Pregabalin for Restless Legs Syndrome User Reviews

Brand names: Lyrica, Lyrica CR

Pregabalin has an average rating of 6.9 out of 10 from a total of 15 reviews for the off-label treatment of Restless Legs Syndrome. 53% of reviewers reported a positive experience, while 20% reported a negative experience.

Filter by condition

Pregabalin rating summary

6.9/10 average rating

15 ratings from 15 user reviews.

Compare all 22 medications used in the treatment of Restless Legs Syndrome.

10		20%
9		20%
8		13%
7		13%
6		7%
5		7%
4		0%
3		0%
2		13%
1		7%

Reviews for Pregabalin

cozyj...
Taken for 1 to 6 months
March 10, 2020

"Over the past 15 year's I have been dealing with a constant feeling of day time sleepiness. Tried meds to help me sleep, which made it worse. Did 5 different sleep studies, because everyone said that I had sleep apnea. But that was not the case. Did a brain scan which was normal. Thank God. Finally was working with a sleep doctor who said that I had idiopathic hypersomnolence. Which means that doctor's have no idea what's going on, but recognize that something is. Treated with stimulants, all which worked but not very long. Finally last year began seeing a specialist in hypersomnia. Almost immediately he tested and said that I had restless leg syndrome. It's not enough to cause pain, but it almost wakes me up constantly all night. Began various treatments, but none worked. But started taking Lyrica two months ago, so far remarkable results. Don't give up......"

9 / 10

Was this helpful?Yes No

53 Report

Anonymous
Taken for 1 to 6 months
November 28, 2019

"Having tried 2 meds for RLS, Mirapex (which worked very well but led me to compulsive behaviours) and Neurontin (which had disappointing results), I was desperate to find a long acting medication that would help alleviate my RLS symptoms throughout the day and night. I was started on a low dose of 75 mg and gradually increased to 375 mg. Initially, I felt very encouraged by my response even though it took at least 5 or 6 days to have an effect on my RLS. By the time I had increased to 150 mg, I was sleeping much better and had no RLS during the day. Unfortunately, it appears that I am experiencing diminishing effect with my higher dosage and need to increase yet again with the unwanted fogginess I feel all morning. I wake up during the night with RLS and it last for at least 1 to 2 hours before I can fall asleep again. I am not RLS free."

6 / 10

Was this helpful?Yes No

25 Report

Movin...
February 4, 2022

"I’ve had RLS for 22 years. Last year I finally talked to my doctor and she put me on Requip. It did NOTHING but make me sleepy the next day. So we tried Lyrica and it is a game changer. I’m on 300mg a day and it works fantastic. No RLS and I can sleep finally. BUT I am so groggy during the day. I wish I could find a doctor who believed in a low dose opiate (not tramadol because I’m an epileptic) but until I do, Lyrica will remain my go to for this awful condition!"

7 / 10

Was this helpful?Yes No

13 Report

Frequently asked questions

micro...
February 7, 2010

Lyrica (pregabalin) "I have tried a number of different drugs for RLS, including Lyrica, Mirapex, Klonopin, Neurontin, and clonidine. Lyrica and Mirapex are by far the most effective medicines for me in treating restless legs syndrome. Note: I am confined to a special type of power wheelchair. My primary diagnosis is Ehlers-Danlos Syndrome; other diagnoses of particular note include Chronic Pain Syndrome, idiopathic polyneuropathy, Schizoaffective Bipolar Disorder, CHF, seizure disorder, severe degenerative bone & joint disease, severe degenerative disk disease, obstructive sleep apnea, GERD; among others. I have a colostomy and a suprapubic catheter."

9 / 10

Was this helpful?Yes No

48 Report

Nancy...
Taken for 1 to 6 months
February 21, 2024

"I started out on Ropinirole on which I quickly maxed out; my MD had me wean off the Ropinirole slowly while starting on Lyrica 350 mg. At first, the memory problems and frequent double vision were horrible. 3 months later I’m doing great!"

