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Amantadine Pregnancy and Breastfeeding Warnings

Amantadine is also known as: Gocovri, Symmetrel

Amantadine Pregnancy Warnings

Amantadine has been assigned to pregnancy category C by the FDA. Some animal studies have revealed evidence of embryotoxicity and teratogenicity using doses 12 times the recommended human dose. There are no controlled data in human pregnancy. A cardiovascular birth defect (single ventricle with pulmonary atresia) was reported in an infant whose mother had taken 100 mg/day during the first 2 weeks of pregnancy. Tetralogy of Fallot and tibial hemimelia was reported in an infant whose mother took 100 mg/day for 1 week during the sixth and seventh week of pregnancy. Amantadine should only be given during pregnancy when benefit outweighs risk.

See references

Amantadine Breastfeeding Warnings

Amantadine is excreted into human milk in small amounts. Due to the potential for adverse effects, the use of amantadine while breastfeeding is not recommended.

See references

References for pregnancy information

  1. Coulson AS "Amantadine and teratogenesis." Lancet 2 (1975): 1044
  2. "Product Information. Symmetrel (amantadine)." DuPont Pharmaceuticals, Wilmington, DE.
  3. Nora JJ, Nora AH, Way GL "Cardiovascular maldevelopment associated with maternal exposure to amantadine." Lancet 2 (1975): 607

References for breastfeeding information

  1. "Product Information. Symmetrel (amantadine)." DuPont Pharmaceuticals, Wilmington, DE.

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