Ibuprofen Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Ibuprofen	Ubrelvy (ubrogepant)	Nurtec ODT (rimegepant)	Enter another drug to compare

Ibuprofen

Ubrelvy (ubrogepant)

Nurtec ODT (rimegepant)

Prescription and OTC

Ibuprofen is effective for the short-term relief of minor aches and pains and also reduces inflammation. The risk of stomach-related side effects is about half that seen with aspirin although the... View more

Prescription only

Ubrelvy is a prescription medicine that may be used to treat acute migraine attacks in adults and works by blocking the effects of a protein, called CGRP that is thought to play a role in migraine... View more

Prescription only

Nurtec ODT may be placed onto or under the tongue to treat the symptoms of migraine in adults, and it may also be used to prevent episodic migraine when taken every second day. Nurtec ODT works by... View more

More about Ibuprofen

More about Ubrelvy (ubrogepant)

More about Nurtec ODT (rimegepant)

Ratings & Reviews

Ibuprofen has an average rating of 7.3 out of 10 from a total of 241 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 19% reported a negative effect.

Ubrelvy has an average rating of 6.4 out of 10 from a total of 266 ratings on Drugs.com. 59% of reviewers reported a positive effect, while 35% reported a negative effect.

Nurtec ODT has an average rating of 6.4 out of 10 from a total of 327 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 30% reported a negative effect.

View all 241 reviews

View all 266 reviews

View all 327 reviews

Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Upset stomach (4.6%)
Nausea (4.1%)
Diarrhea (2.5%)
Stomach pain (2.5%)
Vomiting (2.5%)
Allergic reaction (1.2%)
Headaches (1.2%)

View all Ibuprofen side effects

Nausea (17.3%)
Dizziness (7.1%)
Tiredness (7.1%)
Drowsiness (5.6%)
Vomiting (5.3%)
Headaches (4.5%)
Sleepy (4.1%)

View all Ubrelvy side effects

Nausea (18.3%)
Dizziness (4.3%)
Headaches (4.0%)
Tiredness (4.0%)
Migraine (3.4%)
Vomiting (3.1%)
Brain fog (2.8%)

View all Nurtec ODT side effects

Drug Class

Nonsteroidal anti-inflammatory drugs

CGRP inhibitors

CGRP inhibitors

Generic Availability

Lower cost generic

No lower cost generic approved

Pricing and Coupons * Prices are without insurance

Quantity	6 tablet
Strength	800 mg
Per unit^*	$1.85
Cost^*	$11.11

View all Ibuprofen prices

Quantity	10 tablet
Strength	100 mg
Per unit^*	$116.81
Cost^*	$1,168.10

View all Ubrelvy prices

Quantity	8 tablet, disintegrating
Strength	75 mg
Per unit^*	$138.56
Cost^*	$1,108.47

View all Nurtec ODT prices

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Dosage Forms

Intravenous solution
Oral capsule
Oral suspension
Oral tablet
Oral tablet, chewable

Oral tablet

Oral tablet, disintegrating

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

4 hours

7 hours

11 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

Prior To 30 Weeks Gestation

Category D Positive evidence of risk

Starting At 30 Weeks Gestation

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Summary unavailable.

See the full pregnancy warnings document.

Drug Interactions

A total of 415 drugs are known to interact with Ibuprofen:

99 major drug interactions (440 brand and generic names)
301 moderate drug interactions (1158 brand and generic names)
15 minor drug interactions (78 brand and generic names)

A total of 248 drugs are known to interact with Ubrelvy:

38 major drug interactions (96 brand and generic names)
209 moderate drug interactions (600 brand and generic names)
1 minor drug interactions (2 brand and generic names)

A total of 169 drugs are known to interact with Nurtec ODT:

57 major drug interactions (174 brand and generic names)
111 moderate drug interactions (315 brand and generic names)
1 minor drug interactions (2 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Ask your doctor before using ibuprofen together with alcohol. Do not drink alcohol while taking... View more

Grapefruit and grapefruit juice can increase the blood levels of ubrogepant. This may increase... View more

If you are receiving therapy with rimegepant you may want to avoid the regular consumption of large... View more

Disease Interactions

First Approval Date

September 19, 1974

December 23, 2019

February 27, 2020

WADA Class View classifications

N/A

More Information

Patient Resources

Ubrelvy uses

Nurtec ODT uses

Professional Resources

Prescribing information

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Ibuprofen Alternatives Compared

See also:

Ubrelvy

Nurtec ODT

Qulipta

Paracetamol

Tylenol

Cymbalta

Lyrica

Celebrex

Humira

Benadryl

Further information

Ibuprofen Alternatives Compared

See also:

Further information

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