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User Reviews for Horizant

Horizant has an average rating of 7.6 out of 10 from a total of 30 ratings on Drugs.com. 70% of reviewers reported a positive effect, while 19% reported a negative effect.

Condition Avg. Rating Reviews Compare
Restless Legs Syndrome  
7.3
26 reviews 14 medications
Postherpetic Neuralgia  
9.0
4 reviews 41 medications
Summary of Horizant reviews 7.6 30 reviews

Reviews may be edited to correct grammar/spelling, or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published.

Reviews for Horizant

NYCGal November 19, 2011

For Restless Legs Syndrome: “This medicine worked wonders for my restless legs syndrome, and also aches and pains associated with fibromyalgia and moderate low back pain. However, the withdrawal effects are awful (panic, insomnia, paranoia the worst). I even sought a second medical opinion on how to deal with it better and was told to just go back to my usual dose. I was taking 1200mg/day, and ended up tapering down gradually over 7 weeks. One other thing: this medicine interacts with numerous other medicines, so check this for your own situation and make your own informed decision.”

8 / 10
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MP · Taken for 1 to 6 months January 16, 2019

For Restless Legs Syndrome: “My Dr. Switched me to Horizant 600mg. I have been on it for a month. I am not crazy, but Horizant causes insomnia for me. My RLS is under control, however, my brain is wide awake and alert. Has anyone experienced insomnia with Horizant”

1 / 10
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2110081 December 26, 2011

For Restless Legs Syndrome: “Dismal results from other restless legs syndrome medicines, 500 mg Horizant has been a welcome relief. Especially the nausea that always accompanied the other medicines. Noticed relief the first day. While it hasn't completely eliminated the restless legs syndrome issue, I can easily say it has made an 80-90% improvement. Minimal side effects noted slightly itchy skin and occasional watery eyes. PLUS I am sleeping much better”

9 / 10
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Not suffering now July 31, 2013

For Postherpetic Neuralgia: “I suffered with trigeminal neuralgia for over a year before I was diagnosed. They call it "the suicide disease" for a good reason. Such awful pain on the left side of my face, like someone had taken a club and hit me on the side of my head. At times it also felt like a hot poker was lying on my teeth. All I could do was go in a dark, quiet room. Sometimes sound would set it off, but usually it would just happen all by itself. I had tooth fillings taken out, dental X-rays done, trying to find the cause. It's a rare disease. The doctor gave me 600mg Horizant ER samples and I took (1) a day after dinner at 4. It worked! Then they tried to fill my prescription with generic Gabapentin at the pharmacy. No good! Didn't work! Back on Horizant. :)”

10 / 10
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Jenny911 · Taken for 1 to 6 months July 5, 2013

For Restless Legs Syndrome: “So far this medicine has really made the urge to move my legs go away for the entire day with 1 pill. Other medicines I have taken in the past were not as effective and I had to take multiple pills throughout the day.”

9 / 10
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Aquanut · Taken for 1 to 6 months October 17, 2019

For Restless Legs Syndrome: “I was tremendously relieved to see the post from the person who suffered insomnia while on Horizant! I looked up the side effects of this drug and nowhere is could I find insomnia listed as a side effect until I found this person's comment. It is real! I too have been on it for one month and I run full throttle at night and get between 1 and 3 hours of sleep, per Fitbit a night. Last night was a huge breakthrough for me as I took plain Gabapentin instead of this Horizant long acting one. I know it's the same family of drugs but it's not the effect. Go figure but happy I figured this one out.”

1 / 10
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Kvon1977 · Taken for less than 1 month February 21, 2015

For Restless Legs Syndrome: “I have been taking Horizant for about a week now and my RLS has gotten significantly worse. I am up all night walking around, stretching and massaging my legs trying to get them to stop the need to move. This medication has not worked for me and I am hoping to get in contact with my doctor ASAP to change my medication to something that works and not makes it worse.”

1 / 10
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Robert G · Taken for 1 to 6 months July 1, 2019

For Restless Legs Syndrome: “I couldn't stand it anymore: the restless nights was affecting me during the day at work. I tried generic gabapentin taking 3-4 pills with no improvement then Gralise which I couldnt keep track of my dose then Lyrica wasn't helping either! I was about to switch from my family doctor until his nurse practitioner told me about Horizant with only 1 pill at dinner. AMAZING in only about a week I felt so much better, well rested and not tired during the daytime. Thanks for her knowing about newer medications that are indicated for RLS.”

