Ibuprofen Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Ibuprofen	Humira (adalimumab)	Methotrexate	Enter another drug to compare

Ibuprofen

Humira (adalimumab)

Methotrexate

Prescription and OTC

Ibuprofen is effective for the short-term relief of minor aches and pains and also reduces inflammation. The risk of stomach-related side effects is about half that seen with aspirin although the... View more

Prescription only

Humira is a TNF-alfa inhibitor that may be used to treat a wide range of different inflammatory conditions, such as Rheumatoid Arthritis, psoriasis, ankylosing spondylitis, Crohn's disease, and... View more

Prescription only

Methotrexate may be considered for the treatment of psoriasis, rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), mycosis fungoides, and certain cancers, such as ALL or... View more

More about Ibuprofen

More about Humira (adalimumab)

More about Methotrexate

Ratings & Reviews

Ibuprofen has an average rating of 7.3 out of 10 from a total of 242 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 19% reported a negative effect.

Humira has an average rating of 6.4 out of 10 from a total of 703 ratings on Drugs.com. 55% of reviewers reported a positive effect, while 30% reported a negative effect.

Methotrexate has an average rating of 6.5 out of 10 from a total of 339 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 24% reported a negative effect.

View all 242 reviews

View all 703 reviews

View all 339 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Upset stomach (4.5%)
Nausea (4.1%)
Diarrhea (2.5%)
Stomach pain (2.5%)
Vomiting (2.5%)
Allergic reaction (1.2%)
Headaches (1.2%)

View all Ibuprofen side effects

Pain (10.7%)
Headaches (4.7%)
Fatigue (4.4%)
Psoriasis (4.4%)
Rash (4.3%)
Tiredness (3.6%)
Itching (3.3%)

View all Humira side effects

Nausea (14.7%)
Tiredness (13.9%)
Fatigue (11.8%)
Hair loss (8.6%)
Pain (6.8%)
Headaches (5.6%)
Loss of appetite (5.0%)

View all Methotrexate side effects

Drug Class

Nonsteroidal anti-inflammatory drugs

Generic Availability

Lower cost generic

N/A

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	6 tablet
Strength	800 mg
Per unit^*	$1.85
Cost^*	$11.11

View all Ibuprofen prices

Quantity	2 kit
Strength	40 mg/0.8 mL
Per unit^*	$3,700.02
Cost^*	$7,400.03

View all Humira prices

Quantity	20 each
Strength	2.5 mg
Per unit^*	$1.52
Cost^*	$30.31

View all Methotrexate prices

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Dosage Forms

Intravenous solution
Oral capsule
Oral suspension
Oral tablet
Oral tablet, chewable

Subcutaneous kit

Injectable powder for injection
Injectable solution
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

4 hours

480 hours

15 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

Prior To 30 Weeks Gestation

Category D Positive evidence of risk

Starting At 30 Weeks Gestation

See the full pregnancy warnings document.

Category B No proven risk in humans

See the full pregnancy warnings document.

Category X Not for use in pregnancy

See the full pregnancy warnings document.

Drug Interactions

A total of 422 drugs are known to interact with Ibuprofen:

101 major drug interactions (448 brand and generic names)
306 moderate drug interactions (1174 brand and generic names)
15 minor drug interactions (78 brand and generic names)

A total of 556 drugs are known to interact with Humira:

302 major drug interactions (877 brand and generic names)
245 moderate drug interactions (946 brand and generic names)
9 minor drug interactions (37 brand and generic names)

A total of 731 drugs are known to interact with Methotrexate:

148 major drug interactions (678 brand and generic names)
568 moderate drug interactions (2752 brand and generic names)
15 minor drug interactions (47 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using ibuprofen together with alcohol. Do not drink alcohol while taking... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are... View more
Methotrexate may cause liver problems, and using it with other medications that can also affect the... View more

Disease Interactions

First Approval Date

September 19, 1974

December 31, 2002

December 07, 1953

WADA Class View classifications

N/A

More Information

Patient Resources

Humira uses

Methotrexate uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Ibuprofen Alternatives Compared

See also:

Qulipta

Ubrelvy

Cosentyx

Nurtec ODT

Humira

Paracetamol

Tylenol

Cymbalta

Naproxen

Oxycodone

Further information

Ibuprofen Alternatives Compared

See also:

Further information

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