Generic Name: entacapone (en TAK a pone)
Brand Name: Comtan
What is Comtan (entacapone)?
When used with carbidopa and levodopa (Atamet, Parcopa, Sinemet), entacapone increases levels of levodopa in the body.
Entacapone is used together with carbidopa and levodopa to treat "wearing-off" symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control.
Entacapone may also be used for purposes not listed in this medication guide.
What is the most important information I should know about Comtan (entacapone)?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What should I discuss with my healthcare provider before taking Comtan (entacapone)?
You should not use entacapone if you are allergic to it.
To make sure entacapone is safe for you, tell your doctor if you have:
low blood pressure;
liver disease; or
a history of mental illness or psychosis.
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.
People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. You may need to have regular skin exams.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether entacapone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
How should I take Comtan (entacapone)?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Entacapone must be taken together with carbidopa and levodopa. Entacapone used alone will not treat symptoms of Parkinson's disease.
Entacapone can be taken with or without food. Taking the medicine with food may help prevent nausea, which is a common side effect of entacapone.
Drink plenty of liquids while you are taking entacapone.
Entacapone may cause you to fall asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine, which can lead to severely low blood pressure or a serious electrolyte imbalance.
You should not stop using entacapone suddenly. Follow your doctor's instructions about tapering your dose.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include agitation and aggression, or severe drowsiness, confusion, and loss of consciousness.
What should I avoid while taking Comtan (entacapone)?
This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Entacapone may cause you to fall asleep suddenly, even after feeling alert.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Avoid drinking alcohol. It can increase some of the side effects of entacapone.
Comtan (entacapone) side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
agitation, confusion, unusual thoughts or behavior;
hallucinations (hearing or seeing something that is not there);
very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats, tremors, feeling like you might pass out;
severe or ongoing diarrhea;
restless muscle movements in your eyes, tongue, jaw, or neck (or worsening of Parkinson symptoms); or
unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
You may notice that your urine appears orange, red, brown, or black in color. This is not a harmful side effect unless you also have muscle pain and unusual weakness.
Common side effects may include:
nausea, vomiting, stomach pain;
dry mouth; or
uncontrolled muscle movements.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Comtan (entacapone)?
Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking entacapone with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with entacapone, especially:
methylene blue injection;
This list is not complete. Other drugs may interact with entacapone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
More about Comtan (entacapone)
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Images
- Drug Interactions
- Support Group
- Pricing & Coupons
- En Español
- 5 Reviews – Add your own review/rating
- Generic Availability
- Drug class: dopaminergic antiparkinsonism agents
Related treatment guides
Where can I get more information?
- Your pharmacist can provide more information about entacapone.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2012 Cerner Multum, Inc. Version: 5.02.
Date modified: July 24, 2017
Last reviewed: October 26, 2015