10 / 10

Was this helpful?Yes No

2 Report

Are you taking this medicine?

Anonymous
Taken for 5 to 10 years
June 5, 2022

"I am on pregabalin 600mg p/d for GAD and restless legs, it works well for restless leg syndrome, works 99% of the time, theres every once in a blue moon where it doesn't help for 1 day but most of the time I'd say its a great option, I'd give it a 9/10 for restless legs"

9 / 10

Was this helpful?Yes No

9 Report

Anonymous
Taken for 2 to 5 years
March 10, 2020

"I take pregabalin 75mg for almost two years for my spinal stenosis but did not help in my right leg tingling. There are side effect caused by this medication such as sleeplessness, weight gain, speech slurs, and memory loss. I do not recommend to use it."

2 / 10

Was this helpful?Yes No

12 Report

More FAQ

Fedup
August 31, 2016

"Have been on neurotin severe side effects legs on fire never helped rls was also on new med called horizant severe reaction both which landed me in the hospital. Placed on lyrics no more rls way less diabetes foot pain. Finally after many nights of pure hell I feel human please note taking to much WILL cause you to black out. Please take as directed. Don't plan on driving until you see how it effects you! Thank you lyrics finally some sleep and relief. Oh very expensive so I pray those who need it can afford it and or the copay! Happy dreams! "

10 / 10

Was this helpful?Yes No

18 Report

Benzy
Taken for 1 to 6 months
February 8, 2017

"It took a couple of days but it did stop my restless legs. The downside is that in the few weeks I was taking it, I put on about a stone in weight. It's good for making you sleepy. I now use tramadol and am trialling trazodone."

8 / 10

Was this helpful?Yes No

17 Report

Judy...
Taken for 2 to 5 years
January 5, 2022

"I’ve been taking Lyrica 75mg for quite sometime but it’s for my back/bones problems. Been affected with RLS for years, finally a sleep doctor recommended me taking it a bit earlier in the evening and with a womens multi vitamin. I think it’s working a bit better but I was considering having him up the dose just a bit to see if it rids me of this horrible condition. Good luck to all of you jumpy legged people! Lol"

7 / 10

Was this helpful?Yes No

5 Report

Zelder
Taken for 1 to 6 months
April 6, 2020

"I was prescribed pregablin for RLS and noticed straight away a positive reaction but it then quickly returned back to normal. Going up the doses doesn't seem to be making a huge difference, on 75mg I've had RLS at least twice a day for a week now. I haven't had any side affects and it hasn't affected my sleep in any way with my RLS waking me up a few times."

2 / 10

Was this helpful?Yes No

7 Report

easto...
Taken for less than 1 month
June 19, 2022

"Methadone for 27 years for RLS, it has been wonderful. No side-effects that I have noticed. Insurance and Kaiser-Permanente is forcing me to withdraw from methadone and replace it with pregabalin, so I have been taking methadone and pregabalin at the same time; decreasing methadone while increasing pregabalin (currently 75mg). This has been just one week so I cannot give a fair evaluation, except I am sleepy all day with some dizziness."

5 / 10

Was this helpful?Yes No

3 Report

Bunky...
Taken for 6 months to 1 year
April 9, 2023

Lyrica (pregabalin) "I started with Lyrica for what is either RLS or PLMD. At the same time I was also having increasing sciatic problems. My sciatic problems were immediately substantially reduced as were my leg movement problems. However now displeased with some of the side effects taking only 100mg. Will try and lower dosage hoping to keep up the pros and lessen the cons."

8 / 10

Was this helpful?Yes No

1 Report

joyce...
January 29, 2010

Lyrica (pregabalin) "Was prescribed Lyrica for fibromyalgia. Since starting it 2 yrs ago, I haven't had RLS! What a nice bonus!!"

10 / 10

Was this helpful?Yes No

47 Report

Heather
Taken for less than 1 month
October 4, 2021

"No good. Did not help at all. Up all night and the side effects scare me !! Not worth the risk."

1 / 10

Was this helpful?Yes No

9 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.