Medically reviewed by Drugs.com. Last updated on Sep 13, 2023.
The recommended dosage of NOURIANZ is 20 mg administered orally once daily. The dosage may be increased to a maximum of 40 mg once daily, based on individual need and tolerability. Initial dose titration is not required.
NOURIANZ can be taken with or without food [see Clinical Pharmacology (12.3)].
Dosage Adjustment with Strong CYP3A4 Inhibitors
The maximum recommended dosage of NOURIANZ with concomitant use of strong CYP3A4 inhibitors is 20 mg once daily [see Drug Interactions (7.1)].
Dosing with Strong CYP3A4 Inducers
Avoid use of NOURIANZ with strong CYP3A4 inducers [see Drug Interactions (7.1)].
Dosage Adjustment in Patients with Hepatic Impairment
The maximum recommended dosage of NOURIANZ in patients with moderate hepatic impairment (Child-Pugh Class B) is 20 mg once daily. Closely monitor patients with moderate hepatic impairment for adverse reactions when on NOURIANZ treatment [see Adverse Reactions (6.1)]. Avoid use of NOURIANZ in patients with severe hepatic impairment (Child-Pugh Class C) [see Use in Specific Populations (8.7)].
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