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User Reviews for Pramipexole

Also known as: Mirapex, Mirapex ER

Pramipexole has an average rating of 6.8 out of 10 from a total of 195 ratings on Drugs.com. 59% of those users who reviewed Pramipexole reported a positive effect, while 26% reported a negative effect.

Condition Avg. Rating Reviews Compare
Restless Legs Syndrome  
6.9
173 reviews 14 medications
Parkinson's Disease  
5.0
14 reviews 55 medications
Periodic Limb Movement Disorder  
7.6
8 reviews 9 medications
Summary of Pramipexole reviews 6.8 195 reviews

Reviews may be moderated or edited before publication to correct grammar and spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest in the medication will not be published. As reviews and ratings are subjective and self-reported, this information should not be used as the basis for any statistical analysis or scientific studies.

Reviews for Pramipexole

Cliff February 21, 2021

For Restless Legs Syndrome: “I tried a variety of non-drug options and herbal supplements, but my RLS continued to get worse. First prescription was neurontin. After the third day, I was extremely groggy and almost unable to function. Dr then put me on pramipexole at the lowest dose, and my RLS symptoms went away almost immediately. Over the years I have had to increase my dosage. Eventually, it was upped to one 1mg tablet at bedtime, which has been very effective until about 6 months ago. I've noticed that if I take the pill just one hour later than the night before, my legs start up. If I take it within 3 hours, it usually works quickly. But this month I've started having problems during the day, so it may be time for another dose adjustment. I also have irreversible peripheral neuropathy from taking Thalidomide as part of a drug study 25 years ago, so not sure about that impact on my RLS (which started after the neuropathy). Only negative side effect is compulsive behavior around gambling.”

9 / 10
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KZ · Taken for 6 months to 1 year February 13, 2021

Mirapex (pramipexole) for Restless Legs Syndrome: “My RLS came out of nowhere in 2/2020. It was bothering me 24/7. I was constantly kicking people. No one wanted to sit next to me. It was embarassing. By 6/2020, I had had enough! So I saw a neurologist who started me on Mirapex. After a month or so, he would increase the dose. At one time I was taking .25mg, 3 of them, 3 times a day. It really helped me. I now take 2 tablets twice a day. It still bothers me slightly when I get in bed, but once I'm asleep, I'm fine. I have been eating more sweets than usual and put on a little weight. Don't know if this is the Mirapex or the fact that I stopped drinking.”

9 / 10
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sickofdrs February 11, 2021

For Restless Legs Syndrome: “I have been taking Sifrol for 4 months for RLS caused by another med I'm on. It certainly worked. I've just weaned off it after speaking to a pharmacist (don't they often know way more than doctors by the way?) who said I could try magnesium tablets/day for RLS as he had many patients who had success with this. Thinking it would not work I tried it and to my amazement it worked the very first night. I realise everyone is different and it may or may not work for you. I'm experiencing severe withdrawals from Sifrol, the most disturbing is insomnia, I'm getting about 2 hours sleep a night. Also foggy headed, ANGRY and dizzy, headaches. For goodness sake GPs please please please don't just stick us on meds when you haven't done your research on less harmful things that may help. Yes, I'm angry......but grateful to have found that pharmacist. Once these withdrawals are over I'll be even more grateful.”

4 / 10
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JDevilsmile May 11, 2020

Mirapex (pramipexole) for Restless Legs Syndrome: “I have been on Mirapex for 4 years. It is very effective but I am sleepy during the day. Started at .125 mg and I’m currently taking .25 to .5 mg per day. There is a tendency for me to build up a tolerance so every so often I have to go off the medication just so my body will reset to a lower dose. I have tried to go off this drug and it was horrible. I couldn’t do it. My recommendation is do not try this drug unless your RLS is severe.”

7 / 10
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JimM February 12, 2019

Mirapex (pramipexole) for Restless Legs Syndrome: “I have had RLS all my life. After trying several medications my mother in law read an article in one of the senior magazines talking about RLS and using a Parkinson medication for treatment of RLS...I talked to my doctor and he prescribed it and it was wonderful, finally able to get some sleep. But then it happened...Keep in mind I never stepped footing in a Casino, I was careful with my money but a few years into my treatment once my dosage had increased to about 1mg I went to a Casino and tried a slot machine and from that point on I was hooked, I have lost so much money going to Casinos, it has made my life so sad and depressing, no one actual believes you, the medication has this hideous addiction side effect. You struggle day after day with this addiction and other addictions as well, overeating and increased sexual urge. I tried several times to get off Mirapex but it is impossible I couldn't sleep for over 5 days and the symptoms of RLS were 10x's worse. ”

10 / 10
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SWS Canadian · Taken for 10 years or more March 27, 2013

Mirapex (pramipexole) for Restless Legs Syndrome: “I was diagnosed with Restless Legs Syndrome back in the '90's. I was first prescribed levodopa/carbidopa and it was wonderful at first. However it started losing effectiveness and making me sick during the day at times. Then a new medicine came out- Mirapex and I was put on it at 0.25mg before bedtime. It worked well for several years but had to be upped to 0.5mg. I found that Mirapex controlled my RLS fairly well and I was on it for 12 years! The last year I forced myself to cut back to 0.25mg again and put up with some symptoms. Then, I recently stopped taking it altogether. I have been taking strong vitamin supplements, but they didn't stop the RLS. However, when I started taking Magnesium, Potassium, and Calcium, and bathing in bath salts the RLS has disappeared.”

