Amantadine use while Breastfeeding

Summary of Use during Lactation

It is probably best to avoid amantadine during breastfeeding because of its potential negative effect on lactation.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Amantadine is a dopamine agonist. Clinical studies using amantadine dosages of 100 mg 2 or 3 times daily have demonstrated a decrease in serum prolactin and decreased galactorrhea in patients taking dopaminergic neuroleptic drugs such as phenothiazines, haloperidol and loxapine.[1][2] No studies have been reported on the effects of amantadine on the milk supply in nursing mothers. The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed.

References

1.

Correa N, Opler LA, Kay SR et al. Amantadine in the treatment of neuroendocrine side effects of neuroleptics. J Clin Psychopharmacol. 1987;7(2):91-5. [PubMed: 2884239]

2.

Siever LJ. The effect of amantadine on prolactin levels and galactorrhea on neuroleptic-treated patients. J Clin Psychopharmacol. 1981;1(1):2-7. [PubMed: 6117579]

Substance Name

Amantadine

CAS Registry Number

768-94-5

Drug Class

• Breast Feeding
• Lactation
• Anti-Infective Agents
• Antiparkinson Agents
• Antiviral Agents
• Dopamine Agents