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Adasuve Inhalation

Generic name: loxapine (inhalation) [ LOX-a-peen ]
Brand name: Adasuve
Drug class: Miscellaneous antipsychotic agents

Medically reviewed by Philip Thornton, DipPharm. Last updated on Aug 23, 2023.

What is Adasuve inhalation?

Adasuve is an antipsychotic medication that affects the actions of chemicals in your brain.

Adasuve inhalation powder is used to treat agitation related to schizophrenia or bipolar disorder.

Adasuve inhalation is given only in a hospital or clinic setting where any breathing problems can be quickly treated.


You should not use Adasuve inhalation if you have breathing problems that can cause bronchospasm (such as asthma or COPD), or if you are currently having trouble breathing with cough and wheezing. You should not use this medicine if you have ever had breathing problems after using it in the past.

Adasuve inhalation can cause bronchospasm (wheezing, chest tightness, shortness of breath) that can lead to serious lung problems or make your breathing stop. This medicine must be given in a hospital or clinic setting where your doctor can quickly treat any serious side effects that occur.

This medicine is not approved for use in older adults with dementia-related psychosis.

Before taking this medicine

You should not be treated with Adasuve if you are allergic to loxapine or amoxapine, or if you have:

Loxapine may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

To make sure Adasuve is safe for you, tell your doctor if you have ever had:

Tell your doctor if you are pregnant or you get pregnant. Using antipsychotic medication during the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn.

You should not breastfeed while using Adasuve.

How is Adasuve given?

Adasuve inhalation is usually given once every 24 hours as needed.

A healthcare provider will give you this medicine in a hospital or clinic setting where you can be quickly treated if any serious side effects occur.

A healthcare provider can teach you how to properly use the Adasuve inhaler device.

The inhaler device has a green indicator light on one side and a pull tab at one end. When the pull tab is released the green light will turn on, showing that the device is ready for use.

Once the green light turns on, you must use the inhaler within 15 minutes or the device will deactivate. Do not try to use the inhaler if the green light is off.

While using the Adasuve inhaler device, you may hear a clicking sound and the device may feel warm. These are normal functions. After you have inhaled your dose, the green light will turn off to show that the entire dose has been used.

You will be watched closely for at least 1 hour after using Adasuve, to make sure you do not have any breathing problems.

Dosing information

Use: For the treatment of schizophrenia. Usual Adult Dose for Agitated State:

10 mg by oral inhalation once within a 24-hour period

-To mitigate the risk of bronchospasm, all patients must undergo screening and examination prior to administration.
-This drug must be administered by a healthcare professional only in an enrolled healthcare facility.

Use: For the acute treatment of agitation associated with schizophrenia or bipolar I disorder

What happens if I miss a dose?

Since Adasuve inhalation is used when needed, you may need only one dose. Adasuve is usually not given more than once in a 24-hour period.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving Adasuve?

Avoid driving or operating machinery until you know how this medicine will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.

Do not drink alcohol. Dangerous side effects could occur.

Adasuve side effects

Get emergency medical help if you have signs of an allergic reaction to Adasuve: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

Common Adasuve side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Adasuve?

Using Adasuve with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

This list is not complete. other drugs may interact with loxapine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Adasuve only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.