9 / 10
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elga August 27, 2016

Mirapex (pramipexole) for Restless Legs Syndrome: “I have been taking Mirapex for over 8 years now at .125 mg up to 4 times a day; however, I usually take two at 6 in the evening, and another one an hour before bedtime, and it does a wonderful job. I began on Requip and was on it for almost a year and half, but it just stopped having any effect, and that is when I began Mirapex. I have severe RLS, and before Mirapex, I was close to losing my mind from sleep deprivation and the consequent stress and anxiety. This medicine has literally kept me from suicide. I have had absolutely no negative side effects.”

10 / 10
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Kate · Taken for 1 to 6 months July 30, 2020

Mirapex (pramipexole) for Restless Legs Syndrome: “I've suffered from RLS for 30 years, and have tried almost everything to relieve it. My new doctor prescribed Mirapex, and it has been amazing. The only side effect has been a bit of daytime drowsiness, but I reduced the dosage a bit, and it's gotten better. And I'll take a short period of daytime drowsiness over the horrible RLS I was experiencing every night!”

10 / 10
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Rip Van Winkle · Taken for 2 to 5 years July 15, 2014

Mirapex (pramipexole) for Restless Legs Syndrome: “I was diagnosed with Restless Legs Syndrome about 4 yrs ago and was prescribed Mirapex. My symptoms were so bad I wouldn't sleep for days and was non functioning due to being sleep deprived. The doctor put me on 0.25mg every evening but my RLS was creeping into daylight hours, so I was prescribed 0.25mg twice a day. That did the trick and it has saved my sanity. I no longer have any symptoms of RLS --and as a side note - I have no side effects either from the medicine.”

10 / 10
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Paul Nolan February 3, 2017

Mirapex (pramipexole) for Restless Legs Syndrome: “My wife has suffered from RLS for 8 years. Mirapex is the only drug she has been prescribed that allow her a full nights sleep. We've worked and are working on alternative treatments using supplements/exercise but so far all we've been able to do is drop her dose from 3 to 1 tablet every evening. Side effects nearly destroyed our 25 year marriage. Compulsive behavior in shopping/gambling/cheating over the last 3 years. Be very careful with this drug, be honest with your family/friends and you can deal with it. I wonder how many of the users on here actually have compulsive behavior caused by this drug but don't realize it ?”

5 / 10
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PatJab40 January 31, 2018

Mirapex (pramipexole) for Restless Legs Syndrome: “I am 77 years old. My father suffered (I am sure) with RLS undiagnosed and was prescribed sedatives. Mine began in my late forties and for years I just didn't sleep more than two or three hours a night until I happened to tell a friend who also suffered from RLS. She was taking Mirapex and gave me three of hers. I took one the first night and it was a miracle. I began taking .025 dosage. Eventually, I was upped to .050, then .075, the dosage I'm on now. It works, for sure, and I can't imagine life without it, but my eating is out of control. It's a compulsion for me. If I fast, I'm okay, but as soon as I eat, I can't stop. During the day, I find myself snacking when I know I'm not really hungry, and at night I eat a full plate of food and could easily eat another. Later I can't believe what I ate, how much I ate, or the fact that I never felt full or at least embarrassed that I ate more than anyone else. Does anyone else have this problem?”

8 / 10
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snowdiva · Taken for 5 to 10 years August 6, 2017

Mirapex (pramipexole) for Restless Legs Syndrome: “I have had restless leg syndrome for over twenty years. I have taken a lot of different medications to try to stop the horrible feeling that having RLS gives you.My father had it and so does my brother. I not only have it in my legs but it can also affect my arms. Its a real good time when it hits me in all my limbs at the same time. One day my brother told me about Mirapex. I got the medication from my doctor after having RLS every night for a week. I don't know what I would do without it. It worked from the first time I took it. All I can say is....who ever invented Mirapex, THANK YOU SO VERY MUCH.”