10 / 10
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Lake721 · Taken for 1 to 2 years February 3, 2016

For Restless Legs Syndrome: “I have suffered greatly from RLS for over 20 years. Tried everything and always experienced augmentation. Horizant (although pricey) has been a true life saver. I encourage every suffer of RLS to give this drug a try. It has changed my life”

10 / 10
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Rihanna T. December 11, 2016

For Restless Legs Syndrome: “I currently suffer from severe RLS and experienced severe augmentation with Mirapex. My neurologist prescribed Horizant 600 mg once a day with dinner and within 6 weeks I experienced complete resolution of my augmentation with Mirapex and almost complete resolution of my severe RLS. I make it a goal to never miss a dose. Recently I experienced restless leg syndrome while on a long airplane ride and had taken Horizant the night before. Not sure why this happened other than I was very stressed at the time. I strongly recommend this medication for those with severe RLS. I sleep like a baby at night now after having suffered from RLS for 30+ years. I also use CPAP for severe sleep apnea which has improved my sleep quality immensely.”

10 / 10
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Anonymous · Taken for less than 1 month January 23, 2020

For Restless Legs Syndrome: “I took Horizant 600mg for the first time today and I've been up with RLS all night. I don't know if there is a time frame that it takes for this medication to work but I'm hoping in the next few days it starts to kick in because I'm miserable.”

3 / 10
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Goldengreek · Taken for less than 1 month December 20, 2015

For Restless Legs Syndrome: “I have severe RLS Not only do I have terrible restlessness in my legs back and shoulders, but pains in my legs and back. In the past I took gabapentin and tramadol which barely controlled the symptoms. After taking one pill at 5pm I experienced 100% reduction of my symptoms. This has been a miracle drug for me. It is basically a form of gabapentin which is absorbed and is available in the bloodstream. Brilliant!”

10 / 10
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Coodie · Taken for 1 to 6 months February 19, 2019

For Restless Legs Syndrome: “Horizant is a wonder drug for people suffering with RLS, a non-narcotic medication and it works. I have had RLS since I was a child and the older I got, the worse it got, when I was employed I would be up walking around the house until 3 AM and my alarm would go off at 5:30 AM. My life got to where I dreaded time for sleep because I knew “sleep” was unobtainable. Things got even worse when my legs would go crazy at work and then the RLS migrated to my arms, I thought I would go insane, it was torture, everyday. I took Requip for years and when that stopped working, I consulted a specialist and he prescribed Horizant medication and I am forever grateful to him.”

10 / 10
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KNO · Taken for 1 to 6 months September 2, 2020

For Restless Legs Syndrome: “I have suffered with RLS symptoms for three years. I have always had trouble sleeping, but it has gotten to the point where I barely get any decent sleep. My symptoms confused my family doctor because they presented in my arms and hands, as well. My doctor says in severe cases this can happen. He explained I would need to be on Horizant for 4 to 6 weeks to see the full potential of the medication. However, after one week, almost all of my symptoms were gone. I’m now starting my second bottle and I’m amazed at the difference I can see in my life. I only wish I found this option sooner.”

10 / 10
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axon1093 May 4, 2015

For Restless Legs Syndrome: “This drug is a little strange, because the 600 mg of this is technically "more" than 600 mg of Neurontin (gabapentin) . Also, the medicine starts to be peaks much later than Neurontin (see horizant pharmacokinetics). So, it can be complicated to figure out when to take it. When I take it closer to bed, it seems to work better. However, the instructions which say to take it 6 hours before bed. I noticed a slight improvement over gabapentin (less awakening), but it's not consistent. Also, this drug company is a MESS. My doctor's office staff has been calling for the advertised co-pay discount card since Thanksgiving 2014. It is now May 2015 and he FINALLY got them from the rep (you cannot print them out online)”

6 / 10
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Deedle623 July 25, 2016

For Restless Legs Syndrome: “I had been taking Requip 2 mg. ER for about 3 years. The effects were inconsistent and I was forced to supplement with 1 mg tablet before bed and when I flew or traveled by car. I consulted with the sleep clinic which is certified for restless leg treatment. I was prescribed Horizant 600 mg 1/day and instructed to wean myself from the Requip, .5 mg 3x/day for three days, then two a day for three days then one a day for three days. The first night of Horizant and the reduced Requip was a nightmare of involuntary leg and arm movement, my entire body twisting and turning. However, remainder of my Requip withdrawal and taking the Horizant was a beautiful experience. I slept better than I have in years. My sciatica pain also went away!”

