trouble sleeping;
little or no urinating;
severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
Common side effects of loxapine may include:
dizziness, problems with balance or walking;
swelling in your face;
tremors, muscle twitching or stiffness;
feeling restless or agitated;
dry mouth, stuffy nose; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
You should not use loxapine if you have decreased alertness caused by taking certain medications or drinking alcohol.
Before taking this medicine
You should not use loxapine if you are allergic to loxapine or amoxapine, or if you have decreased alertness caused by taking certain medications or drinking alcohol.
Loxapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.
Tell your doctor if you have ever had:
epilepsy or other seizure disorder;
low white blood cell (WBC) counts;
blockage in your digestive tract (stomach or intestines);
heart disease; or
Tell your doctor if you are pregnant or you get pregnant. Using antipsychotic medication during the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn.
You should not breastfeed while using loxapine.
How should I take loxapine?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
You may not start feeling better right away when you start taking loxapine. Call your doctor if your symptoms do not improve, or if they get worse while using loxapine.
Store at room temperature away from moisture, heat, and light.
Loxapine dosing information
Usual Adult Dose for Schizophrenia:
Initial Dose: 10 mg orally twice a day
-Initial doses of up to 50 mg a day may be needed in severely disturbed patients
Titrate rapidly over the first 7 to 10 days until symptoms are effectively controlled
Maintenance Dose: 60 mg to 100 mg daily in divided doses, 2 to 4 times a day
Maximum dose: 250 mg/day
-Daily dosage should be adjusted to the individual patient's needs based on severity of symptoms and previous antipsychotic drug response.
-Usual therapeutic and maintenance range is 60 to 100 mg daily; however, some patients may respond to lower, and others higher, doses.
-For maintenance therapy, 20 to 60 mg has been satisfactory for a majority of patients.
Use: For the treatment of schizophrenia
Usual Adult Dose for Agitated State:
10 mg by oral inhalation once within a 24-hour period
-To mitigate the risk of bronchospasm, all patients must undergo screening and examination prior to administration.
-This drug must be administered by a healthcare professional only in an enrolled healthcare facility.
Use: For the acute treatment of agitation associated with schizophrenia or bipolar I disorder
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include weak or shallow breathing, fainting, or seizure (convulsions).
What should I avoid while taking loxapine?
Avoid driving or operating machinery until you know how loxapine will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.
Avoid drinking alcohol. Dangerous side effects could occur.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Loxapine can decrease perspiration and you may be more prone to heat stroke.
What other drugs will affect loxapine?
Taking loxapine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Other drugs may affect loxapine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
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Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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