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Medications for Restless Legs Syndrome

Other names: Ekbom Disease; RLS; Willis-Ekbom Disease

What is Restless Legs Syndrome:  Restless legs syndrome is a movement disorder that causes uncomfortable sensations in the legs. These sensations typically are worse during periods of rest, especially just before sleeping at night, but they may happen during daytime periods of inactivity.

Medications to treat Restless Legs Syndrome

The following list of medications are in some way related to, or used in the treatment of this condition.

Drug name Rx / OTC Pregnancy CSA Alcohol Reviews Rating Popularity
Requip Rx C N X 82 reviews
6.0

Generic name: ropinirole systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
ropinirole Rx C N X 178 reviews
6.0

Generic name: ropinirole systemic

Brand name:  Requip

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
Mirapex Rx C N X 78 reviews
8.0

Generic name: pramipexole systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
pramipexole Rx C N X 121 reviews
7.0

Generic name: pramipexole systemic

Brand name:  Mirapex

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

 
gabapentin Off Label Rx C N X 60 reviews
7.0

Generic name: gabapentin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
clonazepam Off Label Rx D 4 X 44 reviews
8.0

Generic name: clonazepam systemic

Drug class: benzodiazepines, benzodiazepine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Neupro Rx C N X 26 reviews
8.0

Generic name: rotigotine systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: AHFS DI Monograph, Prescribing Information

 
Sinemet Off Label Rx C N X 12 reviews
7.0

Generic name: carbidopa / levodopa systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
tramadol Off Label Rx C 4 X 86 reviews
8.0

Generic name: tramadol systemic

Drug class: narcotic analgesics

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
carbidopa / levodopa Off Label Rx C N X 21 reviews
8.0

Generic name: carbidopa / levodopa systemic

Brand names:  Sinemet, Sinemet CR, Parcopa

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Horizant Rx C N X 16 reviews
7.0

Generic name: gabapentin enacarbil systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

 
clonidine Off Label Rx C N X 3 reviews
7.0

Generic name: clonidine systemic

Drug class: antiadrenergic agents, centrally acting

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
gabapentin enacarbil Rx C N X 17 reviews
7.0

Generic name: gabapentin enacarbil systemic

Brand name:  Horizant

Drug class: gamma-aminobutyric acid analogs

For consumers: interactions, side effects

For professionals: A-Z Drug Facts

 
rotigotine Rx C N X 26 reviews
8.0

Generic name: rotigotine systemic

Brand name:  Neupro

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

 
pregabalin Off Label Rx C 5 X 4 reviews
9.0

Generic name: pregabalin systemic

Drug class: gamma-aminobutyric acid analogs

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph

Off Label: Yes

 
Sinemet CR Off Label Rx C N X 1 review
8.0

Generic name: carbidopa / levodopa systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
lamotrigine Off Label Rx C N X 1 review
1.0

Generic name: lamotrigine systemic

Drug class: triazine anticonvulsants

For consumers: dosage, interactions, side effects

For professionals: A-Z Drug Facts, AHFS DI Monograph, Prescribing Information

Off Label: Yes

 
Parcopa Off Label Rx C N X Add review Add

Generic name: carbidopa / levodopa systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: dosage, interactions, side effects

For professionals: Prescribing Information

Off Label: Yes

 
levodopa Rx N N X 1 review
8.0

Generic name: levodopa systemic

Drug class: dopaminergic antiparkinsonism agents

For consumers: interactions, side effects

 

Topics under Restless Legs Syndrome

Learn more about Restless Legs Syndrome

Legend

Off Label This medication may not be approved by the FDA for the treatment of this condition.
Prescription Only / Over the Counter
Rx Prescription Only
OTC Over the Counter
Rx/OTC Prescription or Over the Counter
Pregnancy
A Adequate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).
B Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.
X Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.
N FDA has not classified the drug.
Controlled Substances Act Schedule
N Is not subject to the Controlled Substances Act.
1 Has a high potential for abuse. Has no currently accepted medical use in treatment in the United States. There is a lack of accepted safety for use under medical supervision.
2 Has a high potential for abuse. Has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions. Abuse may lead to severe psychological or physical dependence.
3 Has a potential for abuse less than those in schedules 1 and 2. Has a currently accepted medical use in treatment in the United States. Abuse may lead to moderate or low physical dependence or high psychological dependence.
4 Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
5 Has a low potential for abuse relative to those in schedule 4. Has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 4.
Alcohol
X Interacts with Alcohol.

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