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Naproxen Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Naproxen Simponi Methotrexate
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Naproxen Simponi (golimumab) Methotrexate
Prescription and OTC

Naproxen is effective for the short-term relief of pain and inflammation associated with arthritis, gout, menstruation, and tendonitis; however, like other NSAIDs, it has the potential to adversely... View more

Prescription only

Prescribed for Ankylosing Spondylitis, Rheumatoid Arthritis, Psoriatic Arthritis, Spondyloarthritis, Ulcerative Colitis. Simponi may also be used for purposes not listed in this medication guide.

Prescription only

Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more

More about Naproxen More about Simponi (golimumab) More about Methotrexate
Generic Status

Lower-cost generic is available

No lower-cost generic available

Lower-cost generic is available
Ratings & Reviews

Naproxen has an average rating of 6.8 out of 10 from a total of 672 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 25% reported a negative effect.

Simponi has an average rating of 6.2 out of 10 from a total of 110 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 31% reported a negative effect.

Methotrexate has an average rating of 6.5 out of 10 from a total of 327 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 23% reported a negative effect.

View all 672 reviews

View all 110 reviews

View all 327 reviews

Drug Class
Side Effects

See also: naproxen side effects in more detail.

Common side effects include:

  • infection

See also: Simponi side effects in more detail.

Commonly reported side effects include:

  • increased liver enzymes

See also: methotrexate side effects in more detail.
Pricing and Coupons * Prices are without insurance
Quantity 4 tablet
Dosage 500 mg
Per Unit* $2.67
Cost* $10.69

View all naproxen prices

Quantity 0.5 mL
Dosage 50 mg/0.5 mL
Per Unit* $12,375.84
Cost* $6,187.92

View all Simponi prices

Quantity 20 each
Dosage 2.5 mg
Per Unit* $1.77
Cost* $35.42

View all methotrexate prices

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Dosage Form(s) Available
  • Oral capsule
  • Oral delayed release tablet
  • Oral suspension
  • Oral tablet
  • Oral tablet, extended release
  • Subcutaneous solution
  • Injectable powder for injection
  • Injectable solution
  • Oral tablet
Brand Names
Aflaxen, Aleve, Aleve Back and Muscle Pain, All Day Pain Relief, All Day Relief, Anaprox, Anaprox-DS, Comfort Pac with Naproxen, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan, Naprosyn, Naproxen Sodium DS, Pamprin All Day Relief View more Other golimumab brands include: Simponi Aria Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

18 hours

336 hours

15 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
X
Category X Not for use in pregnancy

See the full pregnancy warnings document.
Drug Interactions

A total of 419 drugs are known to interact with naproxen:

  • 96 major drug interactions (418 brand and generic names)
  • 305 moderate drug interactions (1248 brand and generic names)
  • 18 minor drug interactions (130 brand and generic names)

A total of 455 drugs are known to interact with Simponi:

  • 268 major drug interactions (778 brand and generic names)
  • 180 moderate drug interactions (673 brand and generic names)
  • 7 minor drug interactions (34 brand and generic names)

A total of 668 drugs are known to interact with methotrexate:

  • 133 major drug interactions (626 brand and generic names)
  • 519 moderate drug interactions (2606 brand and generic names)
  • 16 minor drug interactions (51 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using naproxen together with alcohol. Do not drink alcohol while taking... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
  • Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more
Disease Interactions
First Approval Date

March 11, 1976

April 24, 2009

December 07, 1953
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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