Diazepam Alternatives Compared

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Diazepam	Xanax (alprazolam)	Clonazepam	Enter another drug to compare

Diazepam

Xanax (alprazolam)

Clonazepam

Prescription only

Diazepam may be used occasionally to relieve anxiety and prolonged seizures; however, it is addictive and withdrawal symptoms can be severe. Prescribed for Anxiety, Back Pain, Hyperekplexia... View more

Prescription only

Xanax may be used for the treatment of anxiety or panic disorder; however, it is addictive, and withdrawal symptoms can be severe. Can interact with several drugs including those that cause... View more

Prescription only

Clonazepam may reduce seizure frequency in specific seizure disorders and can be used short-term for panic disorder, to relieve anxiety, or to sedate. When used long-term it can cause dependence and... View more

More about Diazepam

More about Xanax (alprazolam)

More about Clonazepam

Ratings & Reviews

Diazepam has an average rating of 8.4 out of 10 from a total of 888 ratings on Drugs.com. 81% of reviewers reported a positive effect, while 9% reported a negative effect.

Xanax has an average rating of 8.6 out of 10 from a total of 919 ratings on Drugs.com. 82% of reviewers reported a positive effect, while 8% reported a negative effect.

Clonazepam has an average rating of 8.2 out of 10 from a total of 2180 ratings on Drugs.com. 78% of reviewers reported a positive effect, while 12% reported a negative effect.

View all 888 reviews

View all 919 reviews

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Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

Anxiety (8.0%)
Drowsiness (5.5%)
Withdrawal (4.4%)
Addiction (3.0%)
Muscle spasms (3.0%)
Panic attacks (2.8%)
Tremors (2.6%)

View all Diazepam side effects

Addiction (5.7%)
Anxiety (5.5%)
Withdrawal (5.2%)
Drowsiness (4.6%)
Panic attacks (4.5%)
Insomnia (2.8%)
Tiredness (2.4%)

View all Xanax side effects

Anxiety (7.1%)
Drowsiness (6.7%)
Withdrawal (6.5%)
Insomnia (4.7%)
Tiredness (3.2%)
Depression (3.2%)
Panic attacks (3.1%)

View all Clonazepam side effects

Drug Class

Benzodiazepines

Generic Availability

Lower cost generic

Lower cost generic approved

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	4 tablet
Strength	5 mg
Per unit^*	$2.56
Cost^*	$10.22

View all Diazepam prices

Quantity	100 tablet
Strength	0.25 mg
Per unit^*	$6.09
Cost^*	$609.00

View all Xanax prices

Quantity	10 tablet
Strength	0.5 mg
Per unit^*	$1.04 - $1.22
Cost^*	$10.36 - $12.19

View all Clonazepam prices

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Dosage Forms

Injectable solution
Oral concentrate
Oral solution
Oral tablet
Rectal kit

Oral tablet

Oral tablet
Oral tablet, disintegrating

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

70 hours

20 hours

40 hours

CSA Schedule ¹ View glossary of CSA terms

Some potential for abuse

Has a low potential for abuse relative to those in schedule 3. It has a currently accepted medical use in treatment in the United States. Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.

Some potential for abuse

Pregnancy Category

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Category D Positive evidence of risk

See the full pregnancy warnings document.

Drug Interactions

A total of 525 drugs are known to interact with Diazepam:

32 major drug interactions (166 brand and generic names)
447 moderate drug interactions (1660 brand and generic names)
46 minor drug interactions (386 brand and generic names)

A total of 562 drugs are known to interact with Xanax:

55 major drug interactions (214 brand and generic names)
467 moderate drug interactions (1725 brand and generic names)
40 minor drug interactions (331 brand and generic names)

A total of 532 drugs are known to interact with Clonazepam:

30 major drug interactions (155 brand and generic names)
469 moderate drug interactions (1736 brand and generic names)
33 minor drug interactions (210 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Grapefruit and grapefruit juice may interact with diazePAM and lead to potentially dangerous side... View more

Grapefruit and grapefruit juice may interact with ALPRAZolam and lead to potentially dangerous side... View more

Using clonazePAM together with alcohol can increase nervous system side effects such as dizziness... View more

Disease Interactions

First Approval Date

November 15, 1963

N/A

June 04, 1975

WADA Class View classifications

N/A

More Information

Patient Resources

Diazepam uses

Xanax uses

Clonazepam uses

Professional Resources

Prescribing information

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Diazepam Alternatives Compared

See also:

Paracetamol

Tylenol

Ozempic

Lexapro

Xanax

Cymbalta

Lamictal

Lyrica

Depakote

Ativan

Further information

Diazepam Alternatives Compared

See also:

Further information

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