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Comparing Aspirin vs Naproxen

Aspirin

Naproxen

Aspirin relieves pain and inflammation and helps to thin the blood. It is used to treat and prevent a wide range of different conditions. Higher dosages are associated with stomach irritation and an... more

Naproxen is effective for the short-term relief of pain and inflammation associated with arthritis, gout, menstruation, and tendonitis; however, like other NSAIDs, it has the potential to adversely... more

Prescription and OTC

Prescription and OTC

Ratings & Reviews

Recent helpful reviews
7.3
33 Reviews

For Back Pain Have tried Motrin, Aleve, Tylenol for back pain and nothing works as well. Take it with food and take a brand that is coated and even the few side effects are lessened. It's still the safest and most effective in my personal view.

10
Renlynn

For Back Pain Asprin is much better,than Advil,Aleve for back pain and pain in joints. It's cheap and effective. The biggest disadvantage for aspirin is gastrointestinal disturbances.

10
cccv2
6.9
478 Reviews

For Period Pain I've suffered from horrible period cramps my entire life. When I was younger, I would need to be picked up from school and was bed ridden all day. Advil has never helped reduce these cramps, in fact, it made my bleeding heavier. I started taking naproxen after my obgyn recommended it and it really does help to reduce the severity of the cramps. I still get mild cramps the first two days, but I am able to function and perform my daily activities. It works more efficiently if you take it twice a day for a few days leading to your period.

8
Chris1119

For Period Pain Girls... If you want to be able to function and actually get out of bed this is the solution for you. I have unbearable cramps to where I'm stuck in bed and cry all day from the pain. I've tried everything over the counter and nothing has worked. I was prescribed the 550 mg and my life has changed. Even though there are times where I still have pain it's not as bad as it was. I don't experience any real side effects except sometimes I get a little tired, but it's not horrible.

8
Anonymous

View all 33 reviews

View all 478 reviews

Drug Class

Side Effects

See the full aspirin side effects document.

See the full naproxen side effects document.

Pricing and Coupons

* Prices are without insurance
Quantity 10 tablet
Dosage 325 mg
Per Unit* $0.44
Cost* $4.44
View all aspirin prices
Quantity 4 tablet
Dosage 500 mg
Per Unit* $2.37
Cost* $9.49
View all naproxen prices

Get free Discount Card

Get free Discount Card

Generic Availability

Yes (this medicine)

Yes (this medicine)

Dosage Form(s) Available
  • Oral delayed release tablet
  • Oral tablet
  • Oral tablet, chewable
  • Rectal suppository
  • Oral capsule
  • Oral delayed release tablet
  • Oral suspension
  • Oral tablet
  • Oral tablet, extended release

Brand Names
Acetylsalicylic Acid, Acuprin 81, Arthritis Foundation Pain Reliever, Arthritis Pain, Ascriptin, Ascriptin Enteric, Ascriptin Maximum Strength, Aspergum, Aspi-Cor, Aspir 81, Aspir-Low, Aspirin Lite Coat, Aspirin Low Strength, Aspiritab, Aspirtab, Bayer Advanced Aspirin, Bayer Aspirin, Bayer Aspirin Extra Strength Plus, Bayer Aspirin Regimen, Bayer Aspirin with Heart Advantage, Bayer Children's Aspirin, Bayer Women's Aspirin With Calcium, Buffasal, Buffered Aspirin, Bufferin, Bufferin Arthritis Strength, Bufferin Extra Strength, Bufferin Low Dose, Buffex, Durlaza, Easprin, Ecotrin, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Ecpirin, Empirin, Entaprin, Entercote, Extra Strength Bayer, Fasprin, Genacote, Gennin-FC, Genprin, Halfprin, Heartline, Litecoat Aspirin, Low Dose ASA, Medi-Seltzer, Migralex, Miniprin, Minitabs, Norwich Aspirin, Sloprin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, St. Joseph 81 mg Chewable Aspirin, St. Joseph Aspirin, Stanback Analgesic, Therapy Bayer, Tri-Buffered Aspirin, YSP Aspirin, Zero-Order Release, ZORprin more... Aflaxen, Aleve, All Day Pain Relief, All Day Relief, Anaprox, Anaprox-DS, Comfort Pac with Naproxen, EC-Naprosyn, Flanax Pain Reliever, Leader Naproxen Sodium, Midol Extended Relief, Naprelan, Naprosyn, Naproxen Sodium DS, Pamprin All Day Relief more...

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

10 hours

18 hours

CSA Schedule**

View glossary of terms.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category
N
Category N Not classified

See the full Pregnancy Warnings document.
C
Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

FDA Alerts

FDA Alerts (2)

FDA Alerts (7)

Drug Interactions

A total of 504 drugs are known to interact with aspirin:

  • 78 major drug interactions (347 brand and generic names)
  • 352 moderate drug interactions (1432 brand and generic names)
  • 74 minor drug interactions (346 brand and generic names)

A total of 511 drugs are known to interact with naproxen:

  • 88 major drug interactions (338 brand and generic names)
  • 365 moderate drug interactions (1339 brand and generic names)
  • 58 minor drug interactions (335 brand and generic names)

Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using aspirin together with alcohol. Do not drink alcohol while taking... more
  • Ask your doctor before using naproxen together with alcohol. Do not drink alcohol while taking... more

Disease Interactions

First Approval Date

June 25, 1965

March 11, 1976

WADA Class

View World Anti-Doping Agency classifications.

N/A

N/A

More Information

Consumer Resources

Professional Resources

Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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