What is lumateperone?
Lumateperone is used to treat schizophrenia in adults.
Lumateperone may also be used for purposes not listed in this medication guide.
Lumateperone is not approved for use in older adults with dementia-related psychosis.
People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.
Before taking this medicine
You should not use lumateperone if you are allergic to it.
Lumateperone may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.
Tell your doctor if you have ever had:
Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking lumateperone without your doctor's advice.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lumateperone on the baby.
You should not breastfeed while using lumateperone.
lumateperone may affect fertility (your ability to have children), whether you are a man or a woman.
Lumateperone is not approved for use by anyone younger than 18 years old.
How should I take lumateperone?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take once a day with or with food.
You will need frequent medical tests.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking lumateperone?
While you are taking lumateperone, you may be more sensitive to very hot conditions. Avoid becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise.
Avoid driving or hazardous activity until you know how lumateperone will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Grapefruit may interact with lumateperone and lead to unwanted side effects. Avoid the use of grapefruit products.
Lumateperone side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.
High doses or long-term use of lumateperone can cause a serious movement disorder that may not be reversible. The longer you use lumateperone, the more likely you are to develop this disorder, especially if you are a woman or an older adult.
Lumateperone may cause serious side effects. Call your doctor at once if you have:
feeling unsteady, feeling like you might pass out;
uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
tightness in your neck or throat, trouble swallowing;
trouble breathing or speaking;
high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;
low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing; or
severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
Common side effects of lumateperone may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Lumateperone dosing information
Usual Adult Dose for Schizophrenia:
42 mg orally once a day
-Dose titration is not necessary.
-This drug should be taken with food.
Use: Treatment of schizophrenia
Usual Adult Dose for Bipolar Disorder:
42 mg orally once a day
-Dose titration is not required.
Use: As monotherapy or as adjunctive therapy with lithium or valproate for the treatment of depressive episodes associated with bipolar I or II disorder (bipolar depression).
What other drugs will affect lumateperone?
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Tell your doctor about all your current medicines. Many drugs can affect lumateperone, especially:
an antibiotic, antifungal, or antiviral medicine;
blood pressure medication;
bronchodilator asthma medication;
cold or allergy medicine (Benadryl and others);
medicine to treat depression, anxiety, mood disorders, or mental illness;
medicine to treat overactive bladder;
medicine to treat Parkinson's disease;
seizure medicine; or
This list is not complete and many other drugs may affect lumateperone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
More about lumateperone
- Side effects
- Drug interactions
- Dosage information
- During pregnancy
- Reviews (66)
- En español
- Drug class: atypical antipsychotics
Related treatment guides
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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