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User Reviews for Pregabalin to treat Restless Legs Syndrome

Also known as: Lyrica, Lyrica CR

Pregabalin has an average rating of 7.0 out of 10 from a total of 8 ratings for the treatment of Restless Legs Syndrome. 63% of users who reviewed this medication reported a positive effect, while 25% reported a negative effect.

Pregabalin Rating Summary

7.0/10 average rating

8 ratings from 5 user reviews.

Compare all 28 medications used in the treatment of Restless Legs Syndrome.

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Zelder · Taken for 1 to 6 months April 6, 2020

“I was prescribed pregablin for RLS and noticed straight away a positive reaction but it then quickly returned back to normal. Going up the doses doesn't seem to be making a huge difference, on 75mg I've had RLS at least twice a day for a week now. I haven't had any side affects and it hasn't affected my sleep in any way with my RLS waking me up a few times.”

2 / 10
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Anonymous · Taken for 2 to 5 years March 10, 2020

“I take pregabalin 75mg for almost two years for my spinal stenosis but did not help in my right leg tingling. There are side effect caused by this medication such as sleeplessness, weight gain, speech slurs, and memory loss. I do not recommend to use it.”

2 / 10
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cozyjohn · Taken for 1 to 6 months March 10, 2020

“Over the past 15 year's I have been dealing with a constant feeling of day time sleepiness. Tried meds to help me sleep, which made it worse. Did 5 different sleep studies, because everyone said that I had sleep apnea. But that was not the case. Did a brain scan which was normal. Thank God. Finally was working with a sleep doctor who said that I had idiopathic hypersomnolence. Which means that doctor's have no idea what's going on, but recognize that something is. Treated with stimulants, all which worked but not very long. Finally last year began seeing a specialist in hypersomnia. Almost immediately he tested and said that I had restless leg syndrome. It's not enough to cause pain, but it almost wakes me up constantly all night. Began various treatments, but none worked. But started taking Lyrica two months ago, so far remarkable results. Don't give up......”

9 / 10
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microSuSu February 7, 2010

Lyrica (pregabalin): “I have tried a number of different drugs for RLS, including Lyrica, Mirapex, Klonopin, Neurontin, and clonidine. Lyrica and Mirapex are by far the most effective medicines for me in treating restless legs syndrome. Note: I am confined to a special type of power wheelchair. My primary diagnosis is Ehlers-Danlos Syndrome; other diagnoses of particular note include Chronic Pain Syndrome, idiopathic polyneuropathy, Schizoaffective Bipolar Disorder, CHF, seizure disorder, severe degenerative bone & joint disease, severe degenerative disk disease, obstructive sleep apnea, GERD; among others. I have a colostomy and a suprapubic catheter.”

9 / 10
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Anonymous · Taken for 1 to 6 months November 28, 2019

“Having tried 2 meds for RLS, Mirapex (which worked very well but led me to compulsive behaviours) and Neurontin (which had disappointing results), I was desperate to find a long acting medication that would help alleviate my RLS symptoms throughout the day and night. I was started on a low dose of 75 mg and gradually increased to 375 mg. Initially, I felt very encouraged by my response even though it took at least 5 or 6 days to have an effect on my RLS. By the time I had increased to 150 mg, I was sleeping much better and had no RLS during the day. Unfortunately, it appears that I am experiencing diminishing effect with my higher dosage and need to increase yet again with the unwanted fogginess I feel all morning. I wake up during the night with RLS and it last for at least 1 to 2 hours before I can fall asleep again. I am not RLS free.”

6 / 10
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Benzy3 · Taken for 1 to 6 months February 8, 2017

“It took a couple of days but it did stop my restless legs. The downside is that in the few weeks I was taking it, I put on about a stone in weight. It's good for making you sleepy. I now use tramadol and am trialling trazodone.”

8 / 10
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Fedup6813 August 31, 2016

“Have been on neurotin severe side effects legs on fire never helped rls was also on new med called horizant severe reaction both which landed me in the hospital. Placed on lyrics no more rls way less diabetes foot pain. Finally after many nights of pure hell I feel human please note taking to much WILL cause you to black out. Please take as directed. Don't plan on driving until you see how it effects you! Thank you lyrics finally some sleep and relief. Oh very expensive so I pray those who need it can afford it and or the copay! Happy dreams! ”

10 / 10
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Frequently asked questions

joycerob January 29, 2010

Lyrica (pregabalin): “Was prescribed Lyrica for fibromyalgia. Since starting it 2 yrs ago, I haven't had RLS! What a nice bonus!!”

10 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Learn more about Restless Legs Syndrome

IBM Watson Micromedex

Symptoms and treatments

Mayo Clinic Reference