9 / 10
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BarbieRocks · Taken for 1 to 2 years May 26, 2020

For Postherpetic Neuralgia: “After a nearly fatal car accident I have been in PAIN Management ever since. PAIN was controlled, but never able to quiet the damaged nerves. For years I had pain in my L leg from hip to down to my toes, never stops. Pain Management gave me the sample of 600 mg Horizant took away the nerve pain, I had been dealing with for so long. Very expensive, but I did NOT get same result from Lyrica or Gabapentin. Horizant is time-released. I did develop a rash/itch. Above I read, someone was cutting the pill in half? Not recommended as it is time released. That could be dangerous. Side effect most bothersome, confusion, distraction, forgetfulness (I would also comment there is a 300 mg. dose) which they recommend to start with. Pain Management can work with you on "samples" and certain Pharmacy that can give you HUGE discount. I would highly recommend this, for me it was really like a "miracle". Can cost upwards of $900-over $1000”

8 / 10
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Anonymous · Taken for 6 months to 1 year November 29, 2019

For Restless Legs Syndrome: “After a sleep-study, I was diagnosed and classified as "disabled" with chronic insomnia and RLS in 1987. Klonopin has been the only (partial) help for the insomnia. HORIZANT has helped a bit w/the RLS, but it's _obscenely_ expensive.”

5 / 10
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Borzoibabe May 1, 2021

For Restless Legs Syndrome: “I took every RLS drug and patch out there for years, developed augmentation and had to stop so I tried this drug and I thought it didn’t work at all. Then I went to Medical Marijuana and it was great but very expensive and I couldn’t take it on any trips outside of my state so I was very motivated to find something else for vacations. Tried Horizant again and wow, slept all night in a drugged woozy fog with crazy dreams that seems so real they were more like hallucinations but the great news is absolutely no restless leg. My restless leg is so severe that I shred sheets. I have injured my neck and back and it looks like I’m having a seizure my RLS is so bad. So I am grateful to find a medication that finally works. I am going to use Horizant in the short term because I am afraid of the effects of gabapentin because I have taken it before for fibromyalgia and it has affected my memory. I think it will be a great short term drug for me.”

9 / 10
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Nicki · Taken for 1 to 6 months August 15, 2019

For Restless Legs Syndrome: “I’ve been taking Horizant for two months now, and It’s a good medication for restless legs. However, I’ve noticed that my immediate response level to any event has lower a little. Just hit a parking sign because I was not concentrating as usual. Happened very suddenly.”

6 / 10
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Flitzer · Taken for less than 1 month June 20, 2017

For Restless Legs Syndrome: “5 years of SEVERE RLS...maximum 2 hours sleep per night. Deadly afraid of ALL pharmaceuticals, but agreed to try Horizant, in desperation. Took 600 mg at 5 P.M., with no effect. Added 300 mg at 10 P.M., and no effect on the leg motion. Did experience difficulty urinating, headaches unstable standing and walking, and dry eyes. Besides not working (for me), it is VERY expensive. Hate to think of what my doctor will try next.”

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Linda January 23, 2020

For Restless Legs Syndrome: “I am very thankful to read all your opinions. RLS has been my nightmare for more than 40 years, the last 20 finally an acknowledged syndrome with some treatment, the first 25 not being believed or understood, pacing the floor, sleeping on carpeting where I could move my legs against the roughness. I've tried several meds, and am eager to try this. My sister also has RLS with similar symptoms, some success with different meds. Thank you all!”

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Asmec May 9, 2017

For Postherpetic Neuralgia: “I have Nerve pain from shingles (postherpetic Neuralgia)The side effects of this medication were terrible for me. I gained 15 pounds in 1 month, am so extremely tired that I can't function during the day, and my blood pressure had dropped significantly. I was on blood pressure medication and had to stop it. My blood pressure range is now 78/54 to 87/60. I am awaiting for a call back from my physician today. The fatigue is terrible. I decided that I will suffer with the pain and titration off of this drug (I have only been on it for 1 month). The side effects are too devastating.”

8 / 10
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Mally Wally April 23, 2017

For Restless Legs Syndrome: “My sleep study showed I was being awaken over 100 times a night w both muscle twitches and full body jerks. I started w a full tablet of Horizant for an awful night of wakeful jerking around. Horribly hung over next morning and then basically all day-- on sofa-- in stupor. I had heard through the grapevine that there was a period of hardship before your body got used to it. But I am a publisher and needed my wits about me so I halved the dose. Was able to sleep much better. So I halved the dose again. Continued cutting dose until I'm now taking 100 mg a night. Sleeping better than I have in years. I take it between dinner and bed. It is very powerful. I shuffle to bed in a stupor. May start taking it at bedtime--skip passing out.”

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Koch · Taken for 1 to 2 years February 19, 2021

For Postherpetic Neuralgia: “Since I had my bilateral groin hernia, I have been using Horizon for nerve pain. Was the only medicine works for me. I have to stop using for 2 months because was so expensive . My co-payment was $300.00 . My dr found this pharmacy in CT that sell me for $20 per month prescription . My insurance pays and they give me for only $20 a month. I take the 300 mg because the 600mg is too strong for me.”

10 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.