Skip to Content

Pramipexole Patient Tips

Medically reviewed on Nov 27, 2017 by C. Fookes, BPharm.

How it works

  • Pramipexole may be used in the treatment or some movement disorders such as restless legs syndrome (RLS) and Parkinson's Disease (PD). Pramipexole binds to dopamine receptors and mimics the actions of dopamine, a naturally occurring neurotransmitter.
  • Dopamine is known to be reduced or absent in the brains of people with Parkinson's disease (PD), and this lack of dopamine is thought to cause many of the symptoms associated with PD. By stimulating the same receptor sites as dopamine, pramipexole helps to restore dopamine activity in the brain, reducing the symptoms of PD.
  • Experts aren't sure exactly how pramipexole works in the treatment of restless legs syndrome (RLS).
  • Pramipexole belongs to the class of medicines known as dopamine agonists.


  • May help relieve symptoms of (Parkinson's Disease) PD such as stiffness, tremors, muscle spasms and poor muscle control.
  • Immediate-release pramipexole may help treat moderate-to-severe Restless Legs Syndrome (RLS). Extended-release tablets are not indicated for RLS.
  • May be used alone or in conjunction with levodopa to treat PD symptoms.
  • Available as immediate-release and extended-release tablets.
  • Generic pramipexole is available.


If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Drowsiness, including falling asleep spontaneously. Nausea, dizziness, insomnia, constipation, asthenia (lack of energy) are also commonly reported side effects.
  • Significant orthostatic hypotension (a rapid drop in blood pressure causing dizziness when going from a lying or sitting down position to a standing position) is also common.
  • Hallucinations, psychotic behaviors, rhabdomyolysis (serious muscle destruction), retinal deterioration and vision loss, edema, sexual dysfunction and dyskinesias (involuntary muscle movements such as tics) have also been reported with pramipexole.
  • Pramipexole has been associated with intense urges to gamble, have sex, spend money recklessly, or overeat. Some of these urges may resolve with dosage reduction.
  • The dosage or pramipexole may need reducing in people with kidney disease. pramipexole is not usually given to women who are pregnant or breastfeeding and is not recommended for use in people under the age of 18 years.
  • Alcohol may enhance the sedative and dizziness side effects of pramipexole.
  • Pramipexole use has been associated with an increased risk of melanoma skin cancer in people with Parkinson's disease. Experts are not sure if this is a direct cause of the disease or the medications used to treat it.
  • May interact with some medicines including those that also affect dopamine (such as phenothiazines or metoclopramide).

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.

Bottom Line

Pramipexole is a dopamine agonist (mimics the effects of the neurotransmitter dopamine) that may be used in the treatment of Parkinson's disease and Restless Legs Syndrome. It may cause spontaneous sedation and psychotic-like side effects.


  • Take exactly as prescribed by your doctor. Do not double your dose if you miss a dose.
  • May be taken with or without food. Taking with food may help reduce the risk of gastrointestinal side effects, such as nausea.
  • Do not crush, break or chew extended-release pramipexole tablets.
  • Do not take extended-release pramipexole and immediate-release pramipexole tablets at the same time.
  • Pramipexole needs to be started at a low dose and the dosage increased slowly to reduce the risk of large drops in blood pressure (more likely to occur during pramipexole initiation). When you are getting up from a lying down or sitting position, do so slowly. Pramipexole may make you dizzy and more likely to fall.
  • Tell your doctor if your symptoms get worse while taking pramipexole.
  • Pramipexole may impair your thinking or reactions and make driving or operating machinery dangerous. Do not drive or perform hazardous tasks until you know how pramipexole affects you. In some people, pramipexole may cause a sudden onset of sleep, even during the daytime.
  • Do not drink alcohol while taking pramipexole.
  • Pramipexole may cause withdrawal symptoms if stopped suddenly. Follow your doctor's instructions if pramipexole needs to be discontinued.
  • Tell the person's doctor if you notice that a person taking pramipexole experiencing hallucinations, psychotic symptoms, or any out-of-character behaviors such as an increased need to gamble, have sex, or spend money.
  • Be aware that people with PD have a 2 to 6-fold higher risk of melanoma than people without PD. Experts aren't sure if this is due to the disease or medications used to treat the disease. Check your skin frequently for melanomas, and see a dermatologist yearly if you are taking pramipexole for any reason.
  • Keep your tablets away from moisture, heat, and light.

Response and Effectiveness

  • Pramipexole is rapidly absorbed and peak concentrations are reached within two hours. Food does not affect the extent of pramipexole absorption, although it may delay how fast it reaches its peak.


Pramipexole [Package Insert]. Revised 06/2017. Zydus Pharmaceuticals (USA) Inc.

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use pramipexole only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that this information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This drug information does not endorse drugs, diagnose patients or recommend therapy. It is an informational resource designed as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of this information. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2017 Revision Date: 2017-11-27 02:08:04