Ropinirole Side Effects
Medically reviewed by Drugs.com. Last updated on Jan 3, 2022.
Summary
Commonly reported side effects of ropinirole include: syncope, dizziness, drowsiness, dyskinesia, fatigue, nausea, orthostatic hypotension, viral infection, decreased blood pressure, decreased pulse, and increased pulse. Other side effects include: asthenia, confusion, lower extremity edema, hallucination, hypotension, systolic hypertension, vertigo, and diaphoresis. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to ropinirole: oral tablets
Side effects include:
Patients with early parkinsonian syndrome (without levodopa): Nausea, dizziness, somnolence, syncope, vomiting, fatigue, viral infection, dyspepsia, pain, leg edema, increased sweating, asthenia, dependent edema, orthostatic symptoms, abdominal pain, pharyngitis, abnormal vision, dry mouth, hypertension, confusion, hallucinations, urinary tract infection.
Patients with advanced parkinsonian syndrome (with concomitant levodopa): Dyskinesia, nausea, dizziness, somnolence, headache, hallucinations, falls, abdominal pain, confusion, upper respiratory tract infection, increased sweating, vomiting, arthralgia, tremor, anxiety, urinary tract infection, constipation, pain, hypokinesia, paresthesia, diarrhea, amnesia, nervousness.
Patients with restless legs syndrome: Nausea, somnolence, vomiting, dizziness, fatigue.
For Healthcare Professionals
Applies to ropinirole: oral kit, oral tablet, oral tablet extended release
Gastrointestinal
Very common (10% or more): Nausea (up to 60%), vomiting (up to 12%)
Common (1% to 10%): Dry mouth, abdominal pain, anorexia, dyspepsia, flatulence, constipation, diarrhea, dysphagia, increased saliva, heartburn
Restless Leg Syndrome:
Very common (10% or more): Nausea (up to 40%), vomiting (up to 12.9%)
Common (1% to 10%): Diarrhea, dyspepsia, dry mouth, abdominal pain upper
Uncommon (0.1% to 1%):[Ref]
Nervous system
Parkinson's disease
Very common (10% or more): Dizziness (40%), somnolence (40%), dyskinesia (34%), headache (17%)
Common (1% to 10%): Hyperkinesia, hypesthesia, hypokinesia, paresis, paresthesia, tremor
Uncommon (0.1% to 1%): Sudden onset of sleep, excessive daytime somnolence
Restless Leg Syndrome:
Very common (10% or more): Headache (up to 22.3%), somnolence (12%), dizziness (up to 12.9%)
Common (1% to 10%): Paresthesia, migraine, paradoxical augmentation and rebound of restless leg syndrome[Ref]
Psychiatric
Parkinson's disease
Very common (10% or more): Hallucination (10%)
Common (1% to 10%): Amnesia, impaired concentration, confusion, amnesia, anxiety, abnormal dreaming, nervousness
Uncommon (0.1% to 1%): Psychotic reactions other than hallucinations, included delirium, delusions, paranoia
Frequency not reported: Aggression
Postmarketing reports: Impulse control disorders included pathological gambling and hypersexuality and increased libido
Restless Leg Syndrome:
Common (1% to 10%): Nervousness
Postmarketing reports: Impulse control disorders included pathological gambling and hypersexuality and increased libido[Ref]
Cardiovascular
Parkinson's disease:
Very common (10% or more): Syncope (up to 12%)
Common (1% to 10%): Hypertension, hypotension, orthostatic symptoms, chest pain, dependent edema, leg edema, flushing, extrasystoles, atrial fibrillation, palpitation, tachycardia, peripheral ischemia
Restless Leg Syndrome:
Common (1% to 10%): Syncope
Uncommon (0.1% to 1%): Orthostatic hypotension, peripheral edema
Frequency not reported: Hypotension[Ref]
Immunologic
Common (1% to 10%): Influenza, viral infection[Ref]
General
The most commonly reported adverse reaction reported in patients with early Parkinson's disease included nausea, somnolence, dizziness, syncope, asthenic conditions, viral infection, leg edema, vomiting, and dyspepsia. Among patients with advance Parkinson's disease, the more commonly reported adverse reactions included dyskinesia, somnolence, nausea, dizziness, confusion, hallucinations, sweating, and headache.
The most commonly reported adverse reactions in patients with restless legs syndrome included nausea, vomiting, somnolence, dizziness, and a asthenic condition.[Ref]
Respiratory
Parkinson's disease
Common (1% to 10%): Yawning, upper respiratory tract infection, dyspnea, bronchitis, pharyngitis, rhinitis, sinusitis
Restless Leg Syndrome:
Very common (10% or more): Upper respiratory infection (10.7%)
Common (1% to 10%): Nasopharyngitis, cough, nasal congestion, rhinitis, sinusitis[Ref]
Ocular
Parkinson's disease:
Common (1% to 10%): Eye abnormality, abnormal vision, xerophthalmia, diplopia[Ref]
Metabolic
Parkinson's disease
Common (1% to 10%): Decreased weight[Ref]
Genitourinary
Common (1% to 10%): Impotence, urinary tract infection, pyuria, urinary incontinence, urinary tract infection[Ref]
Other
Parkinson's disease
Very common (10% or more): Asthenic condition (16%)
Common (1% to 10%): Pain, vertigo
Restless Leg Syndrome:
Very common (10% or more): Fatigue (10.4%)
Common (1% to 10%): Asthenic condition, vertigo
Postmarketing reports:[Ref]
Asthenic conditions include asthenia, fatigue, and/or malaise[Ref]
Musculoskeletal
Common (1% to 10%): Arthralgia, arthritis, extremity pain, back pain, injury, myalgia[Ref]
Dermatologic
Common (1% to 10%): Increased sweating[Ref]
Hematologic
Parkinson's disease
Common (1% to 10%): Anemia[Ref]
Hepatic
Parkinson's disease
Common (1% to 10%): Increased alkaline phosphatase
Frequency not reported: Increased liver enzymes[Ref]
Hypersensitivity
Frequency not reported: Hypersensitivity reactions including urticarial, angioedema, rash, pruritus[Ref]
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References
1. "Product Information. Requip (ropinirole)." SmithKline Beecham (2001):
2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
3. Cerner Multum, Inc. "Australian Product Information." O 0
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.