Naproxen Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Naproxen	Humira (adalimumab)	Methotrexate	Enter another drug to compare

Naproxen

Humira (adalimumab)

Methotrexate

Prescription and OTC

Naproxen is effective for the short-term relief of pain and inflammation associated with arthritis, gout, menstruation, and tendonitis; however, like other NSAIDs, it has the potential to adversely... View more

Prescription only

Humira is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as Rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more

Prescription only

Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more

More about Naproxen

More about Humira (adalimumab)

More about Methotrexate

Ratings & Reviews

Naproxen has an average rating of 6.8 out of 10 from a total of 683 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 25% reported a negative effect.

Humira has an average rating of 6.4 out of 10 from a total of 703 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 30% reported a negative effect.

Methotrexate has an average rating of 6.5 out of 10 from a total of 338 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 24% reported a negative effect.

View all 683 reviews

View all 703 reviews

View all 338 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Nausea (5.7%)
Upset stomach (5.7%)
Pain (3.5%)
Dizziness (3.1%)
Vomiting (2.3%)
Headaches (2.0%)
Stomach pain (1.9%)

View all Naproxen side effects

Pain (10.7%)
Headaches (4.7%)
Fatigue (4.4%)
Psoriasis (4.4%)
Rash (4.3%)
Tiredness (3.6%)
Itching (3.3%)

View all Humira side effects

Nausea (14.8%)
Tiredness (13.9%)
Fatigue (11.5%)
Hair loss (8.6%)
Pain (6.8%)
Headaches (5.6%)
Loss of appetite (5.0%)

View all Methotrexate side effects

Drug Class

Nonsteroidal anti-inflammatory drugs

Generic Availability

Lower cost generic

N/A

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	4 tablet
Strength	500 mg
Per unit^*	$2.80
Cost^*	$11.19

View all Naproxen prices

Quantity	2 kit
Strength	40 mg/0.8 mL
Per unit^*	$3,700.02
Cost^*	$7,400.03

View all Humira prices

Quantity	20 each
Strength	2.5 mg
Per unit^*	$1.52
Cost^*	$30.31

View all Methotrexate prices

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Dosage Forms

Oral capsule
Oral delayed release tablet
Oral suspension
Oral tablet
Oral tablet, extended release

Subcutaneous kit

Injectable powder for injection
Injectable solution
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

18 hours

480 hours

15 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 459 drugs are known to interact with Naproxen:

99 major drug interactions (437 brand and generic names)
341 moderate drug interactions (1372 brand and generic names)
18 minor drug interactions (128 brand and generic names)

A total of 555 drugs are known to interact with Humira:

300 major drug interactions (871 brand and generic names)
245 moderate drug interactions (944 brand and generic names)
9 minor drug interactions (37 brand and generic names)

A total of 728 drugs are known to interact with Methotrexate:

145 major drug interactions (668 brand and generic names)
567 moderate drug interactions (2745 brand and generic names)
15 minor drug interactions (47 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using naproxen together with alcohol. Do not drink alcohol while taking... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more

Disease Interactions

First Approval Date

March 11, 1976

December 31, 2002

December 07, 1953

WADA Class View classifications

N/A

More Information

Patient Resources

Naproxen uses

Humira uses

Methotrexate uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Naproxen Alternatives Compared

See also:

Humira

Taltz

Cosentyx

Paracetamol

Tylenol

Cymbalta

Oxycodone

Tramadol

Duloxetine

Cyclobenzaprine

Further information

Naproxen Alternatives Compared

See also:

Further information

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