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Amantadine

Generic Name: amantadine (a MAN ta deen)
Brand Name: Gocovri, Osmolex ER, Symmetrel

Medically reviewed by Philip Thornton, DipPharm. Last updated on Nov 5, 2020.

What is amantadine?

Amantadine is an antiviral medicine that blocks the actions of viruses in your body.

Amantadine is used to treat Parkinson's disease and "Parkinson-like" symptoms such as stiffness or tremors, shaking, and repetitive uncontrolled muscle movements that may be caused by the use of certain drugs.

Amantadine is also used to treat or prevent influenza A in adults and children. It may not be effective during every flu season because certain strains of the virus may be resistant to amantadine. This medicine should not be used in place of getting a yearly flu shot. The Centers for Disease Control recommends an annual flu shot to help protect you each year from new strains of influenza virus.

Amantadine is available as tablets, capsules, and oral solution.

Important Information

You should not use amantadine if you received a nasal flu vaccine in the past 14 days.

Do not receive a nasal flu vaccine while taking amantadine, and for at least 48 hours after your last dose. You may receive a flu shot (injection) while taking amantadine.

Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this amantadine affects you.

To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.

Heat stroke has happened in people taking amantadine. Be careful in hot weather and during physical activity.

If you have kidney problems, talk with your doctor. Your dose may need to be changed based on how well your kidneys work. Deaths have happened in people with kidney problems whose dose was too high for their kidney function.

Do not stop taking amantadine all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop amantadine, you will want to slowly stop it as ordered by your doctor.

Before taking this medicine

You should not use amantadine if you are allergic to it, or if:

  • you have severe kidney disease; or

  • you received a "live" nasal flu vaccine (FluMist) within the past 14 days.

To make sure amantadine is safe for you, tell your doctor if you have ever had:

  • kidney disease;

  • daytime drowsiness (caused by a sleep disorder or taking certain medicines);

  • congestive heart failure;

  • eczema;

  • glaucoma;

  • liver disease;

  • a seizure;

  • low blood pressure, fainting spells;

  • alcoholism or drug addiction; or

  • mental illness, psychosis, or suicidal thoughts or actions.

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.

It is not known whether amantadine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast-feed while using this medicine.

Amantadine is not approved for influenza in a child younger than 1 year old. Gocovri is not approved for use by anyone younger than 18 years old.

How should I take amantadine?

Take amantadine exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

If you take amantadine to treat influenza A, start taking the medicine within 24 to 48 hours after flu symptoms begin. Keep taking this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared.

You may take amantadine with or without food. You may need to take this medicine only at bedtime. Follow your doctor's instructions.

Measure liquid oral solution carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Swallow the capsule or tablet whole and do not crush, chew, or break it.

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.

Call your doctor if your symptoms do not improve, or if you have a fever with a headache, cough, skin rash, or other new symptoms.

If you take amantadine for Parkinson symptoms: You should not stop using amantadine suddenly or your condition may become worse. Stopping suddenly may also cause unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

Call your doctor if you miss several doses in a row.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amantadine can be fatal.

Overdose symptoms may include confusion, agitation, behavior changes, hallucinations, severe headache or pounding in your ears, muscle stiffness, problems with balance or walking, trouble breathing, fast heartbeats, or seizure.

What should I avoid while taking amantadine?

Do not receive a nasal flu vaccine while using amantadine, and for at least 48 hours after your last dose. The vaccine may not work as well during this time, and may not protect you from influenza. You may receive a flu shot (injection) while taking amantadine.

Do not drink alcohol. Dangerous side effects could occur.

Avoid driving or operating machinery until you know how amantadine will affect you. Amantadine may impair your thinking or reactions. Some people taking this medicine have fallen asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with amantadine can increase your risk of unpleasant side effects.

Amantadine side effects

Get emergency medical help if you have signs of an allergic reaction to amantadine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • extreme drowsiness, falling asleep suddenly even after feeling alert;

  • a light-headed feeling, like you might pass out;

  • shortness of breath (even with mild exertion), swelling in your hands or feet;

  • painful or difficult urination;

  • depression, agitation, aggression, behavior changes, hallucinations, thoughts of hurting yourself;

  • a seizure; or

  • severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.

Side effects may be more likely in older adults.

Common amantadine side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect amantadine?

Using amantadine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interact with amantadine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use amantadine only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Frequently Asked Questions