Gocovri Dosage

Generic name: AMANTADINE 68.5mg
Dosage form: capsule, coated pellets
Drug class: Dopaminergic antiparkinsonism agents

Medically reviewed by Drugs.com. Last updated on Oct 10, 2024.

Dosing Information

The initial daily dosage of GOCOVRI is 137 mg, administered orally once daily at bedtime. After one week, increase to the recommended dosage of 274 mg (two 137 mg capsules) once daily at bedtime. GOCOVRI is not interchangeable with other amantadine immediate- or extended-release products.

Administration Information

GOCOVRI should be swallowed whole. Do not crush, chew or divide capsules. If needed, GOCOVRI may be administered by carefully opening and sprinkling the entire contents on a small amount (teaspoonful) of soft food, such as applesauce. The drug/food mixture should be swallowed immediately without chewing. Do not store mixture for future use.

GOCOVRI can be taken with or without food.

Concomitant use of GOCOVRI with alcohol is not recommended.

It is recommended to avoid sudden discontinuation of GOCOVRI.

Dosing in Patients with Renal Impairment

The initial and maximum recommended daily dosage of GOCOVRI for patients with renal impairment (creatinine clearance estimated by Modification of Diet in Renal Disease (MDRD) method) is provided below.

1Increase, if needed, after one week of the initial dosage
Creatinine Clearance	Dosage
Mild renal impairment (60 to 89 mL/min/1.73 m 2)	Initial dosage: 137 mg once daily at bedtime. After one week, increase to recommended dosage of 274 mg once daily at bedtime.
Moderate renal impairment (30 to 59 mL/min/1.73 m 2)	Initial dosage: 68.5 mg once daily at bedtime Maximum recommended dosage: 137 mg once daily at bedtime 1
Severe renal impairment (15 to 29 mL/min/1.73 m 2)	68.5 mg once daily at bedtime
End Stage Renal Disease (below 15 mL/min/1.73 m 2)	Contraindicated

Discontinuation and Missed Dose

Rapid dose reduction or withdrawal of GOCOVRI may cause adverse reactions. Therefore, to discontinue GOCOVRI in patients who have been on the drug for more than 4 weeks, GOCOVRI dosage should, if possible, be reduced by half for the final week of dosing.

If a dose of GOCOVRI is missed, the next dose should be taken as scheduled.