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Generic Name: Levodopa, Carbidopa, and Entacapone (lee voe DOE pa, kar bi DOE pa, & en TA ka pone)
Brand Name: Stalevo

Uses of Stalevo:

  • It is used to treat Parkinson's disease.

What do I need to tell my doctor BEFORE I take Stalevo?

  • If you have an allergy to levodopa, carbidopa, entacapone, or any other part of Stalevo (levodopa, carbidopa, and entacapone).
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Glaucoma, a skin lump or growth, or a history of skin cancer.
  • If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking this medicine within 14 days of those drugs can cause very bad high blood pressure.

This is not a list of all drugs or health problems that interact with Stalevo.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Stalevo?

  • Tell all of your health care providers that you take Stalevo. This includes your doctors, nurses, pharmacists, and dentists.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine affects you.
  • To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take Stalevo.
  • If you have high blood sugar (diabetes), talk with your doctor about which glucose tests are best to use.
  • This medicine may "wear off" as the time for your next dose gets closer. Tell your doctor if this happens and it bothers you.
  • It may take a few months to see the full effect.
  • Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
  • The chance of a type of skin cancer called melanoma may be raised in people with Parkinson's disease. It is not known if this medicine may also raise the chance. Have skin exams while you take Stalevo. Talk with your doctor.
  • If you are 65 or older, use this medicine with care. You could have more side effects.
  • Do not give to a child. Talk with your doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Stalevo while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

How is this medicine (Stalevo) best taken?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food. Take with food if it causes an upset stomach.
  • Swallow whole. Do not chew, break, or crush.
  • Avoid a high protein diet. Keep protein use the same from day to day.
  • Do not take iron products within 2 hours of Stalevo.
  • Do not stop taking this medicine all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop Stalevo (levodopa, carbidopa, and entacapone), you will want to slowly stop it as ordered by your doctor.
  • Take even during sign-free periods.
  • Keep a diary of your signs.
  • Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well.
  • Take Stalevo at the same time of day.
  • To gain the most benefit, do not miss doses.

What do I do if I miss a dose?

  • Take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

See also: Dosage Information (in more detail)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
  • Change in how you act.
  • Hallucinations (seeing or hearing things that are not there).
  • Very bad dizziness or passing out.
  • Feeling confused.
  • A burning, numbness, or tingling feeling that is not normal.
  • Very upset stomach or throwing up.
  • Very loose stools (diarrhea).
  • Throwing up blood or throw up that looks like coffee grounds.
  • Black, tarry, or bloody stools.
  • Very bad belly pain.
  • Muscle pain or weakness.
  • A skin lump or growth.
  • Change in color or size of a mole.
  • Strong urges that are hard to control (such as eating, gambling, sex, or spending money).
  • Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
  • Chest pain or pressure.
  • Shortness of breath.
  • Fever or chills.
  • Sore throat.
  • Any unexplained bruising or bleeding.
  • Some people have fallen asleep during activities like driving, eating, or talking. Some people did not feel sleepy and felt alert right before falling asleep. This has happened up to 1 year after this medicine was started. If you fall asleep during activities, do not drive or do other tasks or actions that call for you to be alert while you take Stalevo. Call your doctor right away if this happens or you feel very sleepy.
  • A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.

What are some other side effects of Stalevo?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Loose stools (diarrhea).
  • Change in color of body fluids to black, brown, or red.
  • Change in taste.
  • Hard stools (constipation).
  • Dizziness.
  • Feeling sleepy.
  • Dry mouth.
  • Headache.
  • Not able to sleep.
  • Not hungry.
  • Upset stomach or throwing up.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

See also: Side effects (in more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Stalevo?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take Stalevo or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Stalevo. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: September 6, 2017

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