Nourianz Side Effects
Generic name: istradefylline
Medically reviewed by Drugs.com. Last updated on July 25, 2020.
Note: This document contains side effect information about istradefylline. Some of the dosage forms listed on this page may not apply to the brand name Nourianz.
For the Consumer
Applies to istradefylline: oral tablet
Side effects requiring immediate medical attention
Along with its needed effects, istradefylline (the active ingredient contained in Nourianz) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking istradefylline:
- Seeing, hearing, or feeling things that are not there
- twitching, twisting, uncontrolled repetitive movements of tongue, lips, face, arms, or legs
- Actions that are out of control
- attack, assault, force
- confusion as to time, place, or person
- delusions of persecution, mistrust, suspiciousness, or combativeness
- dry mouth
- false beliefs that cannot be changed by facts
- increased sexual urges
- irregular heartbeats
- shortness of breath
- talking, feeling, and acting with excitement
- trouble sleeping
- unusual excitement, nervousness, or restlessness
Side effects not requiring immediate medical attention
Some side effects of istradefylline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- Difficulty having a bowel movement (stool)
For Healthcare Professionals
Applies to istradefylline: oral tablet
Across clinical trials, dyskinesia occurred in 15% of patients receiving 20 mg once a day and 17% of patients receiving 40 mg once a day (compared to 8% for placebo); 1% of patients discontinued treatment because of dyskinesia.
Very common (10% or more): Dyskinesia (up to 17%)
Common (1% to 10%): Dizziness
Common (1% to 10%): Constipation, nausea
Common (1% to 10%): Rash
Common (1% to 10%): Decreased appetite, increased blood glucose
Common (1% to 10%): Blood alkaline phosphatase increased
Common (1% to 10%): Upper respiratory tract inflammation
Common (1% to 10%): Blood urea increased
Common (1% to 10%): Hallucinations, abnormal thinking and behavior, insomnia
Rare (less than 0.1%): Impulse control disorder
Postmarketing reports: Increased libido
Across clinical trials, hallucinations occurred in 2% of patients receiving 20 mg once a day and 6% of patients receiving 40 mg once a day (compared to 3% for placebo); 1% of patients discontinued treatment because of hallucinations. Across clinical trials, abnormal thinking and behavior (paranoid ideation, delusions, confusion, mania, disorientation, aggressive behavior, agitation, or delirium) occurred in 1% of patients receiving 20 mg once a day and 2% of patients receiving 40 mg once a day (compared to 1% for placebo). Across clinical trials, 1 patient taking 40 mg/day reported an impulse control disorder. There were no reports in the patients taking 20 mg/day or placebo.
1. "Product Information. Nourianz (istradefylline)." Kyowa Kirin, Inc, Bedminster, NJ.
More about Nourianz (istradefylline)
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Pricing & Coupons
- En Español
- 1 Review
- Drug class: miscellaneous antiparkinson agents
- FDA Approval History
Related treatment guides
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.