10 / 10
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George March 3, 2020

For Restless Legs Syndrome: “I started taking pramipexole 8 years ago. .75 mg ER late morning and .5 mg non ER 1 hour before bed. It worked well until I realized my compulsive shopping was due to a side effect. The shopping started when the daily dose was doubled from .375 to .75. I kept making excuses for the packages arriving each day but my significant other kept pointing out that receiving six packages a day was not normal. (I have no idea why I suddenly need a linen closet full of throw blankets I don’t use, enough chapstick for the entire town, and every subscription box available.) As soon as my doctor found out, he decreased the daily dose back to .375 and put me on Horizant. Oh my...the RLS is worse than it has ever been and I am still shopping online. I am hoping this will be short lived and after a few weeks my body will forget all about this drug. Now I fear side effects from Horizant which is gabapentin enacarbil. I wish I had known compulsive behavior was a side effect of pramipexole.”

3 / 10
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Darlinpowell514 February 1, 2018

Mirapex (pramipexole) for Restless Legs Syndrome: “Absolutely AVOID this medication. I lost my job as a correctional officer, committed a 1st degree felony, used drugs, lied to my spouse, all for gambling. This medication was prescribed to treat my horrible case of restless legs..and it altered all my rational decision making, made me feel like doing things I KNOW BETTER NOT TO (changed Impulse control/compulsive behaviors). I have a severe gambling problem. Do NOT take this. ....”

3 / 10
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kitty September 26, 2019

Mirapex (pramipexole) for Restless Legs Syndrome: “Mirapex is the only medication that completely controls my RLS. It's like it doesn't exist. Unfortunitly, I can't take it. My side effect is to suddenly fall asleep and fall. I have been black and blue from the falls. I've fallen off chairs, while standing and any place else.”

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cabo · Taken for 5 to 10 years October 20, 2019

For Restless Legs Syndrome: “I have been taking Pramipexole for about 7 years and find I am increasing the dosage to get the desired result more and more. Some day's I take 2 mg but split the pills and take some in the am and some pm. The side effects are getting much worse with the increased dose and I can feel my body needing the pill my wife calls the crazy pill! My RLS is so bad it even comes during the day mostly while driving. The worst thing I hate is the intense urge to fall asleep while driving and the insomnia at night. I sleep four hours per night and that is poor quality sleep. I tried all the other drugs for RLS and none worked so I feel doomed to take this poison till I die. Seems they can put a man on the moon and take the heart out of one person and put it in another but can't stop RLS and that irritates me greatly! I would not suggest any one take this med unless it is the last resort ! I feel for every one of you with RLS for I have had cancer three times and feel the RLS is worse!”

6 / 10
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Joy January 17, 2020

Mirapex (pramipexole) for Restless Legs Syndrome: “I've had RLS for years.. it was destroying my life. I was put on Sinemet which worked for 3 years, then I couldn't even stay in bed as I was having to do excercises in the middle of the night to stop the RLS do the sleep deprivation was really hard on me and was taking it's toll on my family. My Mother swore that Mirapex was a miracle for her, so I got it and took 2 at bedtime. It was worse than ever!! I was so lethargic and weak, I could hardly stand to attempt to stop my legs. I seriously would never take this medication again.”

1 / 10
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Sandy Morris · Taken for 1 to 6 months September 30, 2017

Mirapex (pramipexole) for Restless Legs Syndrome: “I only suffer from RLS at night. I took carpidopa levodopa for about 1 year and then it was no longer enough. My Dr told me to try Requip. I took one pill and had the worst headache ever even the next morning and my jaw and teeth hurt horribly. I read reviews on Mirapex and ask my Dr if I could try it. I've been on it for 3 months with no side effects and can rest all night with zero movement. Before, my husband said I would run all night in bed. Mirapex is a wonderful drug for RLS. I'm so thankful I discovered it!”

10 / 10
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MsQ · Taken for 10 years or more January 5, 2020

For Restless Legs Syndrome: “I have taken pramipexole for decades. I was unaware of any side effects until I read the other reviews. One possible side effect: I may enjoy shopping too much. Also, my prescribed dosage has increased steadily through the years. I currently take 1.5 mg. at bedtime. As it is not the extended release variety, and if I am already suffering, I chew the pill. Sometimes, I have to take additional measures to stop the torment. A hot shower may help, a nocturnal walk around the yard, or to sleep someplace where I usually don't sleep. Sometimes I get no relief at all. I can't get my comments to be submitted. What a waste of my time.”

