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Motrin Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Motrin Cimzia Methotrexate
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Motrin (ibuprofen) Cimzia (certolizumab) Methotrexate
Prescription and OTC

Prescribed for Back Pain, Chronic Myofascial Pain, Aseptic Necrosis, Gout - Acute, Juvenile Rheumatoid Arthritis, Costochondritis, Headache, Diffuse Idiopathic Skeletal Hyperostosis, Dysautonomia... View more

Prescription only

Prescribed for Ankylosing Spondylitis, Crohn's Disease, Crohn's Disease - Active, Crohn's Disease - Maintenance, Non-Radiographic Axial Spondyloarthritis, Plaque Psoriasis, Psoriasis, Psoriatic... View more

Prescription only

Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more

Related suggestions
More about (ibuprofen) More about Cimzia (certolizumab) More about Methotrexate
Ratings & Reviews

Motrin has an average rating of 8.5 out of 10 from a total of 16 ratings on Drugs.com. 71% of reviewers reported a positive effect, while 7% reported a negative effect.

Cimzia has an average rating of 6.7 out of 10 from a total of 90 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 21% reported a negative effect.

Methotrexate has an average rating of 6.6 out of 10 from a total of 334 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect.

View all 16 reviews

View all 90 reviews

View all 334 reviews

Drug Class
Side Effects

See also: Motrin side effects in more detail.

See also: Cimzia side effects in more detail.

See also: methotrexate side effects in more detail.
Generic Availability
Lower cost generic approved

N/A

Lower cost generic
Pricing and Coupons * Prices are without insurance

We could not find an exact match for this medicine. Try searching the Price Guide directly.

We could not find an exact match for this medicine. Try searching the Price Guide directly.
Quantity 20 each
Dosage 2.5 mg
Per Unit* $1.77
Cost* $35.42

View all methotrexate prices

Get free Discount Card

Get free Discount Card

Get free Discount Card

Dosage Forms Available

N/A
  • Subcutaneous kit
  • Injectable powder for injection
  • Injectable solution
  • Oral tablet
Brand Names
Other ibuprofen brands include: A-G Profen, Actiprofen, Addaprin, Advil, Advil Children's, Advil Film-Coated, Advil Infant's Concentrated Drops, Advil Junior Strength, Advil Liqui-Gels, Advil Migraine, Caldolor, Cap-Profen, Children's ElixSure IB, Children's Motrin, Childrens Ibuprofen Berry, Genpril, Help I Have An Aching Body, IBU-200, Midol IB, Midol Maximum Strength Cramp Formula, Motrin Childrens, Motrin IB, Motrin Infant Drops, Motrin Junior Strength, Motrin Migraine Pain, Motrin Pediatric, NeoProfen, Nuprin, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Proprinal View more

N/A

 Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

4 hours

336 hours

15 hours
CSA Schedule ** View glossary of terms
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
N
Not a controlled drug

Is not subject to the Controlled Substances Act.
Pregnancy Category
C
Category C Risk cannot be ruled out

Prior To 30 Weeks Gestation

D
Category D Positive evidence of risk

Starting At 30 Weeks Gestation

See the full pregnancy warnings document.
B
Category B No proven risk in humans

See the full pregnancy warnings document.
X
Category X Not for use in pregnancy

See the full pregnancy warnings document.
Drug Interactions

A total of 397 drugs are known to interact with Motrin:

  • 97 major drug interactions (429 brand and generic names)
  • 285 moderate drug interactions (1105 brand and generic names)
  • 15 minor drug interactions (80 brand and generic names)

A total of 480 drugs are known to interact with Cimzia:

  • 292 major drug interactions (850 brand and generic names)
  • 181 moderate drug interactions (668 brand and generic names)
  • 7 minor drug interactions (34 brand and generic names)

A total of 694 drugs are known to interact with methotrexate:

  • 139 major drug interactions (649 brand and generic names)
  • 539 moderate drug interactions (2654 brand and generic names)
  • 16 minor drug interactions (51 brand and generic names)
Alcohol/Food/Lifestyle Interactions
  • Ask your doctor before using ibuprofen together with alcohol. Do not drink alcohol while taking... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
  • Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
  • Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more
Disease Interactions
First Approval Date

N/A

April 22, 2008

December 07, 1953
WADA Class View World Anti-Doping Agency classifications.

N/A

N/A

N/A
More Information
Patient resources

N/A
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

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