Amantadine use while Breastfeeding
Drugs containing Amantadine: Symmetrel, Gocovri, Osmolex ER
Amantadine Levels and Effects while Breastfeeding
Summary of Use during Lactation
It is probably best to avoid amantadine during breastfeeding because of its potential negative effect on lactation.
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Amantadine is a dopamine agonist. Clinical studies using amantadine dosages of 100 mg 2 or 3 times daily have demonstrated a decrease in serum prolactin and decreased galactorrhea in patients taking dopaminergic neuroleptic drugs such as phenothiazines, haloperidol and loxapine.[1][2] No studies have been reported on the effects of amantadine on the milk supply in nursing mothers. The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.
References
1. Correa N, Opler LA, Kay SR et al. Amantadine in the treatment of neuroendocrine side effects of neuroleptics. J Clin Psychopharmacol. 1987;7(2):91-5. PMID: 2884239
2. Siever LJ. The effect of amantadine on prolactin levels and galactorrhea on neuroleptic-treated patients. J Clin Psychopharmacol. 1981;1(1):2-7. PMID: 6117579
Amantadine Identification
Substance Name
Amantadine
CAS Registry Number
768-94-5
Drug Class
Antiinfective Agents
Antiparkinson Agents
Antiviral Agents
Dopamine Agents
Administrative Information
LactMed Record Number
434
Last Revision Date
20180402
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about amantadine
- Side Effects
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 27 Reviews – Add your own review/rating
- Drug class: adamantane antivirals
Consumer resources
- Amantadine
- Amantadine Capsules and Tablets
- Amantadine Extended-Release Capsules
- Amantadine Syrup
- Amantadine (Advanced Reading)
Other brands: Symmetrel, Gocovri