Carbidopa, entacapone, and levodopa
Medically reviewed: August 30, 2017
What is carbidopa, entacapone, and levodopa?
Levodopa is converted to a chemical called dopamine (DOE pa meen) in the brain. Symptoms of Parkinson's disease may be caused by low levels of dopamine in the brain. Carbidopa helps prevent the breakdown of levodopa before it can reach the brain and take effect. Entacapone increases levels of levodopa in the body.
The combination of carbidopa, entacapone, and levodopa is used to treat Parkinson symptoms such as muscle stiffness, tremors, spasms, and poor muscle control.
Carbidopa, entacapone, and levodopa may also be used for purposes not listed in this medication guide.
You should not take this medication if you are allergic to carbidopa (Lodosyn), entacapone (Comtan), or levodopa (Larodopa), or if you have narrow-angle glaucoma, unusual skin lesions, or a history of skin cancer.
Tell your doctor about all of your medical conditions, especially heart disease, high blood pressure, asthma or other breathing problems, liver or kidney disease, a hormonal disease, an ulcer, glaucoma, or mental illness. Also tell your doctor about all the medications you use.
It may take up to several weeks of using carbidopa, entacapone, and levodopa before your symptoms improve. Talk with your doctor if your symptoms do not improve or if the effects of this medication seem to wear off quickly in between doses.
Do not stop using carbidopa, entacapone, and levodopa without first talking to your doctor.
Before taking this medicine
Do not take this medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.
You should not take this medication if you are allergic to carbidopa (Lodosyn), entacapone (Comtan), or levodopa (Larodopa), or if you have:
unusual skin lesions that have not been checked by a doctor; or
To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:
kidney disease, liver disease, or bile duct obstruction;
an endocrine (hormonal) disease;
a stomach or intestinal ulcer;
depression or other mental illness.
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medication. Talk with your doctor if you believe you have any intense or unusual urges while taking this medicine.
Carbidopa, entacapone, and levodopa may cause hallucinations (the sensation of hearing or seeing something that is not there). Call your doctor if you experience hallucinations.
Some people taking Parkinson's disease medications have developed skin cancer (melanoma). However, people with Parkinson's disease may have a higher risk of melanoma. Talk to your doctor about this risk and what skin symptoms to watch for. You may need to have regular skin exams.
FDA pregnancy category C. It is not known whether carbidopa, entacapone, and levodopa will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Carbidopa, entacapone, and levodopa may pass into breast milk and could harm a nursing baby. You should not breast-feed while you are taking carbidopa, entacapone, and levodopa.
How should I take carbidopa, entacapone, and levodopa?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Take your medicine at regular intervals to keep a steady amount of the drug in your body at all times.
Drink plenty of liquids while you are taking this medication.
It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after a few weeks of treatment. Also tell your doctor if the effects of this medication seem to wear off quickly in between doses.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.
Do not stop using carbidopa, entacapone, and levodopa without first talking to your doctor. You may need to use less and less before you stop the medication completely.
This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using carbidopa, entacapone, and levodopa.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include weakness, loss of coordination, trouble breathing, fainting, or seizure (convulsions).
What should I avoid while taking carbidopa, entacapone, and levodopa?
Carbidopa, entacapone, and levodopa may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Avoid taking iron supplements or eating a diet that is high in protein (protein sources include meat, eggs, and cheese). These things can make it harder for your body to digest and absorb carbidopa, entacapone, and levodopa.
Carbidopa, entacapone, and levodopa side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have a serious side effect such as:
nausea, sweating, feeling like you might pass out (especially when you first start taking this medication);
depression, confusion, hallucinations, unusual thoughts or behavior, thoughts about hurting yourself;
worsening symptoms such as tremors, twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;
severe or ongoing diarrhea, extreme thirst, increased urination, weight loss, leg discomfort, muscle weakness or limp feeling, uneven heart rate;
feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
fast, pounding, or uneven heartbeats;
chest pain or heavy feeling, pain spreading to the arm or shoulder, general ill feeling;
tight feeling in your chest, new or worsening cough, fever, trouble breathing;
easy bruising or bleeding, bloody or tarry stools, coughing up blood;
pain or burning when you urinate; or
unexplained muscle pain, tenderness, or weakness.
Less serious side effects may include:
stomach pain or upset, loss of appetite, constipation;
dry mouth, changes in your sense of taste;
unusual skin changes. mild rash or itching;
muscle cramps, back pain; or
You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
Carbidopa, entacapone, and levodopa dosing information
Usual Adult Dose for Parkinson's Disease:
Switching patients taking separate tablets of entacapone and carbidopa-levodopa: Give corresponding dosage of carbidopa/entacapone/levodopa.
Switching patients not currently taking entacapone who are experiencing the "wearing-off" effect on carbidopa-levodopa therapy: Patients should be first titrated with the individual product of entacapone and the carbidopa-levodopa product (ratio 1:4), and then transferred to a corresponding dosage combination product after symptoms are under control.
The maximum daily dosage of carbidopa/levodopa/entacapone is 8 tablets. Because there is limited experience with total daily doses of carbidopa greater than 300 mg, the maximum recommended daily dose of the carbidopa/entacapone/levodopa 200 tablets is six tablets.
What other drugs will affect carbidopa, entacapone, and levodopa?
Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by carbidopa, entacapone, and levodopa. Tell your doctor if you regularly use any of these other medicines, or any other Parkinson's medications.
Tell your doctor about all other medicines you use, especially:
epinephrine (Epi-Pen, and others);
blood pressure medication;
This list is not complete and other drugs may interact with carbidopa, entacapone, and levodopa. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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