Levodopa, Carbidopa, and Entacapone
Generic Name: Levodopa, Carbidopa, and Entacapone (lee voe DOE pa, kar bi DOE pa, & en TA ka pone)
Brand Name: Stalevo
Medically reviewed on July 4, 2018
Uses of Levodopa, Carbidopa, and Entacapone:
- It is used to treat Parkinson's disease.
What do I need to tell my doctor BEFORE I take Levodopa, Carbidopa, and Entacapone?
- If you have an allergy to levodopa, carbidopa, entacapone, or any other part of levodopa, carbidopa, and entacapone.
- If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
- If you have any of these health problems: Glaucoma, a skin lump or growth, or a history of skin cancer.
- If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking levodopa, carbidopa, and entacapone within 14 days of those drugs can cause very bad high blood pressure.
This is not a list of all drugs or health problems that interact with levodopa, carbidopa, and entacapone.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take levodopa, carbidopa, and entacapone with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Levodopa, Carbidopa, and Entacapone?
- Tell all of your health care providers that you take levodopa, carbidopa, and entacapone. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how levodopa, carbidopa, and entacapone affects you.
- To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take levodopa, carbidopa, and entacapone.
- This medicine may "wear off" as the time for your next dose gets closer. Tell your doctor if this happens and it bothers you.
- It may take a few months to see the full effect.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- The chance of a type of skin cancer called melanoma may be raised in people with Parkinson's disease. It is not known if levodopa, carbidopa, and entacapone may also raise the chance. Have skin exams while you take levodopa, carbidopa, and entacapone. Talk with your doctor.
- A dark color (red, brown, or black) may show up in your saliva, urine, or sweat. This is not harmful but may discolor your clothes.
- If you are taking warfarin, talk with your doctor. You may need to have your blood work checked more closely while you are taking it with levodopa, carbidopa, and entacapone.
- If loose stools (diarrhea) or throwing up happens, you will need to make sure to avoid dehydration and electrolyte problems. Talk with the doctor.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using levodopa, carbidopa, and entacapone while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is this medicine (Levodopa, Carbidopa, and Entacapone) best taken?
Use levodopa, carbidopa, and entacapone as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food.
- Swallow whole. Do not chew, break, or crush.
- If you take an iron product or a multivitamin that has iron, ask your doctor or pharmacist how to take it with levodopa, carbidopa, and entacapone. Iron may lower how well your body is able to absorb levodopa, carbidopa, and entacapone.
- Diets high in protein, fat, or calories may lower how well your body absorbs levodopa, carbidopa, and entacapone; tell your doctor if you have a diet like this or if you will be changing your diet. Talk with your doctor.
- Do not stop taking levodopa, carbidopa, and entacapone all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop levodopa, carbidopa, and entacapone, you will want to slowly stop it as ordered by your doctor.
- Take even during sign-free periods.
- Keep a diary of your signs.
- Keep taking levodopa, carbidopa, and entacapone as you have been told by your doctor or other health care provider, even if you feel well.
- Take levodopa, carbidopa, and entacapone at the same time of day.
- To gain the most benefit, do not miss doses.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
See also: Dosage Information (in more detail)
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of low mood (depression), thoughts of killing yourself, nervousness, emotional ups and downs, thinking that is not normal, anxiety, or lack of interest in life.
- Change in how you act.
- Hallucinations (seeing or hearing things that are not there).
- Very bad dizziness or passing out.
- Feeling confused.
- Very upset stomach or throwing up.
- Very loose stools (diarrhea).
- Loose stools (diarrhea) that will not go away.
- Throwing up blood or throw up that looks like coffee grounds.
- Black, tarry, or bloody stools.
- Very bad belly pain.
- Muscle pain or weakness.
- A skin lump or growth.
- Change in color or size of a mole.
- Strong urges that are hard to control (such as eating, gambling, sex, or spending money).
- Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
- Chest pain or pressure.
- Shortness of breath.
- Fever or chills.
- Sore throat.
- Any unexplained bruising or bleeding.
- Some people have fallen asleep during activities like driving, eating, or talking. Some people did not feel sleepy and felt alert right before falling asleep. This has happened up to 1 year after levodopa, carbidopa, and entacapone was started. If you fall asleep during activities, do not drive or do other tasks or actions that call for you to be alert while you take levodopa, carbidopa, and entacapone. Call your doctor right away if this happens or you feel very sleepy.
- A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.
What are some other side effects of Levodopa, Carbidopa, and Entacapone?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Loose stools (diarrhea).
- Hard stools (constipation).
- Feeling sleepy.
- Dry mouth.
- Not able to sleep.
- Upset stomach or throwing up.
- Back pain.
- Belly pain.
- Feeling tired or weak.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
See also: Side effects (in more detail)
If OVERDOSE is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Levodopa, Carbidopa, and Entacapone?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
Consumer information use
- If your symptoms or health problems do not get better or if they become worse, call your doctor.
- Do not share your drugs with others and do not take anyone else's drugs.
- Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
- Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
- Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about levodopa, carbidopa, and entacapone, please talk with your doctor, nurse, pharmacist, or other health care provider.
- If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
More about carbidopa/entacapone/levodopa
- Carbidopa/entacapone/levodopa Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 7 Reviews
- Drug class: dopaminergic antiparkinsonism agents
- Carbidopa, Levodopa and Entacapone (FDA)
- Carbidopa, Levodopa and Entacapone Tablets (FDA)
- Levodopa, Carbidopa, and Entacapone (Wolters Kluwer)