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Medications for Parkinson's Disease

What is Parkinson's Disease:  A progressive, neurological disease first described in 1817 by James Parkinson.

The pathology is not completely understood, but there appears to be consistent changes in the melanin-containing nerve cells in the brainstem

Medications to treat Parkinson's Disease

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
carbidopa / levodopa C N X 21 reviews
6.0

Generic name: carbidopa / levodopa systemic

Brand names:  Sinemet, Sinemet CR, Rytary, Parcopa, Duopa

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Sinemet C N X 6 reviews
7.0

Generic name: carbidopa / levodopa systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Azilect C N 7 reviews
6.0

Generic name: rasagiline systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Mirapex C N X 4 reviews
5.0

Generic name: pramipexole systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
ropinirole C N X 9 reviews
5.0

Generic name: ropinirole systemic

Brand names:  Requip, Requip XL

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Requip C N X 4 reviews
4.0

Generic name: ropinirole systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Sinemet CR C N X 2 reviews
7.0

Generic name: carbidopa / levodopa systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
amantadine C N 8 reviews
7.0

Generic name: amantadine systemic

Brand name:  Gocovri

Drug class: adamantane antivirals, dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
pramipexole C N X 8 reviews
5.0

Generic name: pramipexole systemic

Brand names:  Mirapex, Mirapex ER

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Comtan C N X 5 reviews
4.0

Generic name: entacapone systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Eldepryl C N 1 review
10

Generic name: selegiline systemic

Drug class: monoamine oxidase inhibitors, dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Mirapex ER C N X 2 reviews
8.0

Generic name: pramipexole systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Neupro C N X 12 reviews
6.0

Generic name: rotigotine systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Requip XL C N X 4 reviews
7.0

Generic name: ropinirole systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
selegiline C N 3 reviews
9.0

Generic name: selegiline systemic

Brand names:  Eldepryl, Zelapar

Drug class: monoamine oxidase inhibitors, dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Cogentin N N X Add review
5.0

Generic name: benztropine systemic

Drug class: anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Akineton C N X Add review Rate

Generic name: biperiden systemic

Drug class: anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Artane N N X 3 reviews
3.0

Generic name: trihexyphenidyl systemic

Drug class: anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

 
Stalevo C N X 5 reviews
6.0

Generic name: carbidopa / entacapone / levodopa systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
Apokyn C N X 3 reviews
7.0

Generic name: apomorphine systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Exelon B N 2 reviews
4.0

Generic name: rivastigmine systemic

Drug class: cholinesterase inhibitors

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Rytary C N X 9 reviews
4.0

Generic name: carbidopa / levodopa systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
trihexyphenidyl N N X 5 reviews
3.0

Generic name: trihexyphenidyl systemic

Brand names:  Artane, Trihexane

Drug class: anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
benztropine N N X 1 review
5.0

Generic name: benztropine systemic

Brand name:  Cogentin

Drug class: anticholinergic antiparkinson agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
entacapone C N X 6 reviews
5.0

Generic name: entacapone systemic

Brand name:  Comtan

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
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Topics under Parkinson's Disease

Alternative treatments for Parkinson's Disease

The following products are considered to be alternative treatments or natural remedies for Parkinson's Disease. Their efficacy may not have been scientifically tested to the same degree as the drugs listed in the table above. However there may be historical, cultural or anecdotal evidence linking their use to the treatment of Parkinson's Disease.

Learn more about Parkinson's Disease

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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