9 / 10
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I have had RLS since childhood · Taken for 5 to 10 years June 21, 2016

Mirapex (pramipexole) for Restless Legs Syndrome: “I have had RLS since childhood. I was on Requip and Gabepentin and the RLS was relieved for a short time and then returned with a vengence. My Mother, brothers and sister and grandmother also have it. I was finally put on Mirapex ER starting at .25 about 6 years ago and am presently on 3.75 mg once a day. This medication is the only one that pretty much controls the RLS. I have had no side effects. Interesting that they say only use immediate release for RLS. I have been on extended release for 6 years. I don't know what I will do if this medication stops working as I now have symptoms in my arms and hands. I am now 67 y/o. :”

10 / 10
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Nightmareday&night · Taken for 10 years or more December 25, 2016

Mirapex (pramipexole) for Restless Legs Syndrome: “At first was a godsend. 20 years later, whole body dystonia, haven't slept in 5 nights.I thought this the best and now I believe it will kill me. Not being dramatic. I am getting old and my body is giving out trying to handle getting off this drug. I worked in the addiction industry and never saw this much suffering and pain”

1 / 10
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glauderback · Taken for 5 to 10 years November 29, 2012

Mirapex (pramipexole) for Restless Legs Syndrome: “Restless legs syndrome is a hard problem to deal with. Mirapex seems like a God send. But like most things it comes with a cost. First was the dollar cost which over the last 6 years has gone up considerably. The next price you pay is from side effects. Falling asleep while talking to someone is embarrassing and dangerous. But I've found a wonderful fix. While at the doctors I had to use a Doctor's Assistant (who was playing on her cell phone while talking to me). She gave me a prescription for Mirapex that is time released and you only take it at night just before bed time. My energy level has increased 10x and I don't fall asleep while dinning out with my wife. Blessed by Doctor%u2019s Assistant and her playing on the cell phone actually was searching on the intranet for something to help with the problem.”

10 / 10
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Status · Taken for 1 to 6 months May 29, 2020

For Restless Legs Syndrome: “Completely knocks out my RLS like a charm. My RLS had been getting worse due to my SSRI treatment so my doctor prescribed Pramipexole in a relatively small 0.125 mg dose when needed before bedtime. “When needed” is a tough decision because, from what I’ve read, the drug could take up to 3 hours to kick in. But, for me, I have normally found relief in less than an hour. The problem is that I feel like a zombie the next day. Drowsy, cloudy head, sluggish for most of the day after taking it. I’ve started breaking the tablets in half to take down the dosage even more. It still works but the side effects are still there. I’m currently searching for another path towards RLS relief with a different medication.”

7 / 10
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Weezer1964 · Taken for 10 years or more September 29, 2015

Mirapex (pramipexole) for Restless Legs Syndrome: “Mirapex is a great medication for RLS. I started taking it when it first came out. I was a little stuffy if for some reason I didn't fall asleep right away but I didn't notice any other side affects, which is why I'm commenting now. I am one of the lucky (sarcasm) ones who had severe side affects, incontrollable compulsive behavior. Gambling consumed my mind and almost ruined my life. I went to my doctor for help, he sent me to a psychiatrist and tested me for drugs but apparently had no knowledge of the side affects. Even the psychiatrist, who specialized in gambling addiction, had no knowledge of the Mirapex side affects. The people at gamblers anonymous didn't know about it, really, no one does and I'd like to change that.”

9 / 10
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Paboda · Taken for 1 to 2 years June 16, 2016

Mirapex (pramipexole) for Restless Legs Syndrome: “It does work, but the side effects can be damaging. After a year of being on the medication I became a compulsive gambler ( one of the side effects). I became suicidal at one point. Spent some time in a hospital, where we discovered the root of my problem was mirapex.”

3 / 10
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Lucky September 23, 2019

Mirapex (pramipexole) for Restless Legs Syndrome: “Doctor recommended this after trying gabapentin (in which gabapentin was very helpful just made me extremely tired throughout the day). First day I took it, hit me like a train. I could tell my body was getting uneasy so I quickly got myself ready for bed because I wasn’t sure what I was in for. The second I laid in bed. Extreme nausea and dizziness I was waiting for my food to come right back up that I had just eaten. My body was just taking a toll I had to call into work the next day because I still felt sick when I woke up. Then after reading other reviews I decided that was the last time I would ever take that pill again.”

1 / 10
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kitty90 March 18, 2016

Mirapex (pramipexole) for Restless Legs Syndrome: “Have been suffering with rls for 10 yrs., at least. Tried Requip, neurontin, quinine, nothing worked. Started Mirapex 3 weeks ago. No more rls! I cant believe it. My life was hell. Even helps during the day. I started on .5 mg at 6pm. Daily. This has been a miracle for me, no side effects.”

10 / 10
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sumuji · Taken for 1 to 6 months June 13, 2013

Mirapex (pramipexole) for Restless Legs Syndrome: “It takes care of the Restless Legs Syndrome symptoms but also seems to give me insomnia, which kind of defeats the purpose. I can initially go to sleep and get a 3-4 hours but then I'm suddenly wide awake. Requip worked for a while but you have to increase dosage fairly quickly and that causes some bad side effects. I may have to try a 3rd option.”

7 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.